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Cat. No.	Product Name	Target	Signaling Pathways
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T0219	Valdecoxib 伐地考昔,代他考昔,SC 65872	COX	Immunology/Inflammation; Neuroscience
	Valdecoxib (SC 65872) 是可口服的高选择性 COX-2抑制剂，对 COX-2 和 COX-1 的 IC50值分别为 5 nM 和 140 μM，可用于治疗骨关节炎、类风湿性关节炎以及痛经和经期症状。
T30937	Cimicoxib UR-8880,UR8880,trade name: Cimalgex	COX	Immunology/Inflammation; Neuroscience
	Cimicoxib (UR8880) 是一种有效的、选择性的 COX-2 抑制剂，具有抗炎和镇痛活性。
T21294	Polmacoxib CG-100649,帕马考昔,CG100649,CG 100649	COX; Carbonic Anhydrase	Immunology/Inflammation; Metabolism; Neuroscience
	Polmacoxib (CG 100649) 是一流的 NSAID 候选药物，是碳酸酐酶 (CA) 和 COX-2 的双重抑制剂。它在小鼠模型中抑制大肠腺瘤和肿瘤生长。
T11005	Desmethyl Celecoxib	COX	Immunology/Inflammation; Neuroscience
	Desmethyl Celecoxib 是一种选择性的环氧化酶 2 (COX-2) 抑制剂，IC50为 32 nM，具有抗炎活性。
T0484	Deracoxib SC 46,SC 046,地拉考昔,SC 59046	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。它也是选择性 cyclooxygenase-2 抑制剂，IC50 值：70 至 150 μM，抑制 3 种骨肉瘤细胞系。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T26109	Robenacoxib Onsior	COX	Immunology/Inflammation; Neuroscience
	Robenacoxib (Onsior) 是一种对环氧化酶-2 有很强的选择性的非甾体化合物，具有抗炎活性。
T7670	Mavacoxib	COX	Immunology/Inflammation; Neuroscience
	Mavacoxib 是口服长效环氧合酶 2 选择性抑制剂，是长效的非甾体类抗炎药，用于犬退化性关节病相关的炎疼及痛症的研究。
T1780	Parecoxib SC 69124,帕瑞昔布,Vorth-P,Valus-P	COX	Immunology/Inflammation; Neuroscience
	Parecoxib (SC 69124) 是一种有效的选择性 COX-2 抑制剂，是 Valdecoxib 的前药。
T15571	Imrecoxib BAP-909,艾瑞昔布	COX	Immunology/Inflammation; Neuroscience
	Imrecoxib (BAP-909) 是 COX1和 COX2的抑制剂，IC50值为 115 和 18 nM，具有抗炎作用。
T6574	Lumiracoxib Prexige,罗美昔布,COX-189	COX	Immunology/Inflammation; Neuroscience
	Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂，Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂，具有抗炎和解热活性，可用于骨关节炎和骨癌研究。
T0466	Celecoxib 塞来西布,塞来昔布,SC 58635	COX	Immunology/Inflammation; Neuroscience
	Celecoxib (SC 58635) 是一种非甾体抗炎药，是选择性的COX-2抑制剂，IC50为 40 nM。
T7596	Firocoxib 非罗考昔,ML 1785713	COX	Immunology/Inflammation; Neuroscience
	Firocoxib (ML 1785713) 是一种可口服的 COX-2选择性抑制剂，IC50为 0.13 μM。它具有抗炎作用，对 COX-2的选择性比对 COX-1 的选择性高 58 倍，IC50为 7.5 μM。
T1574	Etoricoxib Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔	COX	Immunology/Inflammation; Neuroscience
	Etoricoxib (MK-663) 是一种合成的非甾体抗炎药 (NSAID)，具有解热、镇痛和潜在的抗肿瘤特性。它是可口服的选择性 COX-2抑制剂，对人全血 COX-2 和 COX-1 的 IC50值分别为 1.1 和 116 μM。
T1185	Rofecoxib MK 966,罗非昔布,罗非考昔,MK-0966	COX	Immunology/Inflammation; Neuroscience
	Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂，具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中，对人 COX-2 的 IC50值分别为 26 和 18 nM。
T24940	Vitacoxib
	Vitacoxib is a selective inhibitor of COX-2. It is used as a novel nonsteroidal anti-inflammatory agent.
T1574L	Etoricoxib HCl L-791456 monohydrochloride salt,L791456 hydrochloride,L-791456 hydrochloride,L 791456 hydrochloride,Etoricoxib hydrochloride
	Etoricoxib HCl is a synthetic, nonsteroidal anti-inflammatory drug. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2, resulting in inhibition of the conversion of arachidonic acid into prostaglandins.
T70018	Apricoxib
	Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related...
T27233	Enflicoxib E 6087,E6087,E-6087
	E-6087 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain.
T37251	Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
	Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.
T68571	Lefucoxib
	Lefucoxib is a cyclooxygenase-2 (COX-2) inhibitor.
T1780L	Parecoxib sodium SC 69124A,SC-69124A,帕瑞昔布钠,SC69124A,Dynastat
	Parecoxib is a cyclooxygenase-2 inhibitor used for the short-term treatment of postoperative pain in adults. Parecoxib is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib and r
T15630	Tilmacoxib RWJ57504,JTP19605,替马考昔,JTE522	COX	Immunology/Inflammation; Neuroscience
	Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).
T36187	Celecoxib Carboxylic Acid
	Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9. 1.Liu, H., Huang, X., Shen, J., et al.Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: Molecular docking and 3D QSAR analysesJ. Med. Chem.45(22)4816-4827(2002) 2.Kim, S.-H., Kim, D.-H., Byeon, J.-Y., et al.Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecox...
T28541	Ritipenem Acoxil Ritipenem acetoxymethyl ester,RIPM-AC
	Ritipenem Acoxil is an antibiotics.
T70154	1-Hydroxyvaldecoxib
	1-Hydroxyvaldecoxib is a COX-2 inhibitor.
T83327	4'-Aarboxylic acid imrecoxib
	4'-羧基酸imrecoxib是Imrecoxib的代谢产物，后者为选择性COX-II抑制剂。
T11246	Etoricoxib-d4 MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4	Others	Others
	Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.Etoricoxib D4 is a deuterium labeled Etoricoxib.
T39627	Ocarocoxib
	Ocarocoxib, a potent COX- 2 (cyclooxygenase- 2) inhibitor, is a non-steroidal anti-inflammatory for veterinary use.

化合物

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Cat.No: T0219

Synonym: 伐地考昔,代他考昔,SC 65872

Target: COX

Cat.No: T30937

Synonym: UR-8880,UR8880,trade name: Cimalgex

Target: COX

Cat.No: T21294

Synonym: CG-100649,帕马考昔,CG100649,CG 100649

Target: COX, Carbonic Anhydrase

Desmethyl Celecoxib

Cat.No: T11005

Target: COX

Cat.No: T0484

Synonym: SC 46,SC 046,地拉考昔,SC 59046

Target: Apoptosis, COX

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T26109

Synonym: Onsior

Target: COX

Cat.No: T7670

Target: COX

Cat.No: T1780

Synonym: SC 69124,帕瑞昔布,Vorth-P,Valus-P

Target: COX

Cat.No: T15571

Synonym: BAP-909,艾瑞昔布

Target: COX

Cat.No: T6574

Synonym: Prexige,罗美昔布,COX-189

Target: COX

Cat.No: T0466

Synonym: 塞来西布,塞来昔布,SC 58635

Target: COX

Cat.No: T7596

Synonym: 非罗考昔,ML 1785713

Target: COX

Cat.No: T1574

Synonym: Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔

Target: COX

Cat.No: T1185

Synonym: MK 966,罗非昔布,罗非考昔,MK-0966

Target: COX

Cat.No: T24940

Cat.No: T1574L

Synonym: L-791456 monohydrochloride salt,L791456 hydrochloride,L-791456 hydrochloride,L 791456 hydrochloride,Etoricoxib hydrochloride

Cat.No: T70018

Cat.No: T27233

Synonym: E 6087,E6087,E-6087

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide

Cat.No: T37251

Cat.No: T68571

Parecoxib sodium

Cat.No: T1780L

Synonym: SC 69124A,SC-69124A,帕瑞昔布钠,SC69124A,Dynastat

Cat.No: T15630

Synonym: RWJ57504,JTP19605,替马考昔,JTE522

Target: COX

Celecoxib Carboxylic Acid

Cat.No: T36187

Ritipenem Acoxil

Cat.No: T28541

Synonym: Ritipenem acetoxymethyl ester,RIPM-AC

1-Hydroxyvaldecoxib

Cat.No: T70154

4'-Aarboxylic acid imrecoxib

Cat.No: T83327

Cat.No: T11246

Synonym: MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4

Target: Others

Cat.No: T39627

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