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Cat. No. | Product Name | Target | Signaling Pathways |
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T5858 |
Sertindole
Lu 23-174,舍吲哚 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Sertindole (Lu 23-174) 是一种非典型抗精神病药,可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合,Kd 值分别为 2.7、20、0.14 和 6 nM。 | |||
T60659 |
Cdc7-IN-12
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Cdc7-IN-12 (compound 1) 是 CDC7的有效抑制剂(IC50为 <1 nM),在癌症研究中具有潜力。Cdc7-IN-12 在人结肠癌细胞COLO205 中表现出抗增殖活性,IC50为 100-1000 nM。 | |||
T78763 |
ABCB1-IN-1
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ABCB1-IN-1 (compound 3) 为高效ABCB1抑制剂,可诱导细胞凋亡。含1-苯甲基咪唑基团,其对Colo205与Colo320细胞系展现出的IC50分别为1.26 μM与2.21 μM。 | |||
T79112 |
CDK4/6-IN-17
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CDK | Cell Cycle/Checkpoint |
CDK4/6-IN-17(compound 12)为具有口服活性的CDK4/6抑制剂,在BE(2)细胞的IC50为10-100 nM。CDK4/6-IN-17在COLO205异种移植模型中有效抑制肿瘤生长。 | |||
T62939 | SHR2415 | ||
SHR2415 是一种选择性的、高效的、口服具有活力的 ERK1/2 抑制剂。SHR2415 能够抑制 ERK1 (IC50: 2.8 nM) 和 ERK2 (IC50: 5.9 nM)。SHR2415 在 Colo205 细胞中表现出高效力 (IC50: 44.6 nM)。SHR2415 能够用于癌症的研究。 | |||
T79592 |
COX-1/2-IN-4
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COX | Immunology/Inflammation; Neuroscience |
COX-1/2-IN-4 为COX-1与COX-2酶的抑制剂,其IC50值分别为0.239 μM与0.191 μM。此化合物在对COLO205与B16F1癌细胞系表现出中等程度的抗癌活性,对应IC50值分别为30.79 μM与74.15 μM。 | |||
T61436 |
Cdc7-IN-18
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Cdc7-IN-18 (compound 1-2) is a highly effective inhibitor of the CDC7 enzyme. It has an IC 50 value of 1.29 nM for the Cdc7/DBF4 enzyme. In addition, this compound exhibits strong antiproliferative activities, with an IC 50 value of 53.62 nM in COLO205 cells [1]. | |||
T70424 | EBI-907 | ||
EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases i... | |||
T69221 |
BMS-554417
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BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosph... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2S0357 |
6-Hydroxycoumarin
6-hydroxychromen-2-one,6-羟基香豆素 |
Others; Carbonic Anhydrase | Metabolism; Others |
6-Hydroxycoumarin (6-hydroxychromen-2-one) 是一种香豆素。其中香豆素具有抗炎,支气管扩张,解热,血管扩张,抗氧化,抗菌,抗真菌,抑菌和抗肿瘤作用。 |