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Cat. No.	Product Name	Target	Signaling Pathways
T10741	CDK9-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T118066	CDK9 inhibitor HH1 8019-9719	CDK	Cell Cycle/Checkpoint
	CDK9 inhibitor HH1 (8019-9719) 是人类 CDK2-cyclin A2复合物的抑制剂，IC50为2 μM。
T63851	CDK9/10/GSK3β-IN-1
	CDK9/10/GSK3β-IN-1 是一种激酶抑制剂 (Flavopiridol 类似物)，能有效抑制 HsGSK3β、HsCDK9/CyclinT、HsCDK5/p25 和 HsCDK2/CyclinA，其 IC50 值分别为 59 nM、64 nM、1.093 μM 和 1.725 μM。CDK9/10/GSK3β-IN-1 表现出相当或高于 Flavopiridol 的抗癌细胞活性，在体外对多达七种癌细胞系表现出高抗增殖活性。
T39997	PROTAC CDK9 ligand-1 PROTAC CDK9 ligand-1
	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T62746	EGFR/HER2/CDK9-IN-1
	EGFR/HER2/CDK9-IN-1 (Compound 4) 是一种有效的 EGFR/HER2/CDK9 抑制剂，他们的 IC50 值分别为 90.17、131.39 和 67.04 nM。EGFR/HER2/CDK9-IN-1 表现出明显的抗肿瘤作用。
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T82758	CDK9-Cyclin T1 PPI-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) 是CDK9-Cyclin T1蛋白-蛋白相互作用的选择性抑制剂。该化合物能够有效抑制TNBC MDA-MB-231细胞系的细胞增殖(IC50: 0.044 μM)，诱导细胞凋亡，同时降低CDK9的转录活性并减少RNA Pol II CTD ser2的磷酸化，有效地抑制了4T1移植瘤模型小鼠中肿瘤的生长。
T5438	PROTAC CDK9 Degrader-1	CDK	Cell Cycle/Checkpoint
	PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。
T70400	CDK9/CycT1-IN-93
	CDK9/CycT1-IN-93 is a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.
T79904	PROTAC CDK9/CycT1 Degrader-2	CDK	Cell Cycle/Checkpoint
	PROTACCDK9/CycT1 Degrader-2 对CDK9表现出较高的抑制效能，具有一个IC50值为45 nM。
T74707	PROTAC FLT3/CDK9 degrader-1
	PROTACFLT3/CDK9 degrader-1 是一种有效的FLT3和CDK9双PROTAC 降解剂。PROTACFLT3/CDK9 degrader-1 诱导细胞凋亡 (Apoptosis) 并有效降解靶蛋白FLT3和 CDK9。PROTACFLT3/CDK9 degrader-1具有研究 FLT3-ITD 突变型 AML 的潜力。
T9632	CDK9-IN-30	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	CDK9-IN-30 是 Tat 肽衍生物之一，可抑制 HIV-1 长末端重复激活转录。
T23840	BUR1 BMP upregulator-1,1-{1-苯基-1H-吡唑并[3,4-D]嘧啶-4-基}哌啶,BMP upregulator 1,BUR 1,BUR-1	CDK	Cell Cycle/Checkpoint
	BUR1 是一种酿酒酵母细胞周期蛋白依赖性激酶 (CDK)，与在转录延伸中起作用的哺乳动物 Cdk9 同源。
T10096L	Voruciclib	CDK	Cell Cycle/Checkpoint
	Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂，Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。
T79631	CDK9-IN-26	CDK	Cell Cycle/Checkpoint
	CDK9-IN-26 (化合物1d) 为CDK9抑制剂，具有0.18 µM的IC50值。
T10743	CDK9-IN-11	CDK	Cell Cycle/Checkpoint
	CDK9-IN-11 是一种有效的CDK9抑制剂，可作为 PROTAC CDK9 Degrader-1 的配体。
T82757	CDK9-IN-29	CDK	Cell Cycle/Checkpoint
	CDK9-IN-29，一有效CDK9抑制剂(IC50=3.20 nM)，激酶选择性佳，能抑制细胞增殖及诱导细胞凋亡。
T79367	CDK9-IN-27	CDK	Cell Cycle/Checkpoint
	CDK9-IN-27（Compound 6a）是一款针对CDK9的抑制剂，其IC50s为0.424 μM。该化合物可诱导细胞凋亡（apoptosis）及S期细胞周期停滞，并对HepG2、HCT-116及MCF-7细胞系展现出细胞毒性，其IC50s介于10.31至40.34 μM之间。CDK9-IN-27主要应用于癌症相关研究领域。
T14915	CDK12-IN-E9	CDK	Cell Cycle/Checkpoint
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).
T79704	CDK9-IN-28	CDK	Cell Cycle/Checkpoint
	CDK9-IN-28（化合物10）是一种高效CDK9抑制剂，可用作PROTAC合成中的靶蛋白配体，并在实体瘤中展现出显著的抗增殖能力。
T79037	CDK9-IN-23	CDK	Cell Cycle/Checkpoint
	CDK9-IN-23 (Example 4)作为一种CDK9抑制剂，其半抑制浓度（IC50）小于20纳摩尔（nM）。
T17728	PROTAC CDK9 degrader-2	Others	Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
T78928	PROTAC CDK9 degrader-8	PROTACs	PROTAC
	PROTACCDK9degrader-8 (化合物21) 是具有0.01 μM IC50值的高效PROTAC CDK9降解剂，适用于癌症研究领域。
T79354	CDK9-IN-24	CDK	Cell Cycle/Checkpoint
	CDK9-IN-24（化合物21a）为高选择性CDK9抑制剂，显著抑止肿瘤生长。该化合物有效抑制细胞增殖，通过降调Mcl-1及c-Myc诱导细胞凋亡，适用于急性髓系白血病研究。
T10739	CDK8/19-IN-1	CDK	Cell Cycle/Checkpoint
	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T71287	CDKI-83
	CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be devel...
T40353	CDK7/9-IN-1 CDK7/9-IN-1
	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su...
T79630	CDK9-IN-25	Virus Protease	Microbiology/Virology
	CDK9-IN-25（化合物4a）为咪唑并吡嗪类 CDK9 抑制剂，其 IC50 值为0.24 μM。该化合物对 COVID-19 主要蛋白酶展现出良好的亲和力，并对人类冠状病毒 229E 表现出抗病毒活性，其 IC50 值达到 63.28 μM。
T40047	CDK6/9-IN-1 CDK6/9-IN-1
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
T60477	Haspin-IN-1
	Haspin-IN-1 (compound 2a) 是一种haspin（单倍体生殖细胞特异性核蛋白激酶）抑制剂，IC50值为 119 nM。Haspin-IN-1 还抑制CLK1、DYRK1A 和 CDK9，IC50分别为 221 nM 、916.3 nM 和406.8 nM。Haspin-IN-1具有开发新型抗癌药物的潜力[1]。
T78837	CP-07	CDK	Cell Cycle/Checkpoint
	CP-07为高效的PROTAC CDK9选择性降解剂（DC50：43 nM），能显著抑制22RV1细胞增殖（IC50：62 nM）及集落形成，其作用机制为通过下调Mcl-1与c-Myc。此外，CP-07有效抑制22RV1异种移植肿瘤的生长，有望成为研究前列腺癌的重要化合物。
T79014	QR-6401	CDK	Cell Cycle/Checkpoint
	QR-6401是一种口服、选择性的大环CDK2抑制剂，其IC50分别针对CDK2/E1、CDK9/T1、CDK1/A2、CDK6/D3和CDK4/D1为0.37、10、22、34及45nM。在OVCAR3卵巢癌异种移植模型中，QR-6401表现出显著的抗肿瘤活性，显示出其作为癌症研究工具的潜能。
T78906	CDK/HDAC-IN-3	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CDK/HDAC-IN-3 是一种口服活性的 HDAC/CDK 双重抑制剂，对 CDK9、CDK12、CDK13 及 HDAC1、HDAC2、HDAC3 表现出有效且选择性的抑制，IC50 值分别为 98.32 nM、98.85 nM、100 nM、62.12 nM、93.28 nM 和 82.87 nM。该化合物主要用于急性髓性白血病 (AML) 的相关研究。
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...
T79287	SB-1295	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	SB-1295是一种口服活性CDK9/T1抑制剂，其IC50为0.17 μM。在HCT 116和MIA PaCa-2细胞中表现出抗增殖效应，并能诱导MIA PaCa-2细胞死亡，机制包括ROS生成增加、线粒体膜电位下降及细胞凋亡启动。SB-1295具备作为癌症研究工具的潜力。

化合物

Cat.No: T10741

Target: CDK

CDK9 inhibitor HH1

Cat.No: T118066

Synonym: 8019-9719

Target: CDK

CDK9/10/GSK3β-IN-1

Cat.No: T63851

PROTAC CDK9 ligand-1

Cat.No: T39997

Synonym: PROTAC CDK9 ligand-1

EGFR/HER2/CDK9-IN-1

Cat.No: T62746

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

CDK9-Cyclin T1 PPI-IN-1

Cat.No: T82758

Target: CDK

PROTAC CDK9 Degrader-1

Cat.No: T5438

Target: CDK

CDK9/CycT1-IN-93

Cat.No: T70400

PROTAC CDK9/CycT1 Degrader-2

Cat.No: T79904

Target: CDK

PROTAC FLT3/CDK9 degrader-1

Cat.No: T74707

Cat.No: T9632

Target: HIV Protease

Cat.No: T23840

Synonym: BMP upregulator-1,1-{1-苯基-1H-吡唑并[3,4-D]嘧啶-4-基}哌啶,BMP upregulator 1,BUR 1,BUR-1

Target: CDK

Cat.No: T10096L

Target: CDK

Cat.No: T79631

Target: CDK

Cat.No: T10743

Target: CDK

Cat.No: T82757

Target: CDK

Cat.No: T79367

Target: CDK

Cat.No: T14915

Target: CDK

Cat.No: T79704

Target: CDK

Cat.No: T79037

Target: CDK

PROTAC CDK9 degrader-2

Cat.No: T17728

Target: Others

PROTAC CDK9 degrader-8

Cat.No: T78928

Target: PROTACs

Cat.No: T79354

Target: CDK

Cat.No: T10739

Target: CDK

Cat.No: T36743

Cat.No: T71287

Cat.No: T40353

Synonym: CDK7/9-IN-1

Cat.No: T79630

Target: Virus Protease

Cat.No: T40047

Synonym: CDK6/9-IN-1

Cat.No: T60477

Cat.No: T78837

Target: CDK

Cat.No: T79014

Target: CDK

CDK/HDAC-IN-3

Cat.No: T78906

Target: HDAC

Cat.No: T70988

Cat.No: T79287

Target: Reactive Oxygen Species

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