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Cat. No. | Product Name | Target | Signaling Pathways |
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T63188 |
Apoptotic agent-2
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Apoptotic agent-2 能够使 Bcl-2 下调,并上调 Bax 和 caspase-3 诱导细胞凋亡 (apoptosis),表现出抗增殖作用,能够用于研究癌症。 | |||
T15180 |
Duocarmycin A
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Caspase | Apoptosis; Proteases/Proteasome |
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes. | |||
T62814 |
Antitumor agent-77
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Antitumor agent-77 对癌细胞的生长和迁移具有抑制作用,具有抗癌作用。Antitumor agent-77 能够抑制 GPx-4 和提高 COX2 引发铁下垂。Antitumor agent-77 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3),阻碍肿瘤细胞上皮间质转化 (EMT) 过程。 | |||
T76371 |
Tumor targeted pro-apoptotic peptide
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Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) 为抗肿瘤肽,具有破坏线粒体膜和促进细胞凋亡功能,展现小鼠的抗癌活性。 | |||
T63530 |
Apoptotic agent-3
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Apoptotic agent-3 利用潜在的线粒体介导的 Bcl-2/Bax 通路和激活 caspase-3 途径促进凋亡,表现出抗增殖作用,能够用于研究癌症。 | |||
T63768 |
Antitumor agent-78
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Antitumor agent-78 能够抑制 GPx-4 和升高 COX2 ,进而导致铁下垂 (ferroptosis)。Antitumor agent-78 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3),抑制肿瘤细胞上皮间质转化 (EMT) 过程。Antitumor agent-78 表现出抗肿瘤效果,并能够抑制癌细胞的生长和迁移。 | |||
T4620 |
Siramesine
西拉美新,Lu 28-179 |
Sigma receptor | GPCR/G Protein |
Siramesine (Lu 28-179) 是sigma-2受体激动剂,通过线粒体的不稳定溶酶体触发细胞死亡,有强大的抗癌活性。它对 sigma-2 受体具有亚纳摩尔亲和力,IC50为 0.12 nM。它对 sigma-2 受体的选择性是 sigma-1 受体的 140倍,IC50为 17 nM。 | |||
T74393 | Antitumor agent-36 | ||
Antitumor agent-36 具有有效的抗增殖和抗转移活性,能诱导严重的 DNA 损伤,并通过增加 γ-H2AX 和 p53 的表达促进肿瘤细胞通过 Bcl-2/Bax/caspase3 线粒体凋亡通路的 (apoptosis)。此外,Antitumor agent-36 还能通过抑制 PD-L1 的表达显著增加肿瘤组织中 CD3+ 和 CD8+ T 浸润细胞,从而改善免疫反应。 | |||
T71110 |
Nanatinostat TFA
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Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7028 |
Licochalcone C
LICOCHALCONEC,甘草查尔酮C |
Phosphatase; Antioxidant; Glucosidase | Metabolism; oxidation-reduction |
Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶,其对 α-葡萄糖苷酶的 IC50 <100 nM,对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。 | |||
T4S1637 |
gamma-Mangostin
Normangostin,γ-倒捻子素 |
Others; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
gamma-Mangostin (Normangostin) 是从药用植物山竹的果壳中提纯的一种天然产物,是一种竞争性5-HT2A 受体拮抗剂。它是运甲状腺素蛋白原纤维化抑制剂,与甲状腺素结合位点结合并稳定了 TTR 四聚体,具有抗高血压、预防结肠癌等作用。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T14317 |
ar-Turmerone
(+)-ar-Turmerone |
Others | Others |
ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation. | |||
TN6059 |
Demethoxyfumitremorgin C
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Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex |