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4

抑制剂 & 化合物

10

天然产物

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Cat. No. Product Name Target Signaling Pathways
T61312 Antioxidant agent-3

Antioxidant agent-3 (Compound 14q) 是一种抗氧化剂,具有有效的DPPH 自由基清除活性和ABTS+清除活性,IC50分别为 26.58 和 30.31 μM。Antioxidant agent-3 作用于 H2O2处理的 HepG2 细胞,可增加活性氧 (ROS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH),并减少乳酸脱氢酶(LDH)。
T62697 BuChE-IN-3

BuChE-IN-3 (Compound C4) 是一种 BuChE 的有效抑制剂 (IC50: 8.3 nM)。BuChE-IN-3 具有温和的抗氧化能力、无毒、亲脂性和神经保护效果。
T36516 RC574

RC574

RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T36515 RC363

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT2...

化合物

Antioxidant agent-3
Cat.No: T61312
Synonym:
Target:
BuChE-IN-3
Cat.No: T62697
Synonym:
Target:
RC574
Cat.No: T36516
Synonym: RC574
Target:
RC363
Cat.No: T36515
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T6S0078 Oxypeucedanin hydrate

Prangolarin Hydrate,水合氧化前胡素

Antioxidant oxidation-reduction
Oxypeucedanin hydrate (Prangolarin Hydrate) 是一种分离自D. anethifolia 中的天然香豆素化合物,存在于几种植物中,具有抗感染和抗真菌活性。
T0562 Protocatechuic acid

3, 4-Dihydroxybenzoic acid,3,4-二羟基苯甲酸,Protocatechuate,原儿茶酸,3,4-Dihydroxybenzoic acid

Others Others
Protocatechuic acid (3, 4-Dihydroxybenzoic acid) 是天然的多酚类物质,具有神经保护活性。
TCS1704 Artemitin

艾黄素,Artemetin,Artemisetin,Erianthin

Antioxidant oxidation-reduction
Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮,具有抗氧化、抗炎、抗病毒活性。
T6S1684 8-Gingerol

Antioxidant; Antibacterial; TRP/TRPV Channel Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
8-Gingerol 分离自姜的根状茎,是口服有效的 TRPV1激活剂,EC50值为5.0 µM。8-Gingerol 抑制 COX-2,还能抑制体外 H. pylori 的生长。
T6S0232 Eriodictyol

圣草酚,Huazhongilexone

Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology
Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物,具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 18 nM。它可诱导Nrf2信号通路。
T4S0969 Obtusifolin

决明蒽醌,决明蒽醌;美决明子素

Antioxidant; NF-κB NF-κB; oxidation-reduction
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T2S1865 Octyl gallate

Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T3794 Pentagalloylglucose

Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Influenza Virus Microbiology/Virology
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T83031 Antioxidant agent-10

Antioxidant agent-10 (Compound 3),其DPPH清除活性属于中等,具有EC50值为33.2 μg/mL。
TN2045 Pelargonidin-3-O-glucoside chloride

Others; Estrogen/progestogen Receptor Endocrinology/Hormones; Others
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrogenic, and angiotensin-converting enzyme inhibitory activities.

天然产物

Oxypeucedanin hydrate
Cat.No: T6S0078
Synonym: Prangolarin Hydrate,水合氧化前胡素
Target: Antioxidant
Protocatechuic acid
Cat.No: T0562
Synonym: 3, 4-Dihydroxybenzoic acid,3,4-二羟基苯甲酸,Protocatechuate,原儿茶酸,3,4-Dihydroxybenzoic acid
Target: Others
Artemitin
Cat.No: TCS1704
Synonym: 艾黄素,Artemetin,Artemisetin,Erianthin
Target: Antioxidant
8-Gingerol
Cat.No: T6S1684
Synonym:
Target: Antioxidant, Antibacterial, TRP/TRPV Channel
Eriodictyol
Cat.No: T6S0232
Synonym: 圣草酚,Huazhongilexone
Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite
Obtusifolin
Cat.No: T4S0969
Synonym: 决明蒽醌,决明蒽醌;美决明子素
Target: Antioxidant, NF-κB
Octyl gallate
Cat.No: T2S1865
Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯
Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV
Pentagalloylglucose
Cat.No: T3794
Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖
Target: Influenza Virus
Antioxidant agent-10
Cat.No: T83031
Synonym:
Target:
Pelargonidin-3-O-glucoside chloride
Cat.No: TN2045
Synonym:
Target: Others, Estrogen/progestogen Receptor
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