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Search Results for " amyloid β-protein "

78

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1786L	Amyloid β-Protein 10-20 acetate Amyloid β-Protein 10-20 acetate(152286-31-2 free base)	Beta Amyloid	Neuroscience
	Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段，可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点（Lys16-Leu17 键）。它还包含负责与小胶质细胞结合的 HHQK 结构域（残基 13-16）。
TP1229	β-Amyloid (1-15) Amyloid β-Protein (1-15)	Beta Amyloid	Neuroscience
	β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段，可用于研究阿尔茨海默病。
TP1655	β-Amyloid Protein Precursor 770 (135-155) β-Amyloid Protein Precursor 770 135-155
	Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T6483	EHT 1864 EHT 1864 2HCl	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHT 1864 是 Rac 家族 GTPase 抑制剂，对 Rac1、Rac1b、Rac2 和 Rac3的Kd 为 40、50、60 和 250 nM。
TP1228	β-Amyloid (1-16) Amyloid β-Protein (1-16),β-Amyloid 1-16
	β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD).
TP1225	β-Amyloid (22-35) β-Amyloid 22-35,Amyloid β-Protein (22-35)
	β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide.
TP1227	β-Amyloid (12-28) β-amyloid 12-28,Amyloid β-Protein (12-28)
	Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.
TP1786	β-Amyloid (10-20) Amyloid β-Protein 10-20
	Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) re
TP1226	β-Amyloid (1-28) Amyloid β-Protein (1-28),β-Amyloid 1-28
	β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.
TP1231	β-Amyloid (29-40) Amyloid beta-protein(29-40),β-Amyloid 29-40
	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th
TP2171	β-amyloid (12-28) (TFA) (107015-83-8 free base) Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA)	Others	Others
	β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer’s disease research.
T80037	5-FAM-β-Amyloid (1-28) 5-FAM-Amyloid β-protein (1-28)
	5-FAM-β-Amyloid (1-28) 为β-Amyloid (1-28) 分子的荧光标记形式。
T32106	Human beta-amyloid protein 42 (1-7) Vanutide
	Human beta-amyloid protein 42 (1-7) is a bioactive chemical.
T83123	Amyloid β-Protein (3-42)
	Amyloid β-Protein (3-42) 为Pyr肽前体, 其焦谷氨酸修饰的形式 Aβ (pEAβ) (3-42) 构成阿尔茨海默病淀粉样斑块的关键。pEAβ (3-42) 能促进 Aβ(1-42) 聚集，并且 Aβ(1-42) 显著延缓pEAβ(3-42) 的初级及次级成核过程。
T76401	Amyloid β-Protein (33-42) (TFA)
	Amyloid β-Protein (33-42) TFA，β-淀粉样蛋白残基的33-42段，能够抑制Aβ42诱导的毒性。
T76425	(Glu20)-Amyloid β-Protein (1-42)
	(Glu20)-Amyloid β-Protein (1-42) 是一种具有 Glu20 突变的淀粉样蛋白β (Aβ) 变体，该变体的原纤维化速度较慢。此突变能够减少 Aβ 的聚集倾向，进而阻止缓慢原纤化肽的累积。它是阿尔茨海默病中血管及脑内淀粉样沉积物的关键组成部分。
T38149	β-Amyloid (1-43)(human)
	The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.
T37768	β-Amyloid (1-37) (human)
	β-Amyloid (1-37) (human) 与阿尔茨海默病的精神状态有潜在关联。
T83283	5-TAMRA-Amyloid β-Protein (1-40)
	5-TAMRA-Amyloid β-Protein (1-40)为荧光 (TAMRA) 标记的淀粉样β-蛋白（Amyloid β-Protein）(1-40)片段, 其吸收和发射峰值分别位于Abs/Em=544/572 nm。
T76623	(Gln22)-Amyloid β-Protein (1-42)
	'(Gln22)-Amyloid β-Protein (1-42)'，为β-Amyloid (1-42) 的Dutch突变（E22Q）形式，显示出提升的纤维原性及致病性。
T76625	(Lys22)-Amyloid β-Protein (1-42)
	(Lys22)-Amyloid β-Protein (1-42) 是 WT Amyloid β-Protein (1-42) 肽的突变。
T76424	(Gly22)-Amyloid β-Protein (1-42)
	(Gly22)-Amyloid β-Protein (1-42) 为淀粉样蛋白β-蛋白(Aβ)的一种肽段，主要在阿尔茨海默病患者的血管和脑组织中形成淀粉样沉积。Aβ中Glu22至Gly22的突变显著促进了该蛋白的聚集。
T83539	(Pyr11)-Amyloid β-Protein (11-40)
	(Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) 作为一种肽，主要应用于阿尔茨海默病相关研究。
T76432	(D-Asp1)-Amyloid β-Protein (1-42)
	(D-Asp1)-Amyloid β-Protein (1-42)，一种Aβ肽片段，主要构成阿尔茨海默病血管和实质淀粉样沉积物。
T76588	(Asp37)-Amyloid β-Protein (1-42)
	(Asp37)-Amyloid β-Protein (1-42) 是野生型 Amyloid-beta (1-42) 肽的 G37D 突变体。
T76464	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
	FITC-β-Ala-Amyloid β-Protein (1-42) ammonium 是一种关键于阿尔茨海默病发病机制中的 FITC 标记 Aβ1-42 单体肽。
T76395	(Met(O)35)-Amyloid β-Protein (1-42)
	'(Met(O)35)-Amyloid β-Protein (1-42)，Aβ42的一种氧化形态，位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体，适用于阿尔茨海默病（AD）研究。'
T80695	β-Amyloid precursor protein (96-110), cyclized (human)
	β-Amyloid precursor protein (96-110), cyclized (human) 为一种淀粉样前体蛋白衍生物，特别适用于阿尔茨海默病相关研究。
T76434	Biotinyl-Amyloid β-Protein (1-42) (ammonium)
	Biotinyl-Amyloid β-Protein (1-42) ammonium 是一种生物素化的 Amyloid β-Protein (1-42). Amyloid β-Protein (1-42) ammonium 可用于 Aβ1-42 在大脑中转化为 Aβ1-40 的研究。
T76647	Acetyl-Amyloid β-Protein (1-6) amide
	Acetyl-Amyloid β-Protein (1-6) amide 是一种具有潜在铜(II)结合位点的六肽，主要用于阿尔茨海默病及相关疾病的研究。
T76397	(Nle35)-Amyloid β-Protein (1-42) (ammonium)
	(Nle35)-Amyloid β-Protein (1-42) ammonium 是一种肽。
T76465	Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium)
	Biotinyl-Ahx-Amyloid β-Protein (1-42) ammonium 为N-末端接有生物素的 Amyloid β-Protein (1-42)，主要存在于阿尔茨海默病患者血管与脑组织中的淀粉样沉积物中。
T83541	(Gln22,Asn23)-Amyloid β-Protein (1-40)
	(Gln22,Asn23)-Amyloid β-Protein (1-40) 为特定多肽，主要应用于研究脑淀粉样血管病的相关突变。
T76396	(Met(O2)35)-Amyloid β-Protein (1-42)
	(Met(O2)35)-Amyloid β-Protein (1-42) 是一种多肽。
T76433	Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)
	Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) 为淀粉样β蛋白（Aβ）的一段肽片段, 主要应用于阿尔茨海默病研究中。
T76394	Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)
	Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) 为β淀粉样蛋白36至42氨基酸片段，构成阿尔茨海默病患者大脑淀粉样斑块的核心组分。此多肽链含36-43个氨基酸，而β淀粉样低聚物(Aβos)通过引起神经损伤与认知功能障碍，在阿尔茨海默病发展中扮演重要角色。
T83540	(Gly22)-amyloid beta-protein(1-40)
	(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) 是用于阿尔茨海默病研究的肽。
T7490	ARN2966	Beta Amyloid	Neuroscience
	ARN2966 是高效的，针对 APP 表达的转录后调节剂，能够抑制 APP 的表达从而使 Aβ的量降低。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T61439	DSS30	Beta Amyloid; BACE; CDK	Cell Cycle/Checkpoint; Neuroscience
	DSS30 是一种 P25/CDK5抑制剂。DSS30通过抑制淀粉样前体蛋白裂解酶1 (BACEl) 磷酸化，减少 β-淀粉样蛋白 (Aβ) 的分泌发挥作用。DSS30 可用于预防和治疗阿尔茨海默病等神经退行性疾病。
T14338	Atabecestat JNJ-54861911	BACE	Neuroscience
	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T13253	Umibecestat CNP520	BACE	Neuroscience
	Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂，对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM，可用于阿尔茨海默病的研究。
T26947	Caprospinol SP 233,SP233,SP-233
	Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.
T75958	β-Amyloid (22-35) (TFA)
	β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA是β-淀粉样蛋白22-35残基段，具细胞毒性，能影响无血清培养大鼠海马神经元。在中性缓冲液中，此化合物能形成聚集体与典型淀粉样纤维，模拟β-淀粉样蛋白行为。
TP1719	β-Amyloid (33-40) β-Amyloid 33-40
	β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
TP1586	β-Amyloid (35-42) β-Amyloid 35-42
	β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
T12429	PF-06751979	BACE	Neuroscience
	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...

化合物

Amyloid β-Protein 10-20 acetate

Cat.No: TP1786L

Synonym: Amyloid β-Protein 10-20 acetate(152286-31-2 free base)

Target: Beta Amyloid

β-Amyloid (1-15)

Cat.No: TP1229

Synonym: Amyloid β-Protein (1-15)

Target: Beta Amyloid

β-Amyloid Protein Precursor 770 (135-155)

Cat.No: TP1655

Synonym: β-Amyloid Protein Precursor 770 135-155

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

Cat.No: T6483

Synonym: EHT 1864 2HCl

Target: Rho, Ras

β-Amyloid (1-16)

Cat.No: TP1228

Synonym: Amyloid β-Protein (1-16),β-Amyloid 1-16

β-Amyloid (22-35)

Cat.No: TP1225

Synonym: β-Amyloid 22-35,Amyloid β-Protein (22-35)

β-Amyloid (12-28)

Cat.No: TP1227

Synonym: β-amyloid 12-28,Amyloid β-Protein (12-28)

β-Amyloid (10-20)

Cat.No: TP1786

Synonym: Amyloid β-Protein 10-20

β-Amyloid (1-28)

Cat.No: TP1226

Synonym: Amyloid β-Protein (1-28),β-Amyloid 1-28

β-Amyloid (29-40)

Cat.No: TP1231

Synonym: Amyloid beta-protein(29-40),β-Amyloid 29-40

β-amyloid (12-28) (TFA) (107015-83-8 free base)

Cat.No: TP2171

Synonym: Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA)

Target: Others

5-FAM-β-Amyloid (1-28)

Cat.No: T80037

Synonym: 5-FAM-Amyloid β-protein (1-28)

Human beta-amyloid protein 42 (1-7)

Cat.No: T32106

Synonym: Vanutide

Amyloid β-Protein (3-42)

Cat.No: T83123

Amyloid β-Protein (33-42) (TFA)

Cat.No: T76401

(Glu20)-Amyloid β-Protein (1-42)

Cat.No: T76425

β-Amyloid (1-43)(human)

Cat.No: T38149

β-Amyloid (1-37) (human)

Cat.No: T37768

5-TAMRA-Amyloid β-Protein (1-40)

Cat.No: T83283

(Gln22)-Amyloid β-Protein (1-42)

Cat.No: T76623

(Lys22)-Amyloid β-Protein (1-42)

Cat.No: T76625

(Gly22)-Amyloid β-Protein (1-42)

Cat.No: T76424

(Pyr11)-Amyloid β-Protein (11-40)

Cat.No: T83539

(D-Asp1)-Amyloid β-Protein (1-42)

Cat.No: T76432

(Asp37)-Amyloid β-Protein (1-42)

Cat.No: T76588

FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76464

(Met(O)35)-Amyloid β-Protein (1-42)

Cat.No: T76395

β-Amyloid precursor protein (96-110), cyclized (human)

Cat.No: T80695

Biotinyl-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76434

Acetyl-Amyloid β-Protein (1-6) amide

Cat.No: T76647

(Nle35)-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76397

Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76465

(Gln22,Asn23)-Amyloid β-Protein (1-40)

Cat.No: T83541

(Met(O2)35)-Amyloid β-Protein (1-42)

Cat.No: T76396

Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)

Cat.No: T76433

Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)

Cat.No: T76394

(Gly22)-amyloid beta-protein(1-40)

Cat.No: T83540

Cat.No: T7490

Target: Beta Amyloid

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T61439

Target: Beta Amyloid, BACE, CDK

Cat.No: T14338

Synonym: JNJ-54861911

Target: BACE

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Cat.No: T13253

Synonym: CNP520

Target: BACE

Cat.No: T26947

Synonym: SP 233,SP233,SP-233

β-Amyloid (22-35) (TFA)

Cat.No: T75958

β-Amyloid (33-40)

Cat.No: TP1719

Synonym: β-Amyloid 33-40

β-Amyloid (35-42)

Cat.No: TP1586

Synonym: β-Amyloid 35-42

Cat.No: T12429

Target: BACE

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

Cat. No.	Product Name	Target	Signaling Pathways
T83407	2',3'-Dihydroxy-4',6'-dimethoxychalcone
	2',3'-Dihydroxy-4',6'-dimethoxychalcone 能够抑制β淀粉样蛋白(Aβ42)的纤维化与聚集，并具有口服活性，在大脑中可进行检测。

天然产物

2',3'-Dihydroxy-4',6'-dimethoxychalcone

Cat.No: T83407

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