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Search Results for " alkylation "

13

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11120	Duocarmycin TM	DNA Alkylation; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。
T8897	2-Iodoacetamide 碘乙酰胺,2-碘乙酰胺,Iodoacetamide	Others	Others
	2-Iodoacetamide (Iodoacetamide) 是常用的烷基化剂之一，能够在蛋白质组学样品制备过程中，将半胱氨酸烷基化。
T8330	BIO-013077-01 6-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹噁啉	TGF-beta/Smad	Stem Cells
	BIO-013077-01 是吡唑类TGF-β抑制剂。
T4580	4-Octyl itaconate 4-辛基衣康酸,衣康酸盐	Nrf2	Immunology/Inflammation
	4-Octyl Itaconate 是 Itaconate 衍生物，具有细胞渗透性，Itaconate 是一种抗炎代谢产物。4-Octyl Itaconate 可通过 KEAP1 的烷基化而活化 Nrf2，还可抑制 STING 的磷酸化。
T0923	Busulfan Myleran,Sulphabutin,白消安,Busulphan	Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation	Apoptosis; DNA Damage/DNA Repair
	Busulfan (Busulphan) 是二甲磺酸盐的合成衍生物，具有抗肿瘤和细胞毒特性。是一种烷化剂，对骨髓具有选择性免疫抑制作用。
T1488	Procarbazine hydrochloride NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂，是甲基肼衍生物的盐酸盐，具有抗肿瘤和诱变活性。
T31551	Mipicoledine DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN
	DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer.
T11118	Duocarmycin SA	Others	Others
	Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
T10973	DC41SMe	Others	Others
	DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used for targeted treatment of cancer.
T38710	JH295
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
T83019	Antiproliferative agent-38
	Antiproliferative agent-38（com 18）是一个多环化合物，其中最关键的环氮部分（可能为喹啉）不能进行N-烷基化反应。此化合物不具备抗疟疾活性，也不具有抗癌细胞增殖活性。
T61061	JH295 hydrate
	JH295 hydrate 通过 Cys22 烷基化从而抑制细胞Nek2，它是有效的，不可逆和选择性的NIMA 相关激酶 2 (Nek2)抑制剂 (IC50 = 770 nM)。JH295 hydrate 对有丝分裂激酶 Cdk1，Aurora B 或 Plk1 不具有活性，不干扰双极纺锤体组件或纺锤体组件检查点。
T79665	RUNX-IN-2	Apoptosis	Apoptosis
	RUNX-IN-2 (Compound Conjugate 3) 具有高度特异性，能与RUNX结合序列共价结合并阻断RUNX蛋白与其靶位点的互动。该化合物能诱导p53依赖性细胞凋亡(apoptosis)，抑制细胞增殖，并在PANC-1异种移植小鼠模型中抑制肿瘤生长，显示出高效的烷基化活性。

化合物

Cat.No: T11120

Target: DNA Alkylation, Antibiotic

2-Iodoacetamide

Cat.No: T8897

Synonym: 碘乙酰胺,2-碘乙酰胺,Iodoacetamide

Target: Others

Cat.No: T8330

Synonym: 6-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹噁啉

Target: TGF-beta/Smad

4-Octyl itaconate

Cat.No: T4580

Synonym: 4-辛基衣康酸,衣康酸盐

Target: Nrf2

Cat.No: T0923

Synonym: Myleran,Sulphabutin,白消安,Busulphan

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA Alkylation

Procarbazine hydrochloride

Cat.No: T1488

Synonym: NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T31551

Synonym: DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN

Cat.No: T11118

Target: Others

Cat.No: T10973

Target: Others

Cat.No: T38710

Antiproliferative agent-38

Cat.No: T83019

Cat.No: T61061

Cat.No: T79665

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
T0449	Menadione 维生素K3,Vitamin K3,甲萘醌	Thrombin; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Menadione (Vitamin K3) 是合成的萘醌，能够在体内转化成活性维生素 K2。
T10018	1-Methyladenine	Others	Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac

天然产物

Cat.No: T0449

Synonym: 维生素K3,Vitamin K3,甲萘醌

Target: Thrombin, Endogenous Metabolite

1-Methyladenine

Cat.No: T10018

Target: Others

Masticadienolic acid

Cat.No: TN4505

Target: Others

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