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Search Results for " aim "

Targets Recommended: AIM2 ACK

13

抑制剂 & 化合物

1

天然产物

3

化合物库

19

重组蛋白

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Cat. No.	Product Name
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
L9230	ReFRAME 相关化合物库		3210 compounds
	3210 化合物的独特集合，可用于高通量筛选和高内涵筛选
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

ReFRAME 相关化合物库

Cat.No: L9230

Compounds: 3210

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T5092	AIM-100 AIM100	ACK	Tyrosine Kinase/Adaptors
	AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化，但不抑制其他激酶，包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。
T26582	AIM-102
	AIM-102, a nonsteroidal, immune modulating, anti-inflammatory drug, is used potentially for the treatment of allergic asthma.
T60442	NLRP3/AIM2-IN-3	NOD; AIM2	Immunology/Inflammation; NF-κB
	NLRP3/AIM2-IN-3 是一种独特的分子，能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂，对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解，其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用，抑制了 ASC 的寡聚。
T60404	NLRP3/AIM2-IN-2	AIM2	Immunology/Inflammation
	NLRP3/AIM2-IN-2是一种新型强效抑制剂，对依赖于 NLRP3和 AIM2炎症体的热扩散具有不同物种特异性影响，IC50为0.2392 ± 0.0233 μ M。
T60563	NLRP3/AIM2-IN-1
	NLRP3/AIM2-IN-1是热脓毒症的抑制剂(IC50 = 3.136 ± 0.7667 μM)，显示出适度的反热光活性。
T61326	AIMP2-DX2-IN-1	Others	Others
	AIMP2-DX2-IN-1 是一种有效的 AIMP2-DX2 抑制剂，具有潜在的抗肿瘤活性，可用于研究淋巴癌。
TP1270L	2:PN:US20040072744 SEQID:2 claimed protein acetate 2:PN:US20040072744 SEQID:2 claimed protein acetate(389572-87-6 free base)	Others	Others
	2:PN:US20040072744 SEQID:2 claimed protein acetate 是一种合成肽，用于唐氏综合症和精神分裂症的研究。
TP1270	2: PN: US20040072744 SEQID: 2 claimed protein 2:PN:US20040072744 SEQID:2 claimed protein
	2: PN: US20040072744 SEQID: 2 claimed protein is a synthetic peptide, used for the research of Down’s syndrome and schizophrenia.
T35237	Yamataimine
	Yamataimine is a biochemical.
T27973	MAIM1
	MAIM1 selectively inhibits MCL-1deltaNdeltaC binding activity.
T19997	Daimuron Dymron,Dimuron
	Daimuron is an agent of bioactive chemicals.
T77579	JC2-11	IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2	Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T79435	Metallo-β-lactamase-IN-11
	Metallo-β-lactamase-IN-11（化合物5f）是一种针对Metallo-β-lactamases（MBLs）的抑制剂，对CphA表现出较强的抑制活性（IC50=45 µM）。在10 µM浓度下，能分别抑制49%的NDM-1和61%的AIM-1。此化合物对于研究针对抗生素耐药性的策略具有潜在应用价值。

化合物

Cat.No: T5092

Synonym: AIM100

Target: ACK

Cat.No: T26582

NLRP3/AIM2-IN-3

Cat.No: T60442

Target: NOD, AIM2

NLRP3/AIM2-IN-2

Cat.No: T60404

Target: AIM2

NLRP3/AIM2-IN-1

Cat.No: T60563

AIMP2-DX2-IN-1

Cat.No: T61326

Target: Others

2:PN:US20040072744 SEQID:2 claimed protein acetate

Cat.No: TP1270L

Synonym: 2:PN:US20040072744 SEQID:2 claimed protein acetate(389572-87-6 free base)

Target: Others

2: PN: US20040072744 SEQID: 2 claimed protein

Cat.No: TP1270

Synonym: 2:PN:US20040072744 SEQID:2 claimed protein

Cat.No: T35237

Cat.No: T27973

Cat.No: T19997

Synonym: Dymron,Dimuron

Cat.No: T77579

Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2

Metallo-β-lactamase-IN-11

Cat.No: T79435

Cat. No.	Product Name	Target	Signaling Pathways
T4S0039	Baimaside 白麻苷,Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside	Others	Others
	Baimaside (Quercetin-3-O-sophoroside) 是一种超氧阴离子的清除剂，分离自A. venetum 的花中。

天然产物

Cat.No: T4S0039

Synonym: 白麻苷,Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04232	CD69 Protein, Mouse, Recombinant (His) AIM,AI452015,VEA,5830438K24Rik,CD69 molecule	Mouse	HEK293 Cells
	CD69 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is P37217.
TMPY-04228	CD69 Protein, Mouse, Recombinant (hFc) AIM,VEA,AI452015,5830438K24Rik,CD69 molecule	Mouse	HEK293 Cells
	CD69 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.1 kDa and the accession number is P37217.
TMPY-01569	CD5L Protein, Human, Recombinant (His) PRO229,SP-ALPHA,API6,Spα,CD5 molecule-like,SP-α,Spalpha,...	Human	HEK293 Cells
	CD5L Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.5 kDa and the accession number is O43866.
TMPY-01234	CD69 Protein, Human, Recombinant (His) BL-AC/P26,CLEC2C,GP32/28,AIM,CD69 molecule,MLR-3,EA...	Human	HEK293 Cells
	CD69 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is Q07108.
TMPK-01278	CD69 Protein, Cynomolgus, Recombinant (His) CLEC2C,AIM,EA1,MLR-3,GP32,BL-AC,BL-AC/P26,P26,28,CD...	Cynomolgus	HEK293 Cells
	CLEC2C (CD69) is a membrane-bound, type II C-lectin receptor and acts as a costimulatory molecule for T cell activation and proliferation. It is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. CLEC2C is a disulfide-linked homodimer protein with two differentially glycosylated subunits.
TMPY-01775	AIM2 Protein, Human, Recombinant (GST) absent in melanoma 2,PYHIN4	Human	Baculovirus Insect Cells
	AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting...
TMPY-01461	EMAP-II/AIMP1 Protein, Human, Recombinant (His) SCYE1,p43,EMAPII,aminoacyl tRNA synthetase complex-interacti...	Human	E. coli
	EMAP-II/AIMP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35 kDa and the accession number is Q12904-1.
TMPK-00867	EMAP-II/AIMP1 Protein, Mouse, Recombinant (His) p43,SCYE1,HLD3,EMAP-II,AIMP1,EMAP-2	Mouse	E. coli
	The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely related to the periods of vascularization and alveolarization in the developing lung. Hence the study of EMAP II could play a vital role in studying and devising appropriate therapeutics for diseases of aberrant lung development, such as BPD.
TMPY-03015	EMAP-II/AIMP1 Protein, Mouse, Recombinant AIMP1,p43,Scye1,EMAPII,aminoacyl tRNA synthetase co...	Mouse	E. coli
	EMAP-II/AIMP1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q62386.
TMPH-00927	AIMP2 Protein, Human, Recombinant (His) Protein JTV-1,Aminoacyl tRNA synthase complex-interacting mu...	Human	E. coli
	AIMP2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
TMPY-04020	FCMR/FAIM3 Protein, Human, Recombinant (hFc) FCMR,TOSO,Fc fragment of IgM receptor	Human	HEK293 Cells
	FCMR/FAIM3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53 kDa and the accession number is O60667-1.
TMPK-01019	EPHA5 Protein, Mouse, Recombinant (His) TYRO4,HEK7,EHK-1,EphA5,EK7,BSK,Rek7,EHK1,TYRO4HEK7CEK7	Mouse	HEK293 Cells
	The aim of the present study was to evaluate ephrin type-A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index was statistically analyzed.
TMPK-01031	MAdCAM-1 Protein, Mouse, Recombinant (His) MACAM1,MADCAM1,MAdCAM-1	Mouse	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPK-00976	AMHRII Protein, Human, Recombinant MRII,AMHR2,AMH type II receptor,MIS type II receptor,AMHR,AM...	Human	HEK293 Cells
	The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls. AMHRII Protein, Human, Recombinant is expre...
TMPK-00964	MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated MADCAM1,MAdCAM-1,MACAM1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with...
TMPK-00977	AMHRII Protein, Human, Recombinant (hFc) MISR2,AMHR2,AMH type II receptor,AMHR,C14,MIS type II recept...	Human	HEK293 Cells
	The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls. AMHRII Protein, Human, Recombinant (hFc) is...
TMPK-00965	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) MADCAM1,MACAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) is expressed in HEK293 mammalian cells with C-hFc ta...
TMPK-00966	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) MACAM1,MADCAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) is expressed in HEK293 mammalian cells with C-His ta...

重组蛋白

CD69 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04232

Species: Mouse

Expression System: HEK293 Cells

CD69 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04228

Species: Mouse

Expression System: HEK293 Cells

CD5L Protein, Human, Recombinant (His)

Cat.No: TMPY-01569

Species: Human

Expression System: HEK293 Cells

CD69 Protein, Human, Recombinant (His)

Cat.No: TMPY-01234

Species: Human

Expression System: HEK293 Cells

CD69 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01278

Species: Cynomolgus

Expression System: HEK293 Cells

AIM2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01775

Species: Human

Expression System: Baculovirus Insect Cells

EMAP-II/AIMP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01461

Species: Human

Expression System: E. coli

EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00867

Species: Mouse

Expression System: E. coli

EMAP-II/AIMP1 Protein, Mouse, Recombinant

Cat.No: TMPY-03015

Species: Mouse

Expression System: E. coli

AIMP2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00927

Species: Human

Expression System: E. coli

FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02650

Species: Mouse

Expression System: E. coli

FCMR/FAIM3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04020

Species: Human

Expression System: HEK293 Cells

EPHA5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01019

Species: Mouse

Expression System: HEK293 Cells

MAdCAM-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01031

Species: Mouse

Expression System: HEK293 Cells

AMHRII Protein, Human, Recombinant

Cat.No: TMPK-00976

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00964

Species: Human

Expression System: HEK293 Cells

AMHRII Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00977

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)

Cat.No: TMPK-00965

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His)

Cat.No: TMPK-00966

Species: Human

Expression System: HEK293 Cells

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