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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T76860	Bimagrumab
	Bimagrumab (Anti-ACVR2B Reference Antibody) 是一种人单克隆抗体，可阻断激活素 II 型受体 (ActRII)，对ActRIIB 和ActRIIA 的KD 值分别为 1.7 pM 和 434 pM。Bimagrumab 可用于病理性肌肉损失和无力的研究。

化合物

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Cat. No.	Product Name	Species	Expression System
TMPY-00654	ACVR2B Protein, Human, Recombinant (hFc) activin A receptor, type IIB,HTX4,ActR-IIB,ACTRIIB,Activin R...	Human	HEK293 Cells
	ACVR2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is Q13705-1.
TMPJ-00314	ACVR2B Protein, Human, Recombinant (hFc & His) ACVR2B,Activin Receptor Type IIB,ACTR-IIB,...	Human	HEK293 Cells
	Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, ...
TMPY-01281	ACVR2B Protein, Mouse, Recombinant (His) ActRIIB,activin A receptor, type IIB,4930516B21Rik	Mouse	HEK293 Cells
	ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1.
TMPY-04044	ACVR2B Protein, Cynomolgus, Recombinant activin A receptor, type IIB	Cynomolgus	HEK293 Cells
	ACVR2B Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.1 kDa and the accession number is G7MJ10.
TMPY-03827	ACVR2B Protein, Cynomolgus, Recombinant (His) activin A receptor, type IIB	Cynomolgus	HEK293 Cells
	ACVR2B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa.
TMPY-03925	ACVR2B Protein, Cynomolgus, Recombinant (hFc) activin A receptor, type IIB	Cynomolgus	HEK293 Cells
	ACVR2B Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.3 kDa and the accession number is G7MJ10.
TMPY-01051	ACVR2B Protein, Human, Recombinant (His) ActR-IIB,ACTRIIB,activin A receptor, type IIB,HTX4,Activin R...	Human	HEK293 Cells
	ACVR2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q13705-1.
TMPY-01022	ACVR2B Protein, Mouse, Recombinant (His & hFc) ActRIIB,activin A receptor, type IIB,4930516B21Rik	Mouse	HEK293 Cells
	ACVR2B Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41 kDa and the accession number is P27040-1.
TMPH-01413	GDF11 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. GDF11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression...
TMPH-01015	BMP-3 Protein, Human, Recombinant (His) BMP3A,Bone morphogenetic protein 3A,BMP3,Osteogenin,Bone mor...	Human	E. coli
	Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. BMP-3 Protein, Human, R...