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Search Results for " acat2 "

Targets Recommended: P450 Acyltransferase

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2753	Avasimibe PD-148515,阿伐麦布,CI-1011	P450; Acyltransferase	Metabolism
	Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。
T31611	Eldacimibe WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147	Acyltransferase	Metabolism
	Eldacimibe (WAY-ACA-147) 是一种ACAT2抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，研究动脉粥样硬化和高胆固醇血症。
T12225L	Nevanimibe hydrochloride PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis; Acyltransferase	Apoptosis; Metabolism
	Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。
T11733	K-604 dihydrochloride	Acyltransferase	Metabolism
	K-604 dihydrochloride 是酰基辅酶 A：胆固醇酰基转移酶 1 的选择性抑制剂，IC50为 0.45±0.06 μM。
T62974	Pactimibe sulfate
	Pactimibe sulfate (CS-505) 是一种双重的 ACAT1/2 抑制剂，能够作用于 ACAT1 (IC50: 4.9 μM)、ACAT2 (IC50: 3.0 μM)。Pactimibe sulfate 对 ACAT 表现出抑制作用，在肝细胞中 IC50=2.0 μM，在巨噬细胞中 IC50=2.7 μM，在 THP-1 细胞中 IC50=4.7 μM。Pactimibe sulfate 能够非竞争性地抑制 oleoyl-CoA (Ki: 5.6 μM)，显著抑制胆固醇酯的形成 (IC50: 6.7 μM)。Pactimibe sulfate 能够降低血浆胆固醇的活性，具有抗动脉粥样硬化的潜力。
T12225	Nevanimibe ATR-101,PD-132301	Others	Others
	Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
T28290	Pactimibe CS 505,CS-505,CS505,Pactimibe free base,帕替麦布
	Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity.

化合物

Avasimibe

Cat.No: T2753

Synonym: PD-148515,阿伐麦布,CI-1011

Target: P450, Acyltransferase

Eldacimibe

Cat.No: T31611

Synonym: WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147

Target: Acyltransferase

Nevanimibe hydrochloride

Cat.No: T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

K-604 dihydrochloride

Cat.No: T11733

Synonym:

Target: Acyltransferase

Synonym: ATR-101,PD-132301

Target: Others

Pactimibe

Cat.No: T28290

Synonym: CS 505,CS-505,CS505,Pactimibe free base,帕替麦布

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T12592	Pyripyropene A	Others	Others
	Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM).

天然产物

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01302	ACAT2 Protein, Human, Recombinant (His) ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...	Human	E. coli
	ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...
TMPH-01259	AMFR Protein, Human, Recombinant (His) Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc) gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiquitin-...	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...