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Search Results for " aat "

Targets Recommended: Prostaglandin Receptor

9

抑制剂 & 化合物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0292	Grapiprant AAT-007,RQ-00000007,CJ-023423	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Grapiprant (AAT-007) 是一种选择性EP4 受体拮抗剂，生理配体为前列腺素 E2(PGE2)，有用于骨关节炎疼痛和炎症的研究潜力。它取代 [3H]-PGE2(1 nM) 与狗的重组EP4 受体结合，IC50为 35 nM，Ki 为 24 nM。
T26497	AAT-008 AAT008
	AAT-008 is a PGE2 receptor EP4 antagonist.
T9347	EAAT2 activator 1 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine	transporter	Metabolism
	EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) 是兴奋性氨基酸转运蛋白 2(EAAT2) 的有效激活剂，以剂量依赖性方式增加 EAAT2 蛋白水平。
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT 是一种由荧光分子5'6-FAM修饰的双链核糖核酸。其中，5'6-FAM实际为5-FAM与6-FAM的混合物，其激发和发射光谱的特征值分别为Ex/Em= 490 nm/520 nm。
T83297	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT
	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT 是带有荧光素 FAM 标记的寡核苷酸。
T39397	S-MGB-234
	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.
T73993	Fazirsiran
	Fazirsiran (ARO-AAT) 是第二代 RNA 干扰 (RNAi) 活性分子。Fazirsiran 由胆固醇偶联的 RNAi 触发器 (chol-RNAi) 组成，通过 RNAi 选择性降解 AAT mRNA，以及与 N-乙酰半乳糖胺 (NAG) 偶联的蜂毒肽衍生肽配制成赋形剂 EX1，促进肝细胞内 chol RNAi 的内体逃逸。
T60642	SN40
	SN40 是一种有效的氨基酸转运 (AAT)抑制剂，对人 ASCT1、大鼠 ASCT2、人 ASCT2、EAAT1、EAAT2、EAAC1 和 EAAT5 的Ki 分别为 7.29 μM、2.42 μM、2.94 μM、5.55 μM、24.43 μM 和 5.55 μM。SN40 可用于抗癌研究。
T60768	SN05
	SN05 是可用于抗癌研究的，氨基酸转运 (AAT)的有效抑制剂。SN05 对人 ASCT1、大鼠 ASCT2、人 ASCT2、EAAT1、EAAT2、EAAC1 和 EAAT5 的Ki 值分别为2.77 μM、0.73 μM、0.87 μM、3.7 μM、7.25 μM、7.23 μM 和 2.22 μM。

化合物

Cat.No: TQ0292

Synonym: AAT-007,RQ-00000007,CJ-023423

Target: Prostaglandin Receptor

Cat.No: T26497

Synonym: AAT008

EAAT2 activator 1

Cat.No: T9347

Synonym: 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine

Target: transporter

5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT

Cat.No: T83298

5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT

Cat.No: T83297

Cat.No: T39397

Cat.No: T73993

Cat.No: T60642

Cat.No: T60768

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His) PRO2275,SerpinA1,serpin peptidase inhibitor, clade A (alpha-...	Human	HEK293 Cells
	Serpin A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is P01009-1.
TMPJ-00505	Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1...	Human	HEK293 Cells
	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re...
TMPJ-00452	Serpin A1a Protein, Mouse, Recombinant (His) Alpha-1-antitrypsin 1-1, Alpha-1 protease inhibitor 1, Alpha...	Mouse	HEK293 Cells
	Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi) tbetaR-I,TGFβRI,TGFbetaRI,LDS2A,ALK-5,TGF-beta RI,tβR-I,TGF-...	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1.
TMPY-05157	TGFBR2 Protein, Human, Recombinant (His) LDS2B,FAA3,TAAD2,MFS2,TGFR-2,TGFbeta-RII,transforming growth...	Human	Baculovirus Insect Cells
	TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.
TMPY-03052	MFAP5 Protein, Human, Recombinant (His) microfibrillar associated protein 5,MFAP-5,AAT9,MAG...	Human	HEK293 Cells
	MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycoprotein, MFAP5 is rich in serine and threonine residues. It stimulates the assembly of elastic fibers, a complex structure composed of a tropoelastin inner core and microfibril outer mantle comprising proteins such as fibrillins and microfibril-associated glycoproteins that guide ...
TMPK-01217	MFAP5 Protein, Mouse, Recombinant (hFc) MP25,AAT9,MAGP2,MAGP-2,MFAP-5	Mouse	HEK293 Cells
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC. MFAP5 Protein,...
TMPK-00957	MFAP5 Protein, Human, Recombinant (hFc) MAGP2,AAT9,MAGP-2,MP25,MFAP-5	Human	HEK293 Cells
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC. MFAP5 Protein,...
TMPK-00328	TGFBR2 Protein, Human, Recombinant (mFc & Avi) TAAD2,LDS2B,LDS2,MFS2,TGFBR2,AAT3,LDS1B,TGFβR2,Tbet...	Human	HEK293 Cells
	The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The pred...
TMPK-00329	TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated LDS2B,TbetaR-II,TGFβR2,LDS2,RIIC,TGF-β RII/TGFBR2,TβR-II,TGF...	Human	HEK293 Cells
	The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi...
TMPK-00306	TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated TGFbetaRI,TGFBR1,ALK-5,SKR4,LDS2A,TGFB1R1,LDS1A,AAT...	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is...
TMPY-04366	ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) LDS1,ALK-5,LDS2A,AAT5,SKR4,transforming growth fact...	Human	Baculovirus Insect Cells
	ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.6 kDa and the accession number is P36897-1.
TMPY-05508	TGFBR2 Protein, Human, Recombinant (hFc) TGFβ-RII,TGFbeta-RII,MFS2,AAT3,transforming growth ...	Human	HEK293 Cells
	TGFBR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is P37173.
TMPY-05810	TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated RIIC,TAAD2,AAT3,TGFβ-RII,FAA3,transforming growth f...	Human	HEK293 Cells
	TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P37173.
TMPY-05771	ALK-5 Protein, Human, Recombinant (hFc) AAT5,SKR4,TGFR-1,LDS1,transforming growth factor, b...	Human	HEK293 Cells
	ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
TMPY-01358	ALK-5 Protein, Human, Recombinant (His & hFc) tβR-I,ALK5,AAT5,TGFR-1,LDS2A,LDS1,transforming grow...	Human	HEK293 Cells
	ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.
TMPJ-01178	TGFBR1 Protein, Mouse, Recombinant (hFc) ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1A,TGFbetaRI,TGFB1R1,activin...	Mouse	HEK293 Cells
	TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...

重组蛋白

Serpin A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00915

Species: Human

Expression System: HEK293 Cells

Serpin A1 Protein, Human, Recombinant (aa 25-418, His)

Cat.No: TMPJ-00505

Species: Human

Expression System: HEK293 Cells

Serpin A1a Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00452

Species: Mouse

Expression System: HEK293 Cells

TGFBR1 Protein, Human, Recombinant (mFc & Avi)

Cat.No: TMPK-00305

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05157

Species: Human

Expression System: Baculovirus Insect Cells

MFAP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-03052

Species: Human

Expression System: HEK293 Cells

MFAP5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01217

Species: Mouse

Expression System: HEK293 Cells

MFAP5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00957

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Human, Recombinant (mFc & Avi)

Cat.No: TMPK-00328

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated

Cat.No: TMPK-00329

Species: Human

Expression System: HEK293 Cells

TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated

Cat.No: TMPK-00306

Species: Human

Expression System: HEK293 Cells

ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)

Cat.No: TMPY-04366

Species: Human

Expression System: Baculovirus Insect Cells

TGFBR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05508

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated

Cat.No: TMPY-05810

Species: Human

Expression System: HEK293 Cells

ALK-5 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05771

Species: Human

Expression System: HEK293 Cells

ALK-5 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01358

Species: Human

Expression System: HEK293 Cells

TGFBR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01178

Species: Mouse

Expression System: HEK293 Cells

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