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23

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension...
T40048	MC-AAA-NHCH2OCH2COOH MC-AAA-NHCH2OCH2COOH
	MC-AAA-NHCH2OCH2COOH (compound 20) is a cleavable antibody-drug conjugate (ADC) linker. Its primary application lies in the synthesis of ADCs.
T40049	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a monoclonal antibody (mAb).
T63060	AAA-10
	AAA-10 是一种口服具有活力的肠道细菌胆盐水解酶 (BSH) 抑制剂，能够作用于 B. thetarBSH (IC50: 10 nM) 和 B. longumrBSH (IC50: 80 nM)。
T63616	AAA-10 formic
	AAA-10 formic 是口服具有活力的肠道细菌胆盐水解酶 (BSH) 抑制剂，对B. thetarBSH (IC50: 10 nM) 和B. longumrBSH (IC50: 80 nM)。
T8513	Spastazoline	Others	Others
	Spastazoline 是spastin(一种微管切断AAA 蛋白) 的选择性抑制剂，对人 spastin 的IC50值为 99 nM。它不能影响重组人 VPS4 的 ATPase 活性。
T6796	CB-5083 CB5083,CB 5083	p97	Ubiquitination
	CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂，IC50为 11 nM。
T9882	RUVBL1/2 ATPase-IN-1	Others	Others
	RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂，IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。
T60432	NAAA-IN-3
	NAAA-IN-3 (Compound 17a) 是一种有效的、选择性的 NAAA 抑制剂，IC50为 50 nM。NAAA 是一种半胱氨酸酰胺酶，它优先水解内源性生物脂棕榈酰乙醇酰胺 (PEA) 和油酰乙醇酰胺 (OEA)。PEA 是核过氧化物酶体增殖物激活受体-α (PPAR-α) 的内源性激动剂，PPAR-α 是炎症和疼痛的关键调节因子。 NAAA-IN-3 的潜在作用是作为炎症和疼痛的治疗剂。
T60378	NAAA-IN-2
	NAAA-IN-2 (Compound 9) 是一种有效的、选择性的NAAA 抑制剂，IC50为 50 nM。NAAA 是一种半胱氨酸酰胺酶，优先水解内源性生物脂棕榈酰乙醇酰胺 (PEA) 和油酰乙醇酰胺 (OEA)。NAAA-IN-2 在炎症和疼痛的研究中具有潜力。
T60767	NAAA-IN-1
	NAAA-IN-1 (Compound 1) 可用于炎症和疼痛的研究。NAAA-IN-1 是NAAA 的选择性抑制剂 (IC50 = 7 nM)。NAAA 优先水解内源性生物脂棕榈酰乙醇酰胺 (PEA) 和油酰乙醇酰胺 (OEA)，是一种半胱氨酸酰胺酶。
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT 是一种由荧光分子5'6-FAM修饰的双链核糖核酸。其中，5'6-FAM实际为5-FAM与6-FAM的混合物，其激发和发射光谱的特征值分别为Ex/Em= 490 nm/520 nm。
T14965	Ciliobrevin D	ATPase; Hedgehog/Smoothened	GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Ciliobrevin D 是细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
T28506	Rbin-2	Phosphatase	Metabolism
	Rbin-2 是一种具有细胞渗透性、强效性、选择性和可逆性的 Midasin(Mdn1) 抑制剂。Rbin-2 直接靶向 AAA+ ATPase Midasin，抑制真核生物核糖体的生成，是研究真核生物核糖体组装过程的强效探针。
T5425	ML367	Epigenetic Reader Domain	Chromatin/Epigenetic
	ML367 是一种稳定的、有效的 ATPase 家族 AAA 结构域蛋白 5 抑制剂，是一个探针分子，具有低摩尔抑制浓度。它可以阻断 DNA 的修复通路，抑制一般的 DNA 损伤反应，包括应对紫外照射产生的 RPA32 和 CHK1 的磷酸化。
T72043	SCFSkp2-IN-2	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SCFSkp2-IN-2 是一种 Skp2抑制剂，其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T9008	NPD8733	Others	Others
	NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员，能够与含 valosin 的蛋白 (VCP)/p97特异性结合，对癌症疾病具有潜在的研究价值。
T29068	UPCDC-30245 UPCDC 30245
	UPCDC30245 is an AAA ATPase p97 allosteric inhibitor.
T12114	MSC1094308	p97	Ubiquitination
	MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.
T39008	PRMT5-IN-4 PRMT5-IN-4
	PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.
T27165	Diazaborine Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
	Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to t
T74446	OF-02
	OF-02 是一种可电离的脂质，可在体内高效传递 mRNA。
T77820	7-Aminomethyl-10-methyl-11-fluoro camptothecin
	7-Aminomethyl-10-methyl-11-fluoro camptothecin为MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin的毒素分子，适用于喜树碱ADC的制备。

化合物

Cat.No: T35855

MC-AAA-NHCH2OCH2COOH

Cat.No: T40048

Synonym: MC-AAA-NHCH2OCH2COOH

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T40049

Synonym: MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T63060

AAA-10 formic

Cat.No: T63616

Cat.No: T8513

Target: Others

Cat.No: T6796

Synonym: CB5083,CB 5083

Target: p97

RUVBL1/2 ATPase-IN-1

Cat.No: T9882

Target: Others

Cat.No: T60432

Cat.No: T60378

Cat.No: T60767

5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT

Cat.No: T83298

Cat.No: T14965

Target: ATPase, Hedgehog/Smoothened

Cat.No: T28506

Target: Phosphatase

Cat.No: T5425

Target: Epigenetic Reader Domain

Cat.No: T72043

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T9008

Target: Others

Cat.No: T29068

Synonym: UPCDC 30245

Cat.No: T12114

Target: p97

Cat.No: T39008

Synonym: PRMT5-IN-4

Cat.No: T27165

Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474

Cat.No: T74446

7-Aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T77820

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03263	RUVBL1 Protein, Human, Recombinant (His) TIH1,ECP54,TIP49,RuvB-like AAA ATPase 1,PONTIN,TIP4...	Human	Baculovirus Insect Cells
	RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. RUVBL1 is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. RUVBL1 plays an essential role in oncogenic transformati...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,C...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPY-03884	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) CTFgamma,PN-II,AAA,Aβ,PN2,APPI,AD1,amyloid beta (A4...	Human	E. coli
	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.2 kDa and the accession number is P05067-1.
TMPY-03885	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) AD1,AAA,ABETA,CVAP,PN-II,CTFgamma,Aβ,APPI,PN2,CTFγ,...	Human	E. coli
	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.1 kDa and the accession number is P05067-1.
TMPY-02110	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) AD1,ABPP,CTFγ,APPI,ABETA,β-amyloid 40/β-APP40,Aβ,CVAP,CTFgam...	Human	E. coli
	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 31.8 kDa and the accession number is P05067-1.
TMPY-02221	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) CVAP,PN2,amyloid β (A4) precursor protein,Aβ,CTFγ,β-amyloid ...	Human	E. coli
	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.4 kDa and the accession number is P05067-1.
TMPH-03181	LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO)	Pseudomonas azotoformans	E. coli
	Hydrolyzes L-prolinamide, L-proline-p-nitroanilide, L-alaninamide, L-methioninamide, piperidine-2-carboxamide and piperazine-2-carboxamide. Has a much lower activity towards piperazine-2-tert-butylcarboxamide. Does not hydrolyze dipeptides and D-prolinamide. LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 54.5 kDa and the accession number is Q76KX0.
TMPJ-01013	VCP Protein, Human, Recombinant (His) TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...

重组蛋白

RUVBL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03263

Species: Human

Expression System: Baculovirus Insect Cells

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)

Cat.No: TMPY-03884

Species: Human

Expression System: E. coli

Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)

Cat.No: TMPY-03885

Species: Human

Expression System: E. coli

Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02110

Species: Human

Expression System: E. coli

Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02221

Species: Human

Expression System: E. coli

LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03181

Species: Pseudomonas azotoformans

Expression System: E. coli

VCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01013

Species: Human

Expression System: E. coli

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