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Search Results for " a8 "

Targets Recommended: Calcium Channel

24

抑制剂 & 化合物

24

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T71990	TTA-A8	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	TTA-A8 是 T 型钙通道的拮抗剂。
T125235	Scrophularoside A8
	Scrophularoside A8 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125235，CAS号为 240820-44-4。
T124118	Iturin A8
	Iturin A8 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124118，CAS号为 83856-07-9。
TF0054	Biotinylated A8-35
	Biotinylated A8-35 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0054，CAS号为 1423685-21-5。
TF0050	Amphipol A8-35
	Amphipol A8-35 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0050，CAS号为 326856-53-5。
T71382	KRC-108
	KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo...
T60167	Eubulus-A80	Others	Others
	Eubulus-A80是抗肿瘤化合物（WO2021/183702, Compound A80）。
T11762L	Kira8 AMG-18	IRE1	Cell Cycle/Checkpoint
	Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂，可变构减弱 IRE1α RNase 活性，IC50为 5.9 nM。
T39482	Casein Kinase inhibitor A86 Casein Kinase inhibitor A86
	Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α). Additionally, it displays inhibitory actions towards CDK7 (TFIIH) and CDK9 (P-TEFb). Furthermore, Casein Kinase inhibitor A86 demonstrates the ability to induce apoptosis in leukemia cells, portraying substantial anti-leukemic effects.
T76635	(Trp7,β-Ala8)-Neurokinin A (4-10)
	(Trp7,β-Ala8)-Neurokinin A (4-10) 是一种有效的neurokinin-3 (NK3)拮抗剂。
T70223	UA8967
	UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane.
T63446	PKRA83
	PKRA83 是一种能够透过血脑屏障的 potent prokineticin (PK2) 拮抗剂，可竞争 PK2 与其受体 PKR1 和 PKR2 的结合。PKRA83 能够有效抑制 PK2 受体，可作用于 PKR1 (IC50: 5.0 nM) 和 PKR2 (IC50: 8.2 nM)。PKRA83 表现出抗癌和抗血管生成作用。
TP1100	[bAla8]-Neurokinin A(4-10) MEN 10210
	[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.
T28851	SRA880 free base SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880
	SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 re
T11762	Kira8 Hydrochloride AMG-18 Hydrochloride	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
T21869	BW A868C
	BW A868C 是一种乙内酰脲化合物，是 BW245C 结构类似物。BW A868C 是一种选择性强的前列腺素 D2 (PGD2) 竞争性拮抗剂。BW A868C 对其他前列腺素受体 (IP、EP1、EP2、TP 和 FP) 没有影响。
T81445	PKRA83 hydrochloride hydrate PKRA7 hydrochloride hydrate
	PKRA83 hydrochloride hydrate是一种高效的促动力拮抗剂，与PK2及其受体PKR1和PKR2进行竞争性结合。该化合物在抑制PK2受体方面表现出色，其对PKR1和PKR2的IC50值分别为5.0 nM和8.2 nM。此外，PKRA83 hydrochloride hydrate还具备抗癌、抗关节炎以及抗血管生成的活性，并能够穿透血脑屏障。
T80305	A8SGLP-1
	A8SGLP-1，一种口服活性GLP-1类似物，特点是其8位丙氨酸被丝氨酸替换。在不干扰功能的前提下，A8SGLP-1能有效降低db/db小鼠的血糖水平。
T73580	8A8	NO Synthase	Immunology/Inflammation
	8A8 作为促炎因子NO的有效抑制剂，具有4.7 μM的 IC50 值，并显著抑制由 LPS 诱导的 HaCat 细胞增殖。
T26225	SRA880 malonate SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880
	SRA880 is a non-peptide somatostatin sst(1) receptor antagonist which displays a significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d)= 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine
T76428	(β-Ala8)-Neurokinin A (4-10)
	(β-Ala8)-Neurokinin A (4-10) 是一种神经肽，是一种有效的选择性 NK-2(Neurokinin Receptor) 速激肽受体激动剂。
T80306	A8SGLP-1 TFA
	A8SGLP-1 TFA为口服活性GLP-1类似物，8位丙氨酸被丝氨酸替代。在不干扰功能的前提下，可降低db/db小鼠血糖水平。
T14079	A81988 Abbott81988	Others	Others
	A81988 is an antagonist of angiotensin AT1 receptors.
T79581	JAK2-IN-9	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-9（Compound A8）是一款选择性JAK2抑制剂（IC50：5 nM），能够抑制JAK2、STAT3和STAT5的磷酸化，并显示出代谢稳定性。此外，JAK2-IN-9能够诱导细胞凋亡（apoptosis），适用于骨髓增生性肿瘤（MPN）的研究。

化合物

Cat.No: T71990

Target: Calcium Channel

Scrophularoside A8

Cat.No: T125235

Cat.No: T124118

Biotinylated A8-35

Cat.No: TF0054

Cat.No: TF0050

Cat.No: T71382

Cat.No: T60167

Target: Others

Cat.No: T11762L

Synonym: AMG-18

Target: IRE1

Casein Kinase inhibitor A86

Cat.No: T39482

Synonym: Casein Kinase inhibitor A86

(Trp7,β-Ala8)-Neurokinin A (4-10)

Cat.No: T76635

Cat.No: T70223

Cat.No: T63446

[bAla8]-Neurokinin A(4-10)

Cat.No: TP1100

Synonym: MEN 10210

SRA880 free base

Cat.No: T28851

Synonym: SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880

Kira8 Hydrochloride

Cat.No: T11762

Synonym: AMG-18 Hydrochloride

Target: Adenosine Receptor

Cat.No: T21869

PKRA83 hydrochloride hydrate

Cat.No: T81445

Synonym: PKRA7 hydrochloride hydrate

Cat.No: T80305

Cat.No: T73580

Target: NO Synthase

SRA880 malonate

Cat.No: T26225

Synonym: SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880

(β-Ala8)-Neurokinin A (4-10)

Cat.No: T76428

Cat.No: T80306

Cat.No: T14079

Synonym: Abbott81988

Target: Others

Cat.No: T79581

Target: JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00585	Annexin A8 Protein, Human, Recombinant (His) ANX8,annexin A8	Human	E. coli
	We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ...
TMPJ-00504	Serpin A8 Protein, Human, Recombinant (His) AGT and SERPINA8,Angiotensinogen,Serpin A8	Human	HEK293 Cells
	Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TMPK-01470	HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi) MAGE-A4 or MAGE-A8,MAGE-A8,MAGE-A4	Human	HEK293 Cells
	MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 antigen-presenting peptides can be presented by HLA-A*02:01.
TMPK-01459	HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi), Biotinylated MAGE-A4 or MAGE-A8,MAGE-A8,MAGE-A4	Human	HEK293 Cells
	MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 antigen-presenting peptides can be presented by HLA-A*02:01.
TMPY-01356	S100A8 Protein, Human, Recombinant (His) 60B8AG,MRP-8,MA387,NIF,L1Ag,S100 calcium binding protein	Human	Baculovirus Insect Cells
	S100A8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is P05109.
TMPY-04896	EphA8 Protein, Human, Recombinant (hFc) EK3,EPH receptor A8,EEK,HEK3	Human	HEK293 Cells
	EphA8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.6 kDa and the accession number is P29322-1.
TMPJ-00396	SEMA4D Protein, Human, Recombinant (aa 22-734, His) A8,BB18,Semaphorin-4D,GR3,CD100	Human	HEK293 Cells
	Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells, regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/P...
TMPJ-00991	S100A8 Protein, Rat, Recombinant (His) Leukocyte L1 complex light chain,Migration inhibitory factor...	Rat	E. coli
	Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. It may function in the inhi...
TMPY-03556	S100A8 Protein, Mouse, Recombinant (His) p8,S100 calcium binding protein A8,Caga,60B8Ag,B8Ag...	Mouse	E. coli
	S100A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P27005.
TMPJ-00844	ANXA8 Protein, Human, Recombinant Vascular Anticoagulant-β,Annexin-8,Annexin A8,VAC-B...	Human	E. coli
	Annexin A8 (ANXA8) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats may form one binding site for calcium and phospholipid. ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells, which suggests its participation in hematopoietic cell differentiation. In addition, ANXA8 is an anticoagulant protein that acts as an indirect i...
TMPJ-00406	EphA8 Protein, Human, Recombinant (His) EPH- and ELK-related tyrosine kinase,EPH receptor A8	Human	HEK293 Cells
	EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent c...
TMPJ-00591	CCL8 Protein, Human, Recombinant (His) SCYA8,MCP-2,Monocyte Chemotactic Protein 2,C-C Moti...	Human	HEK293 Cells
	CCL8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 13 KDa and the accession number is AAI26243.1.
TMPJ-00010	CCL8 Protein, Human, Recombinant Monocyte Chemoattractant Protein 2,C-C Motif Chemokine 8,MCP...	Human	E. coli
	CCL8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12 KDa and the accession number is P80075.
TMPY-04290	S100A8 & S100A9 Heterodimer Protein, Human, Recombinant (Flag & His) S1A8,CAGA,CFAG,CAGB,MRP8 & S1A9,MRP14	Human	Baculovirus Insect Cells
	S100A8 & S100A9 Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in Baculovirus insect cells with Flag and His tag. The predicted molecular weight is 12.2 kDa and the accession number is NP_002955.2&NP_002956.1.
TMPK-01151	MXRA8 Protein, Human, Recombinant (His) Asp3,Limitrin,Adipocyte-specific 3,DICAM,Adipocyte-specific ...	Human	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.70 kDa and the accession number is Q9BRK3-1.
TMPY-00638	Interferon alpha B/IFNA8 Protein, Human, Recombinant (His) IFN-αB,IFN-alphaB,interferon, α8,Interferon α-B,interferon, ...	Human	HEK293 Cells
	Interferon alpha B/IFNA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is A0A7R8C381.
TMPY-05953	SARS-CoV-2 Spike S1+S2 ECD Protein (R683A & R685A & F817P & A892P & A899P & A942P & K986P & V987P, His)	SARS-CoV-2	HEK293 Cells
	SARS-CoV-2 Spike S1+S2 ECD Protein (R683A & R685A & F817P & A892P & A899P & A942P & K986P & V987P, His) is expressed in HEK293 mammalian cells. The predicted molecular weight is 138.5 kDa and the accession number is A0A6G7K2L4.
TMPH-02979	SLC30A8 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.0 kDa and the accession number is Q8BGG0.
TMPY-03637	Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (His) Interferon α-B,interferon, alpha 8,interferon, α8	Cynomolgus	HEK293 Cells
	Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43 kDa and the accession number is G7PS89.
TMPY-03620	Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (mFc) Interferon α-B,interferon, alpha 8,interferon, α8	Cynomolgus	HEK293 Cells
	Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46 kDa and the accession number is G7PS89.
TMPK-01166	MXRA8 Protein, Mouse, Recombinant (His) Asp3,DICAM,Adipocyte-specific protein 3,Adipocyte-specific 3...	Mouse	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.11 kDa and the accession number is Q9DBV4.
TMPH-01427	HSPA8 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	HSPA8 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-03648	Interferon alpha B/IFNA8 Protein, Human, Recombinant IFN-αB,IFN-alphaB,interferon, alpha 8,Interferon α-B,interfe...	Human	HEK293 Cells
	Interferon alpha B/IFNA8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38 kDa and the accession number is A0A7R8C381.
TMPH-02323	SLC30A8 Protein, Human, Recombinant (His)	Human	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q8IWU4.

重组蛋白

Annexin A8 Protein, Human, Recombinant (His)

Cat.No: TMPY-00585

Species: Human

Expression System: E. coli

Serpin A8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00504

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01470

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01459

Species: Human

Expression System: HEK293 Cells

S100A8 Protein, Human, Recombinant (His)

Cat.No: TMPY-01356

Species: Human

Expression System: Baculovirus Insect Cells

EphA8 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04896

Species: Human

Expression System: HEK293 Cells

SEMA4D Protein, Human, Recombinant (aa 22-734, His)

Cat.No: TMPJ-00396

Species: Human

Expression System: HEK293 Cells

S100A8 Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00991

Species: Rat

Expression System: E. coli

S100A8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03556

Species: Mouse

Expression System: E. coli

ANXA8 Protein, Human, Recombinant

Cat.No: TMPJ-00844

Species: Human

Expression System: E. coli

EphA8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00406

Species: Human

Expression System: HEK293 Cells

CCL8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00591

Species: Human

Expression System: HEK293 Cells

CCL8 Protein, Human, Recombinant

Cat.No: TMPJ-00010

Species: Human

Expression System: E. coli

S100A8 & S100A9 Heterodimer Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-04290

Species: Human

Expression System: Baculovirus Insect Cells

MXRA8 Protein, Human, Recombinant (His)

Cat.No: TMPK-01151

Species: Human

Expression System: HEK293 Cells

Interferon alpha B/IFNA8 Protein, Human, Recombinant (His)

Cat.No: TMPY-00638

Species: Human

Expression System: HEK293 Cells

SARS-CoV-2 Spike S1+S2 ECD Protein (R683A & R685A & F817P & A892P & A899P & A942P & K986P & V987P, His)

Cat.No: TMPY-05953

Species: SARS-CoV-2

Expression System: HEK293 Cells

SLC30A8 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02979

Species: Mouse

Expression System: E. coli

Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-03637

Species: Cynomolgus

Expression System: HEK293 Cells

Interferon alpha B/IFNA8 Protein, Cynomolgus, Recombinant (mFc)

Cat.No: TMPY-03620

Species: Cynomolgus

Expression System: HEK293 Cells

MXRA8 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01166

Species: Mouse

Expression System: HEK293 Cells

HSPA8 Protein, Human, Recombinant (His)

Cat.No: TMPH-01427

Species: Human

Expression System: P. pastoris (Yeast)

Interferon alpha B/IFNA8 Protein, Human, Recombinant

Cat.No: TMPY-03648

Species: Human

Expression System: HEK293 Cells

SLC30A8 Protein, Human, Recombinant (His)

Cat.No: TMPH-02323

Species: Human

Expression System: E. coli

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