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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27836	Linadryl hydrochloride A 446,A446,A-446	Others	Others
	Linadryl hydrochloride may have antihistamine activity.
T6739	Zoledronic Acid CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis; Rho; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐，能抑制破骨细胞的分化和凋亡，具有高效的抗骨质再吸收活性，也有抗癌作用。
T2649	Menin-MLL inhibitor MI-2 Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。
T7000	Tiagabine hydrochloride NO328 hydrochloride,盐酸噻加宾,NO050328 hydrochloride,TGB hydrochloride,Gabitril,Gabitril hydrochloride	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Tiagabine hydrochloride (NO050328 hydrochloride) 是具有抗惊厥特性的选择性GABA 再摄取抑制剂，在突触体、神经元和神经胶质中，能够抑制 [3H]GABA 的重摄取，IC50值分别为 67、446 和 182 nM。
T11977	Mcl1-IN-9	BCL	Apoptosis
	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
T75302	(S)-Dinotefuran	Others	Others
	(S)-Dinotefuran ((S)-MTI-446)，新型烟碱类杀虫剂，主要通过与蜜蜂Apis mellifera (Apis mellifera Linnaeus)的nAChRα8亚基结合发挥毒效，其对Apis mellifera的毒性超过R-Dinotefuran。
T67467	2-Amino-4-fluorobenzoic acid	Others	Others
	2-Amino-4-fluorobenzoic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67467，CAS号为 446-32-2。
T75301	(R)-Dinotefuran	Others	Others
	(R)-Dinotefuran ((R)-MTI-446) 是一种新烟碱类农药，与消旋混合物相比，通过抑制烟碱乙酰胆碱受体 (nAChR) 对典型的吸吮性害虫Aphis gossypii 和Apolygus lucorum 表现出相当的杀虫活性 (1.7-2.4 倍)。(R)-Dinotefuran 具有良好的防治目标害虫的作用，同时减少对蜜蜂的危害。
T37049	monoMICAAc	Others	Others
	monoMICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of monoMICAAc increases. It displays excitation/emission maxima of 425/491, 437/515, and 472/554 nm in hexane, dioxane, and water, respectively. The absorption maximum of monoMICAAc decreases with increasing pH. It displays absorbance/emission maxima of 475/553 and 446/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increa...
T62382	Tiagabine hydrochloride hydrate	Others	Others
	Tiagabine hydrochloride hydrate 是一种有效、选择性的 GABA uptake 抑制剂；在突触体、神经元和神经胶质中，能够抑制 [3H] GABA 的摄取，他们的 IC50 值分别为 67，446 和 182 nM。Tiagabine hydrochloride hydrate 能够用作抗惊厥剂。
T37740	N-Demethylvancomycin (hydrochloride)	Others	Others
	N-Demethylvancomycin is a glycopeptide antibiotic that has been found inNocardia orientalis.1It is active against several strains ofS. aureusandS. epidermidisin vitroandin vivo.2Formulations containing N-demethylvancomycin have been used in the treatment of bacterial infections. 1.Boeck, L.D., Mertz, F.P., Wolter, R.K., et al.N-demethylvancomycin, a novel antibiotic produced by a strain of Nocardia orientalis. Taxonomy and fermentationJ. Antibiot. (Tokyo)37(5)446-453(1984) 2.Hunt, A.H., Marconi,...

化合物

Linadryl hydrochloride

Cat.No: T27836

Synonym: A 446,A446,A-446

Target: Others

Zoledronic Acid

Cat.No: T6739

Synonym: CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa

Target: Apoptosis, Rho, Autophagy

Menin-MLL inhibitor MI-2

Cat.No: T2649

Synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Tiagabine hydrochloride

Cat.No: T7000

Synonym: NO328 hydrochloride,盐酸噻加宾,NO050328 hydrochloride,TGB hydrochloride,Gabitril,Gabitril hydrochloride

Target: GABA Receptor

2-Amino-4-fluorobenzoic acid

Tiagabine hydrochloride hydrate

Cat.No: T62382

Synonym:

Target: Others

N-Demethylvancomycin (hydrochloride)

Cat.No: T37740

Synonym:

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T35513	13C15-Nivalenol 13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026...

同位素

13C15-Nivalenol

Cat.No: T35513

Synonym: 13C15-Nivalenol

Target:

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