Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3089 |
6-Thioguanine
6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine,6-硫代鸟嘌呤 |
Apoptosis; DNA Methyltransferase; SARS-CoV; Endogenous Metabolite; DUB; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Ubiquitination |
6-Thioguanine (2-Amino-6-purinethiol) 是一种抗白血病和免疫抑制剂,是 SARS 和 MERS 冠状病毒木瓜样蛋白酶抑制剂,也抑制 USP2的活性,IC50值分别为 25 μM 和 40 μM。 | |||
T67864 |
TH1760
MKB |
NUDIX hydrolase | Metabolism |
TH1760 (MKB) 是有效的 NUDIX-type 15 (NUDT15) 抑制剂 (IC50= 25 nM)。TH1760 可以通过增强核酸中 6-thio-(d) GTP 的积累增加细胞对 6-硫代鸟嘌呤的敏感程度。TH1760 增强了硫基嘌呤的抗白血病作用。 | |||
T70304 |
CI-898 HCl
|
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CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia. |