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Search Results for " α-glucosidase-in-2 "

10

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61249	α-Glucosidase-IN-2
	α-Glucosidase-IN-2 (compound 5d) 是一种有效的α-Glucosidase 抑制剂，IC50of 9.48 μM。α-Glucosidase-IN-2 是一种抗糖尿病药物。
T61706	α-Amylase/α-Glucosidase-IN-2
	α-Amylase/α-Glucosidase-IN-2 (compound 5) exhibits strong inhibition activity towards both α-amylase and α-glucosidase enzymes, with IC 50 values of 13.02 μM and 13.09 μM, respectively. This compound shows promise for investigating diabetic complications [1].
T67898	α-Glucosidase-IN-22	Glucosidase	Metabolism
	α-Glucosidase-IN-22是一种α-葡萄糖苷酶选择性抑制剂（IC50=0.64 μM）。α-Glucosidase-IN-22有抗糖尿病的活性，在2型糖尿病(T2DM)研究中具有潜力。
T78864	α-Glucosidase-IN-33	Glucosidase	Metabolism
	α-Glucosidase-IN-33 (compound 7c) 是一种有效的α-葡萄糖苷酶抑制剂，IC50值为2.39 μM，主要用于2型糖尿病及高血糖研究。
T78865	α-Glucosidase-IN-34	Glucosidase	Metabolism
	α-Glucosidase-IN-34 (compound 7f) 作为一种有效的α-葡萄糖苷酶抑制剂，具有2.90 μM的IC50值，主要用于2型糖尿病和高血糖的研究。
T79237	α-Glucosidase-IN-27	Glucosidase	Metabolism
	α-Glucosidase-IN-27（化合物8l）是一种有效的α-glucosidase抑制剂，其IC50值为25.78 μM。该化合物有望用于研究2型糖尿病（D2M）。
T78731	α-Glucosidase-IN-26	Glucosidase	Metabolism
	α-Glucosidase-IN-26（化合物 7i）是一种有效的α-glucosidase抑制剂，其半抑制浓度（IC50）为4.63 µM，适用于2型糖尿病（T2DM）的研究。
T79318	α-Glucosidase-IN-30	Glucosidase	Metabolism
	α-Glucosidase-IN-30 (compound 8c) 是竞争性的α-glucosidase抑制剂，口服活性强，Ki值为40.0 µM，IC50值为49.0 µM。该化合物对MCF-7和HDF细胞系无细胞毒性，适合用于2型糖尿病研究。
T78881	α-Glucosidase-IN-36	Glucosidase	Metabolism
	α-Glucosidase-IN-36（compound 5g）作为一种α-glucosidase抑制剂，表现出有效的抑制活性，其IC50值为6.69 ± 0.18 μM，Ki值为1.65 μM，Kis值为4.54 μM。该化合物通过与α-glucosidase的活性位点结合及可能改变其二级结构来执行其抑制功能。α-Glucosidase-IN-36在2型糖尿病（T2DM）的研究中有应用潜力。
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...

化合物

α-Glucosidase-IN-2

Cat.No: T61249

α-Amylase/α-Glucosidase-IN-2

Cat.No: T61706

α-Glucosidase-IN-22

Cat.No: T67898

Target: Glucosidase

α-Glucosidase-IN-33

Cat.No: T78864

Target: Glucosidase

α-Glucosidase-IN-34

Cat.No: T78865

Target: Glucosidase

α-Glucosidase-IN-27

Cat.No: T79237

Target: Glucosidase

α-Glucosidase-IN-26

Cat.No: T78731

Target: Glucosidase

α-Glucosidase-IN-30

Cat.No: T79318

Target: Glucosidase

α-Glucosidase-IN-36

Cat.No: T78881

Target: Glucosidase

Australine (hydrochloride)

Cat.No: T37843

Cat. No.	Product Name	Target	Signaling Pathways
TN1488	Chrysin 6-C-glucoside 8-C-arabinoside	Others	Others
	Chrysin 6-C-glucoside 8-C-arabinoside 是α±-葡萄糖苷酶抑制剂，α±-葡萄糖苷酶抑制剂广泛用于2型糖尿病的治疗。
TN1487	Chrysin 6-C-arabinoside 8-C-glucoside	Others	Others
	Chrysin 6-C-arabinoside 8-C-glucoside 是α±-葡萄糖苷酶抑制剂，α±-葡萄糖苷酶抑制剂广泛用于2型糖尿病的治疗。
T6S1371	Isovitexin Homovitexin,Saponaretin,Apigenin-6-C-Glucoside,异牡荆黄素	NF-κB; JNK; Glucosidase	MAPK; Metabolism; NF-κB
	Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮，具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似，抑制NF-κB 的活化。
T5690	7,4'-Di-O-methylapigenin 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE	Amylase	Metabolism
	7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) 可能具有抗真菌c.zeyheri 的作用，是一种潜在的抗真菌药物。它还能抑制药物流出泵(IC50 = 51.64μg /毫升)。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
TN4279	Isoderrone	Tyrosinase	Proteases/Proteasome
	Isoderrone 在体外对α-葡萄糖苷酶(α-glucosidase)有抑制作用；它是一种蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂，IC50值为22.7±1.7μM，表明它可能是一种治疗2型糖尿病的新药。
T75477	Epicoccone B
	Epicoccone B 首次报道于C.globosum，具有清除 DPPH 自由基的能力，IC50值为10.8 μM，并具有有效的 α-葡萄糖苷酶抑制作用，IC50值为 27.3 μM。具有抗HIV 活性。
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Chrysin 6-C-glucoside 8-C-arabinoside

Cat.No: TN1488

Target: Others

Chrysin 6-C-arabinoside 8-C-glucoside

Cat.No: TN1487

Target: Others

Cat.No: T6S1371

Synonym: Homovitexin,Saponaretin,Apigenin-6-C-Glucoside,异牡荆黄素

Target: NF-κB, JNK, Glucosidase

7,4'-Di-O-methylapigenin

Cat.No: T5690

Synonym: 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE

Target: Amylase

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Cat.No: TN4279

Target: Tyrosinase

Cat.No: T75477

Cat.No: T38330

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