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IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)

产品编号 TMPY-02818
别名: 白细胞介素, FIL1, 白介素, interleukin 36, α, IL36A, IL1(EPSILON), IL1(ε), FIL1E, FIL, interleukin 36, alpha, IL1F6, IL-1F6, FIL1(EPSILON), IL1E, FIL1(ε), 1E, IL36 α/IL-1F6

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.2 kDa and the accession number is Q9UHA7.

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IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
20 μg ¥ 1,950 5日内发货
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产品目录号及名称: IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) (TMPY-02818)
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生物活性 Testing in progress
产品描述 IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.2 kDa and the accession number is Q9UHA7.
种属 Human
表达系统 E. coli
标签 N-His
蛋白编号 Q9UHA7
别名 白细胞介素, FIL1, 白介素, interleukin 36, α, IL36A, IL1(EPSILON), IL1(ε), FIL1E, FIL, interleukin 36, alpha, IL1F6, IL-1F6, FIL1(EPSILON), IL1E, FIL1(ε), 1E, IL36 α/IL-1F6
蛋白构建 mature form of Human IL1F6 (Q9UHA7) (Lys 6-Phe158)
蛋白纯度 > 99 % as determined by SDS-PAGE
分子量 19.2 kDa (predicted)
内毒素 Please contact us for more information.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

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Keywords

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) 白细胞介素 FIL1 白介素 interleukin 36, α IL36A FIL-1 IL1(EPSILON) IL1(ε) FIL1E FIL interleukin 36, alpha IL1F6 IL-1F6 FIL 1 FIL1(EPSILON) IL1E FIL1(ε) 1E IL36 α/IL-1F6 recombinant recombinant-proteins proteins protein

 

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