GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q99988.

规格	价格/CNY		数量
100 μg	￥ 6,670	5日内发货
500 μg	￥ 26,700	5日内发货
1 mg	￥ 44,500	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 6,670

5日内发货

500 μg

￥ 26,700

5日内发货

1 mg

￥ 44,500

5日内发货

生物活性

Immobilized Human GFRAL, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Human GDF15, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.

产品描述

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	Q99988
别名	MIC-1, PTGFBPTGF-β, GDF15, PTGF-β, GDF-15, PTGF-beta, Placental TGF-beta, PTGFBPTGF-beta, NAG-1, RG-1, Placental TGF-β, PDF, PLAB, PTGFB, MIC1
蛋白构建	Ala197-Ile308
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	37.9 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

内毒素	< 1 EU/μg by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.