Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tebipenem Pivoxil (Orapenem) 是一种碳青霉烯类新型口服抗生素。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 291 | 现货 | ||
2 mg | ¥ 369 | 现货 | ||
5 mg | ¥ 496 | 现货 | ||
10 mg | ¥ 787 | 现货 | ||
25 mg | ¥ 1,280 | 现货 | ||
50 mg | ¥ 1,860 | 现货 | ||
100 mg | ¥ 2,980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 546 | 现货 |
产品描述 | Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections. |
体外活性 | Tebipenem Pivoxil has high?intestinal apical membrane permeability due to plural intestinal transport routes, including the uptake transporters such as OATP1A2 and OATP2B1 as well as simple diffusion. [1] Tebipenem Pivoxil is quickly converted to tebipenem?(TBPM), an active form of?Tebipenem Pivoxil. Tebipenem Pivoxil are absorbed quickly, and the bioavailability is 71.4%, 59.1%, 34.8% and 44.9%, respectively, in mouse, rat, dog and monkey. [2] Tebipenem shows the strongest bactericidal activity as early as 2 h after exposure at two times the MIC. Tebipenem shows higher affinities for PBP 1A and PBP 2B, high-molecular-weight enzymes, and for PBP 3, a low-molecular-weight enzyme, than for PBP 2X.?[3] Tebipenem?has a potent?activity?against?Neisseria gonorrhoeae; its?activity?is comparable to it of cefixime that has most potent activity among oral antibiotics. [4] |
体内活性 | Tebipenem Pivoxil results in survival rate of 83%, compared with 25% survival for Amoxicillin and 0% survival for controls in animal model of?otitis?media. [5] Tebipenem?exhibits?slow?tight-binding inhibition at low micromolar concentrations versus the chromogenic?substrate?nitrocefin.?Tebipenem?acyl-enzyme complex remains stable for greater than 90 min and exists as mixture of the covalently bound drug and the bound retro-aldol cleavage product. [6] |
别名 | ME1211, Orapenem, 替比培南匹酯 |
分子量 | 497.63 |
分子式 | C22H31N3O6S2 |
CAS No. | 161715-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 81 mg/mL (162.8 mM)
DMSO: 92 mg/mL (184.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.0095 mL | 10.0476 mL | 20.0953 mL | 50.2381 mL |
5 mM | 0.4019 mL | 2.0095 mL | 4.0191 mL | 10.0476 mL | |
10 mM | 0.201 mL | 1.0048 mL | 2.0095 mL | 5.0238 mL | |
20 mM | 0.1005 mL | 0.5024 mL | 1.0048 mL | 2.5119 mL | |
50 mM | 0.0402 mL | 0.201 mL | 0.4019 mL | 1.0048 mL | |
100 mM | 0.0201 mL | 0.1005 mL | 0.201 mL | 0.5024 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tebipenem Pivoxil 161715-24-8 Microbiology/Virology Antibiotic Antibacterial broad antibacterial spectrum L 084 penicillin-binding protein inhibit L-084 Inhibitor orally active ME-1211 Haemophilus influenza L084 Bacterial Erythromycin-resistant Streptococcus pneumonia Streptococcus pneumonia ME1211 ME 1211 Orapenem 替比培南匹酯 inhibitor