Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sodium Picosulfate (Laxoberal) 可以抑制水和电解质的吸收,促进它们的分泌。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 187 | 现货 | ||
25 mg | ¥ 315 | 现货 | ||
50 mg | ¥ 587 | 现货 | ||
100 mg | ¥ 967 | 现货 | ||
200 mg | ¥ 1,430 | 现货 | ||
500 mg | ¥ 2,420 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 259 | 现货 |
产品描述 | Sodium Picosulfate (Laxoberal) inhibits absorption of water and electrolytes, and increases their secretion. |
体外活性 | Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1] |
体内活性 | Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4] |
别名 | Evacuol, Picolax, 匹克硫酸钠, Sodium Picosulphate, 匹可硫酸钠, Laxoberal |
分子量 | 481.41 |
分子式 | C18H15NO8S2·2Na |
CAS No. | 10040-45-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 3 mg/mL (6.23 mM)
H2O: 88 mg/mL (182.8 mM)
DMSO: 50 mg/mL (103.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / H2O / DMSO | 1 mM | 2.0772 mL | 10.3862 mL | 20.7723 mL | 51.9308 mL |
5 mM | 0.4154 mL | 2.0772 mL | 4.1545 mL | 10.3862 mL | |
H2O / DMSO | 10 mM | 0.2077 mL | 1.0386 mL | 2.0772 mL | 5.1931 mL |
20 mM | 0.1039 mL | 0.5193 mL | 1.0386 mL | 2.5965 mL | |
50 mM | 0.0415 mL | 0.2077 mL | 0.4154 mL | 1.0386 mL | |
100 mM | 0.0208 mL | 0.1039 mL | 0.2077 mL | 0.5193 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sodium Picosulfate 10040-45-6 Others inhibit Inhibitor Evacuol Picolax 匹克硫酸钠 Sodium Picosulphate 匹可硫酸钠 Laxoberal inhibitor