keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) 是一种三肽,可刺激促甲状腺素和催乳素的释放。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 193 | 现货 | ||
5 mg | ¥ 417 | 现货 | ||
10 mg | ¥ 598 | 现货 | ||
25 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 3,430 | 现货 | ||
200 mg | ¥ 4,980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 511 | 现货 |
产品描述 | Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin. |
体内活性 | Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin |
动物实验 | Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted. |
别名 | Thyroliberin Acetate, TRF Acetate, Synthetic thyrotropin-releasing hormone Acetate, Lopremone Acetate, pGlu-His-Pro-NH2 Acetate, TRH Acetate |
分子量 | 422.44 |
分子式 | C18H26N6O6 |
CAS No. | T6956L |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (65.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3672 mL | 11.836 mL | 23.672 mL | 59.18 mL |
5 mM | 0.4734 mL | 2.3672 mL | 4.7344 mL | 11.836 mL | |
10 mM | 0.2367 mL | 1.1836 mL | 2.3672 mL | 5.918 mL | |
20 mM | 0.1184 mL | 0.5918 mL | 1.1836 mL | 2.959 mL | |
50 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 1.1836 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Protirelin Acetate(24305-27-9 free base) T6956L Endocrinology/Hormones Thyroid hormone receptor(THR) Protirelin Acetate(24305279 free base) Thyroliberin Acetate TRF Acetate Synthetic thyrotropin-releasing hormone Acetate Lopremone Acetate pGlu-His-Pro-NH2 Acetate TRH Acetate Protirelin Acetate(24305 27 9 free base) Inhibitor inhibitor inhibit