Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cephradine (Anspor) 是广谱口服活性头孢菌素。它对革兰氏阳性和革兰氏阴性病原体都有活性。它已用于泌尿生殖系统、胃肠道和呼吸道感染以及皮肤和软组织感染的研究。它通过直接抑制TOPK 抑制太阳紫外线诱导的皮肤炎症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 132 | 现货 | ||
50 mg | ¥ 178 | 现货 | ||
100 mg | ¥ 247 | 现货 | ||
200 mg | ¥ 363 | 现货 | ||
500 mg | ¥ 619 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 150 | 现货 |
产品描述 | Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. |
体内活性 | Cephradine 的急性、亚急性和慢性口服毒性以及急性和亚急性肠外毒性较低。每天给猴子静脉注射Cephradine 2 周后,这些动物没有出现肾毒性症状。Cephradine 不会对小鼠或大鼠的后代产生任何致畸变化。Cephradine 这种单一的头孢菌素抗生素既可用于口服制剂,也可用于肠外制剂,这是一种明显的治疗优势[2]。 |
细胞实验 | Cells Are seeded in six-well culture plates (9.6 cm2, growth area) at a density of 105 cells/cm2. At 2 days postseeding, the medium is removed and cells are washed twice with pH 6.0 uptake buffer. Independent studies are performed for each drug solution at 1 mg/mL made in pH 6.0 uptake buffer. At each time point (10, 20, 30, 45, 60, 90 min), drug solution is removed and cells are washed three times with ice-cold pH 6.0 uptake buffer. One milliliter of Milli-Q water is added to each well and incubated for 30 min at 25 °C. Cells are harvested and sonicated for 1-2 min. ZnSO4 solution (8%, 200 mL) is added to the cell lysate, vortexed rigorously, and centrifuged for 5 min at 3000 rpm. After filtration of the supernatant through a membrane filter (0.45 mm), samples are analyzed by HPLC. (Only for Reference) |
别名 | Anspor, Cephradin, Velosef, SQ-11436, Sefril, 头孢拉定 |
分子量 | 349.4 |
分子式 | C16H19N3O4S |
CAS No. | 38821-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 8.33 mg/mL (23.84 mM), Sonication is recommended.
DMSO: 3.6 mg/mL (10.30 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.862 mL | 14.3102 mL | 28.6205 mL | 71.5512 mL |
5 mM | 0.5724 mL | 2.862 mL | 5.7241 mL | 14.3102 mL | |
10 mM | 0.2862 mL | 1.431 mL | 2.862 mL | 7.1551 mL | |
H2O | 20 mM | 0.1431 mL | 0.7155 mL | 1.431 mL | 3.5776 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cephradine 38821-53-3 MAPK Microbiology/Virology Antibiotic Antibacterial TOPK Gram-negative Grampositive Anspor Cephradin Velosef Oral SQ11436 Genitourinary Gastrointestinal Bacterial SQ-11436 Sefril Infections Inhibitor SQ 11436 inhibit Cefradine 头孢拉定 inhibitor