Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH6953755 是一种具有口服活性、高效性和选择性的 YES1 激酶抑制剂(IC50:1.8 nM)。CH6953755 具有抗癌活性,通过抑制 YES1 激酶来抑制癌细胞增殖。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 4,990 | 现货 | ||
10 mg | ¥ 7,890 | 现货 | ||
25 mg | ¥ 10,600 | 现货 | ||
50 mg | ¥ 15,800 | 现货 | ||
100 mg | ¥ 21,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 5,490 | 现货 |
产品描述 | CH6953755 is an orally active, potent and selective YES1 kinase inhibitor (IC50:1.8 nM).CH6953755 has anticancer activity and inhibits cancer cell proliferation by inhibiting YES1 kinase. |
靶点活性 | YES1:1.8 nM |
体外活性 |
CH6953755 inhibits the growth of cancer cell lines with YES1 amplification in a concentration-dependent manner (0.001-1 μM; 4 days)[1]. Preventing autophosphorylation of YES1 at the Tyr426 site, CH6953755 (0.001-1 μM; 2 hours) upregulates enzymatic activity in KYSE70 cells carrying YES1 amplification[1].In KYSE70 and RERF-LC-AI cells with YES1 amplification, CH6953755 (0.1, 0.3, 1, 3 μM) inhibits TEAD luciferase reporter gene activity[1]. |
体内活性 |
CH6953755 exhibits selective antitumor activity in xenograft tumors following oral administration (60 mg/kg/day; 10 days), accompanied by inhibition of phosphorylation at Tyr426 of YES1[1]. In a dose-dependent manner, CH6953755 (oral; 7.5, 15, 30, 60 mg/kg) inhibits phosphorylation at Tyr426 of YES1[1]. |
分子量 | 552.55 |
分子式 | C26H22F2N6O4S |
CAS No. | 2055918-71-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (180.98 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8098 mL | 9.049 mL | 18.0979 mL | 45.2448 mL |
5 mM | 0.362 mL | 1.8098 mL | 3.6196 mL | 9.049 mL | |
10 mM | 0.181 mL | 0.9049 mL | 1.8098 mL | 4.5245 mL | |
20 mM | 0.0905 mL | 0.4524 mL | 0.9049 mL | 2.2622 mL | |
50 mM | 0.0362 mL | 0.181 mL | 0.362 mL | 0.9049 mL | |
100 mM | 0.0181 mL | 0.0905 mL | 0.181 mL | 0.4524 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CH6953755 2055918-71-1 Angiogenesis Tyrosine Kinase/Adaptors Src CH-6953755 CH 6953755 Inhibitor inhibitor inhibit