Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASP-2905 是一种有效且选择性的钾通道 Kv12.2抑制剂。ASP2905 (ASP-2905) 可以穿越血脑屏障并具有抗精神病活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 248 | 现货 | ||
2 mg | ¥ 368 | 现货 | ||
5 mg | ¥ 632 | 现货 | ||
10 mg | ¥ 995 | 现货 | ||
25 mg | ¥ 1,960 | 现货 | ||
50 mg | ¥ 3,190 | 现货 | ||
100 mg | ¥ 4,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 727 | 现货 |
产品描述 | ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities |
体外活性 | ASP2905 (0.1 M, 1 M) decreased the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons.?In mice, ASP2905 reversed the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine (minimum effective dose of ASP2905: 0.0625mg/kg, po).?ASP2905 ameliorated the cognitive deficits of aged rats in step-through passive avoidance (0.0313 and 0.0625mg/kg, po) and Morris water-maze tasks (0.01mg/kg, po) and effectively penetrated the brain.?The mean plasma and brain concentrations of ASP2905 reached their maxima (Cmax = 0.399ng/ml and 1.77ng/g, respectively) 1h after a single oral administration and then decreased (t1/2 = 1.5-1.6h) (brain plasma ratio = 2.7-4.9).?ASP2905 is a selective, orally administered inhibitor of KCNH3, which can enhance cognitive performance[1]. |
体内活性 | ASP2905 on channel activity in vitro and its neuropharmacological properties in young and aged rats as well as in mice.?ASP2905 potently inhibited potassium currents in CHO cells expressing KCNH3 (IC50 = 9.0nM).?In contrast, ASP2905 ( 10μM) minimally bound with low affinities to 55 transmembrane proteins.[1] |
别名 | ASP-2905 |
分子量 | 388.4 |
分子式 | C20H17FN8 |
CAS No. | 792184-90-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (70.8 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5747 mL | 12.8733 mL | 25.7467 mL | 64.3666 mL |
5 mM | 0.5149 mL | 2.5747 mL | 5.1493 mL | 12.8733 mL | |
10 mM | 0.2575 mL | 1.2873 mL | 2.5747 mL | 6.4367 mL | |
20 mM | 0.1287 mL | 0.6437 mL | 1.2873 mL | 3.2183 mL | |
50 mM | 0.0515 mL | 0.2575 mL | 0.5149 mL | 1.2873 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ASP2905 792184-90-8 Membrane transporter/Ion channel Potassium Channel Kv12.2 KcsA Inhibitor ASP 2905 cognitive Kcnh3 CNS inhibit ASP-2905 antipsychotic inhibitor