Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Equol ((+)-Equol) 是一种 ERα (Ki:27.4 nM) 和 Erβ (Ki:15.4 nM) 激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 273 | 现货 | ||
2 mg | ¥ 389 | 现货 | ||
5 mg | ¥ 593 | 现货 | ||
10 mg | ¥ 996 | 现货 | ||
25 mg | ¥ 1,890 | 现货 | ||
50 mg | ¥ 2,790 | 现货 | ||
100 mg | ¥ 3,970 | 现货 | ||
200 mg | ¥ 5,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 683 | 现货 |
产品描述 | (R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively. |
靶点活性 | ERβ:15.4 nM (Ki), ERα:27.4 nM (Ki) |
体外活性 | (R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2]. |
体内活性 | In Animals, (R)-Equol has a significantly reduced number of palpable tumors over time when compared with Controls (P=0.002).In addition, the number of palpable tumors formed by each rat in the (R)-Equol fed group was significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animals is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003) [3]. |
别名 | (+)-Equol, R-雌马酚 |
分子量 | 242.27 |
分子式 | C15H14O3 |
CAS No. | 221054-79-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (412.76 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.1276 mL | 20.6381 mL | 41.2763 mL | 103.1907 mL |
5 mM | 0.8255 mL | 4.1276 mL | 8.2553 mL | 20.6381 mL | |
10 mM | 0.4128 mL | 2.0638 mL | 4.1276 mL | 10.3191 mL | |
20 mM | 0.2064 mL | 1.0319 mL | 2.0638 mL | 5.1595 mL | |
50 mM | 0.0826 mL | 0.4128 mL | 0.8255 mL | 2.0638 mL | |
100 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 1.0319 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(R)-Equol 221054-79-1 Endocrinology/Hormones Estrogen/progestogen Receptor (+)-Equol (R) Equol Equol (R)Equol Inhibitor Estrogen Receptor/ERR R-雌马酚 inhibit inhibitor