ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product Name	CAS No.	Purity
TN2641	15-Methoxypinusolidic acid 化合物 TN2641	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN5153	Torilin 窃衣素	13018-10-5	98%
TN5153	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF...
TN4271	Isochamaejasmine 异狼毒素	93859-63-3	98%
TN4271	Isochamaejasmine 分离自 S. chamaejasme L. 中分离出来，可抑制 NF-κB 活化。 Isochamaejasmine 通过抑制 Bcl-2 家族蛋白的活性诱导白血病细胞凋亡，可用于抗癌研究。
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3541	Broussonin E 化合物 TN3541	90902-21-9	98%
TN3541	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
TN4107	Ganoderic acid X 化合物 TN4107	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN3655	Cimiside E 化合物 TN3655	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
TN3486	Bakkenolide IIIa 化合物 TN3486	915289-60-0	98%
TN3486	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB...
TN2118	Lup-20(29)-en-28-oic acid 白头翁皂苷D	848784-85-0	98%
TN2118	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
TN3806	Dehydroglyasperin C 化合物 TN3806	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
T11201	Enniatin A1 恩镰孢菌素 A1	4530-21-6	98%
T11201	Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 4...
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮	32884-36-9	98%
TN1462	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
T6S0525	Farrerol 杜鹃素	24211-30-1	99.96%
T6S0525	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T2P2806	Hederacolchiside A1 革叶常春藤皂苷 A1	106577-39-3	99.92%
T2P2806	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
TN2165	Rubrofusarin gentiobioside 芸苔红素龙胆苷	24577-90-0	99.91%
TN2165	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) 一种分离自决明子的、具有清除自由基作用的化合物。
T6S0619	Pachymic acid 茯苓酸	29070-92-6	99.91%
T6S0619	Pachymic acid (3-O-Acetyltumulosic acid) 是来自茯苓的一种三萜，可抑制Akt 和ERK 信号传导途径。
T3876	Loureirin B 龙血素 B	119425-90-0	99.91%
T3876	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
TCS2170	2,5-Dihydroxyacetophenone 2 '，5'-二羟基苯乙酮	490-78-8	99.91%
TCS2170	2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1/2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。
T22996	ML-191 化合物ML-191	931695-79-3	99.91%
T22996	ML-191 是GPR55的拮抗剂。它可以阻断溶血磷脂酰肌醇诱导的 GPR55 信号传导，在过表达 GPR55 的 U2OS 细胞中EC50=1.076 µM；它抑制 LPI 诱导ERK1/2 磷酸化的IC50=328 nM。当浓度为达到30 µM 时，可抑制 PKCβII 的受体依赖性易位。
T4082	Astragaloside 黄芪甲苷	17429-69-5	99.9%
T4082	Astragaloside 是黄芪中的主要活性成分之一。