ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product Name	CAS No.	Purity
TN5100	Taspine 化合物 TN5100	602-07-3	98%
TN5100	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN3397	Alpinumisoflavone 化合物 TN3397	34086-50-5	98%
TN3397	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T12409	PERK-IN-2 化合物 T12409	1337531-83-5	98%
T12409	PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
TN1793	Isorhamnetin 3-O-galactoside 异鼠李素-3-O-半乳糖苷	6743-92-6	98%
TN1793	Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN4489	Manassantin A 化合物 TN4489	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN3539	Broussonin A 化合物 TN3539	73731-87-0	98%
TN3539	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3839	Desoxo-narchinol A 化合物 TN3839	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN2995	4,10-Aromadendranediol 化合物 TN2995	70051-38-6	98%
TN2995	4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 6,4'-二羟基-7-甲氧基二氢黄酮	189689-32-5	98%
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物，具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的...
TN3152	6-Acetonyldihydrochelerythrine 化合物 TN3152	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN4490	Manassantin B 化合物 TN4490	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
T16998	Tauroursodeoxycholate dihydrate 牛磺熊去氧胆酸二水合物	117609-50-4	98%
T16998	Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
TN4213	Hirsutenone 化合物 TN4213	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 化合物 TN3931	57719-81-0	98%
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
T13680	Enniatin B1 恩镰孢菌素 B1	19914-20-6	98%
T13680	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation...
T12410	PERK-IN-3 化合物 T12410	1337532-08-7	98%
T12410	PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
T23337	SCH772984 HCl 化合物SCH772984 HCl	T23337	98%
T23337	SCH772984 HCl 是一种特异性的 ERK1/2 抑制剂，具有 I 型和 II 型激酶抑制剂的特性，其 IC50 分别为 4 和 1 nM。 SCH772984 HCl 在 BRAF、NRAS 或 KRAS 突变的肿瘤细胞中具有纳摩尔级细胞效力，并诱导肿瘤消退。 SCH772984 HCl 可用于 MAPK 抑制...
T36067	Bongkrekic acid 米酵菌酸	11076-19-0	98%
T36067	Bongkrekic acid (Bongkrekic Acid (ammonium salt)) 是一种由伯克霍尔德菌（Burkholderia gladioli）分泌的线粒体毒素，抑制腺嘌呤核苷酸转位酶（ANT）。Bongkrekic acid Bongkrekic acid 通过 p38、ERK、PAD4 和 P...
TN5387	Grasshopper ketone 蚱蜢酮	41703-38-2	98%
TN5387	Grasshopper ketone 是从褐藻马尾藻中分离的化合物，是 RAW 264.7 细胞中 LPS 诱导的 NO 产生的有效抑制剂，通过抑制 MAPK（ERK，JNK 和 p38）和 NF-κB p65磷酸化来诱导抗炎作用。
TN3003	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol 化合物 TN3003	69768-97-4	98%
TN3003	(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...