ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product Name	CAS No.	Purity
T16390	Omtriptolide 昂曲托来	195883-06-8	98%
T16390	Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN1889	Lupalbigenin 化合物Lupalbigenin	76754-24-0	98%
TN1889	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1062	Peonidin chloride 氯化芍药素	134-01-0	98%
TN1062	Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast c...
TN3139	5α-Hydroxycostic acid 化合物 TN3139	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN1751	Hydroxycitric acid 2-羟基柠檬酸	6205-14-7	98%
TN1751	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1775	Isocryptotanshinone 异隐丹参酮	22550-15-8	98%
TN1775	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
T15377	Ravoxertinib hydrochloride 化合物 T15377	2070009-58-2	98%
T15377	Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN2328	Zeylenone 山椒子烯酮	193410-84-3	98%
TN2328	Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物，具有抗肿瘤和抗癌细胞增殖活性，通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖，诱导细胞凋亡 (apoptosis)。
T10299	AMG PERK 44 化合物 T10299	1883548-84-2	98%
T10299	AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 ...
T13679	Enniatin B 恩镰孢菌素 B	917-13-5	98%
T13679	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activ...
TN4683	Nyasol 化合物 TN4683	96895-25-9	98%
TN4683	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN1211	2-Hydroxy-3-methylanthraquinone 化合物2-Hydroxy-3-methylanthraquinone	17241-40-6	98%
TN1211	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
T11228	ERK2 IN-1 化合物 T11228	1093061-47-2	98%
T11228	ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
TN4166	Griffipavixanthone 化合物 TN4166	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN3711	Corylifol C 化合物 TN3711	775351-91-2	98%
TN3711	Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
TN4179	Haginin A 化合物 TN4179	74174-29-1	98%
TN4179	Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activ...
TL0014	Pinusolide 化合物 TL0014	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...