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9

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9725	GSK-3β inhibitor 10	Others	Others
	GSK-3β inhibitor 10 具有美白、抗氧化和 PPAR 活性。
TP2487	Oligopeptide-68 Acetate Oligopeptide-68 Acetate(1206525-47-4 Free base),醋酸寡肽-68	Others	Others
	Oligopeptide-68 Acetate 是一种多肽。它是一种新型美白原料，它模拟 TGF-β和细胞表面的受体结合，通过抑制 MITF 分子内通道达到降低诱发型和遗传性色素沉积，以实现美白亮肤的功效。
T8856	Ascorbyl Propyl Hyaluronate	Others	Others
	Ascorbyl Propyl Hyaluronate 是透明质酸和维生素 C 的完美结合，克服了维生素 C 的不稳定性，是改善皱纹、滋润、镇静肌肤、美白的优质原料。
T60278	Tyrosinase-IN-2	Tyrosinase	Proteases/Proteasome
	Tyrosinase-IN-2 (compound 67) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种含铜金属酶，负责黑色素生物合成和酶促褐变中的限速催化步骤。Tyrosinase-IN-2 具有研究皮肤美白剂和食品防腐剂的潜力。
T33628	Neoagarobiose Agarobiose
	Neoagarobiose has a whitening effect as a novel moisturizer.
T71887	Hydroquinone monobenzoate
	Hydroquinone monobenzoate is an oxidoreductant and potential topoisomerase II inhibitor commercially used in skin whitening treatments and photography development. It may induce DNA damage.
T61460	Tyrosinase-IN-3
	Tyrosinase-IN-3 (compound 54) is a powerful tyrosinase inhibitor, an enzyme involved in the key catalytic step of melanin biosynthesis and enzymatic browning. As a copper-containing metalloenzyme, tyrosinase plays a crucial role in these processes. The compound shows promise for studying skin whitening agents and food preservatives [1].
T60484	Tyrosinase-IN-4
	Tyrosinase-IN-4 (compound 34) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种有前途的靶点，酪氨酸酶抑制剂可用作皮肤美白剂和食品防腐剂。 Tyrosinase-IN-4 在食品、化妆品、农业和医药等领域具有应用潜力[1]。
T60449	Tyrosinase-IN-1
	Tyrosinase-IN-1 (compound 90) 是有效的酪氨酸酶抑制剂。酪氨酸酶是一个很前途的靶点，酪氨酸酶抑制剂可用作美白剂和食品防腐剂，因此在食品、化妆品、农业和医药等领域具有广阔的应用前景。

化合物

GSK-3β inhibitor 10

Cat.No: T9725

Target: Others

Oligopeptide-68 Acetate

Cat.No: TP2487

Synonym: Oligopeptide-68 Acetate(1206525-47-4 Free base),醋酸寡肽-68

Target: Others

Ascorbyl Propyl Hyaluronate

Cat.No: T8856

Target: Others

Tyrosinase-IN-2

Cat.No: T60278

Target: Tyrosinase

Cat.No: T33628

Synonym: Agarobiose

Hydroquinone monobenzoate

Cat.No: T71887

Tyrosinase-IN-3

Cat.No: T61460

Tyrosinase-IN-4

Cat.No: T60484

Tyrosinase-IN-1

Cat.No: T60449

Cat. No.	Product Name	Target	Signaling Pathways
T3745	3,4-Dimethoxyphenol 4-Hydroxyveratrole,3,4-二甲氧基苯酚,3,4-dimethoxyphel	Tyrosinase	Proteases/Proteasome
	3,4-Dimethoxyphenol (4-Hydroxyveratrole) 是一种植物来源的苯基丙烷化合物，可在化妆品中用作增白剂。它可从细菌发酵液中分离出，有抗氧化作用。它具有酪氨酸酶抑制活性。
T19924	Rhododendrol Betuligenol,Frambinol,杜鹃醇	Others	Others
	Rhododendrol (Frambinol) 是一种黑色素合成物，防止雄性小鼠高脂饮食引起的体重升高和增加雄性小鼠白色脂肪细胞的脂肪分解。Rhododendrol 可用作美白/美白化妆品抑制剂。
T6000	Delta-Tocopherol (+)-DELTA-生育酚,D-DELTA-TOCOPHEROL	Endogenous Metabolite	Metabolism
	Delta-Tocopherol 是维生素 E 的异构体，具有抗氧化活性。
TQ0118	Britannilactone Desacetylinulicin	Others	Others
	Britannilactone (Desacetylinulicin) 是来自 Inula britannica 的倍半萜烯，具有抗炎抗肿瘤活性。Britannilactone 与这种抗黑色素活性有关，可用于研究皮肤美白。
T7966	3-O-Ethyl-L-ascorbic acid	Tyrosinase	Proteases/Proteasome
	3-O-Ethyl-L-ascorbic acid 是一种具有增白能力的化妆品酪氨酸酶 (tyrosinase) 抑制剂，是一种稳定的维生素 C 衍生物。它还具有抗氧化能力。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
TN2296	Vinaginsenoside R4 越南参皂苷R4	Others	Others
	Vinaginsenoside R4 是分离自水培人参的叶子中。它能够抑制黑色素的生物合成，并增强斑马鱼的色素沉着，对 melan-a 细胞没有任何细胞毒性作用。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
T4S0998	Trifolirhizin 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷	TNF; Tyrosinase	Apoptosis; Proteases/Proteasome
	Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性，IC50=506 μM。它具有抗炎和抗癌的潜能。
TN2026	Oxyresveratrol 3'-O-β-D-glucopyranoside Oxyresveratrol 3'-O-beta-D-glucopyranoside,氧化白藜芦醇-3'-O-Β-D-吡喃葡萄糖苷	Tyrosinase	Proteases/Proteasome
	Oxyresveratrol-3'-O-beta-D-glucopyranoside shows tyrosinase inhibitory activity, it may be a potential candidate as skin-whitening agents without posing any serious side effects.
TN1320	6-O-Caffeoylarbutin	Others	Others
	6'-O-caffeoylarbutin may serve as a skin-whitening ingredient with the merits of potent melanin inhibition,less toxicity and reversible melanin synthesis after stopping use.
TN1840	Kurarinol	Tyrosinase; HBV; STAT	JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN3723	Cryptomeridiol	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.
TN4148	Glyasperin C	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant
TN1958	Mulberroside F 桑皮苷F,桑皮苷 F	Tyrosinase	Proteases/Proteasome
	Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be us

天然产物

3,4-Dimethoxyphenol

Cat.No: T3745

Synonym: 4-Hydroxyveratrole,3,4-二甲氧基苯酚,3,4-dimethoxyphel

Target: Tyrosinase

Cat.No: T19924

Synonym: Betuligenol,Frambinol,杜鹃醇

Target: Others

Delta-Tocopherol

Cat.No: T6000

Synonym: (+)-DELTA-生育酚,D-DELTA-TOCOPHEROL

Target: Endogenous Metabolite

Britannilactone

Cat.No: TQ0118

Synonym: Desacetylinulicin

Target: Others

3-O-Ethyl-L-ascorbic acid

Cat.No: T7966

Target: Tyrosinase

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Vinaginsenoside R4

Cat.No: TN2296

Synonym: 越南参皂苷R4

Target: Others

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Cat.No: T4S0998

Synonym: 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷

Target: TNF, Tyrosinase

Oxyresveratrol 3'-O-β-D-glucopyranoside

Cat.No: TN2026

Synonym: Oxyresveratrol 3'-O-beta-D-glucopyranoside,氧化白藜芦醇-3'-O-Β-D-吡喃葡萄糖苷

Target: Tyrosinase

6-O-Caffeoylarbutin

Cat.No: TN1320

Target: Others

Cat.No: TN1840

Target: Tyrosinase, HBV, STAT

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN3723

Target: PAFR, Antifection

Cat.No: TN4148

Target: Tyrosinase, Antifection

Cat.No: TN1958

Synonym: 桑皮苷F,桑皮苷 F

Target: Tyrosinase

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