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Search Results for " water solubility "

25

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24493	Monoelaidin
	Monoelaidin is a poorly water-soluble drug enhancer of solubility and oral bioavailability.
T6538	Hydroxypropyl Cellulose	Others	Others
	Hydroxypropyl Cellulose 是纤维素的衍生物，兼具水溶性和有机溶解性，用作食品添加剂和 DNA 分离的筛分基质。
T50013	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid	Others	Others
	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid 是一种合成化合物，具有强大的抗肿瘤活性，对肿瘤细胞有高效性和选择性，但其在水中的溶解性差且在高浓度下有潜在毒性。
T4545	Propacetamol Hydrochloride 盐酸丙帕他莫,Propacetamol HCL	Others	Others
	Propacetamol Hydrochloride (Propacetamol HCL) 是 paracetamol(acetaminophen) 的前药，具有改善的水溶性。当口服非甾体抗炎药不合适或矛盾时，丙帕西莫是一种静脉给药的镇痛药。
T14050	5-FAM 5-羧基荧光素,5-Carboxyfluorescein	Others	Others
	5-FAM (5-Carboxyfluorescein) 是一种绿色荧光探针(Ex/Em 为 490 nm/520 nm)，可用于肽，蛋白质和核苷酸的标记。
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T33606	NBI-30545
	NBI-30545 is a potent corticotropin-releasing factor-1 antagonist with sufficient lipophilicity and water solubility for the treatment of stress disorders.
T80936	Trisulfo-Cy3-acid disodium
	Trisulfo-Cy3-acid disodium, 作为一种Cy3（Cyanine3）染料衍生物，具备三个磺酸根离子（sulfonate），从而提供了优化的水溶性特征。
T19167	8pyDTZ	Others	Others
	8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission and improved water solubility. It can be used for in vivo luminescence imaging.
T69608	TG11-77 HCl
	TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T69609	TG11-77 free base
	TG11-77 free base is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 free base has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 free base are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T30538	BMS-695735 CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888
	BMS-695735, a benzimidazole inhibitor of insulin-like growth factor-1 receptor, has broad-spectrum antitumor activity in vivo. It was found that BMS-695735 had strong inhibition of CYP3A4, induction of CYP3A4 mediated by PXR transactivation, poor water so
T81067	Sulfo-Cy3(Me)COOH sodium
	Sulfo-Cy3(Me)COOH sodium 为含磺酸根离子的 Cy3（Cyanine3）染料衍生物，而 Trisulfo-Cy3-acid disodium 含 sulfonate （磺酸根离子），水溶性更佳。
T82852	BMI-Glu
	BMI-Glu，一种选择性γ-谷氨酰转肽酶(GGT)荧光探针，具有Km值为69.63 µM的高敏感性，以及优异的水溶性和生物相容性。
T18940	Cy2 CY2 Non-Sulfonated,Cyanine2	Others	Others
	Cy2 (CY2 Non-Sulfonated)是一种花青染料，波长长，吸收和发射可调，消光系数高，水溶性好。 Cy2 可用于标记寡核苷酸、肽和蛋白质中的氨基。
T63319	Antitubercular agent-32
	Antitubercular agent-32 是Benzothiazinone 衍生物，对结核分枝杆菌 M. tuberculosis 具有抑制作用，并表现出良好的代谢稳定性及水溶性。 Antitubercular agent-32 可以作用于 decaprenylphosphoryl-β-D-ribose 2'-氧化酶 (DprE1,IC50: 3.9 μM)，表现出抗结核效果。
T82866	Biotin-PEG-Biotin (MW 20000)
	Biotin-PEG-azide (MW 2000) 为含有生物素标记的聚乙二醇 (PEG) 衍生物。该生物素（Biotin）作为酶辅因子，在蛋白质标记应用中具有重要作用，而PEG是低毒性且具亲水性的水溶性聚合物。
T67948	OY-101
	OY-101为口服生效的特异性P-glycoprotein(P-gp)抑制剂。该化合物可增强耐药性肿瘤的敏感性，并有效逆转多药耐药现象。相较于Tetrandrine，OY-101在水溶性、细胞毒性以及逆转活性方面均表现出改进。
T71577	KOS-1584
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration,...
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T82868	Biotin-PEG-azide (MW 2000)
	Biotin-PEG-azide (MW 2000) 为生物素修饰的PEG衍生物，其中生物素用作蛋白质标记的酶辅因子，PEG为低毒性亲水聚合物。叠氮部分则作为离去基，可通过铜催化与炔烃发生反应，从而增强生物素对靶点的结合效率。
T31657	Epothilone F
	Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing
T74120	Cy5 maleimide
	Cy5 maleimide 是一种 CY 染料。CY 为花菁 (Cyanine) 的缩写，是由奇数个甲基单位连接的两个氮原子组成的化合物。菁类化合物具有波长长、吸收和发射可调、消光系数高、水溶性好、合成相对简单等特点。CY 系类染料常被用于蛋白，抗体以及小分子化合物的标记，对于蛋白抗体的标记，可以通过简单的混合反应来完成结合，以下我们介绍了蛋白抗体标记的标记方法，具有一定的参考意义。储存方式：避光。
T75337	Cy5.5-SE (DIPEA)
	Cy5.5-SE (Cyanine5.5 NHS ester) DIPEA 是一种以奇数个甲基单位连接两个氮原子的花菁(Cyanine)染料。该染料特点包括长波长、可调吸收发射、高消光系数、良好水溶性及合成相对简单。常用于蛋白、抗体和小分子化合物的标记，特别是蛋白抗体的标记，通过简单混合反应即可完成结合。储存应避光。
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Cat.No: T24493

Hydroxypropyl Cellulose

Cat.No: T6538

Target: Others

4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid

Cat.No: T50013

Target: Others

Propacetamol Hydrochloride

Cat.No: T4545

Synonym: 盐酸丙帕他莫,Propacetamol HCL

Target: Others

Cat.No: T14050

Synonym: 5-羧基荧光素,5-Carboxyfluorescein

Target: Others

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

Cat.No: T33606

Trisulfo-Cy3-acid disodium

Cat.No: T80936

Cat.No: T19167

Target: Others

Cat.No: T69608

TG11-77 free base

Cat.No: T69609

Cat.No: T30538

Synonym: CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888

Sulfo-Cy3(Me)COOH sodium

Cat.No: T81067

Cat.No: T82852

Cat.No: T18940

Synonym: CY2 Non-Sulfonated,Cyanine2

Target: Others

Antitubercular agent-32

Cat.No: T63319

Biotin-PEG-Biotin (MW 20000)

Cat.No: T82866

Cat.No: T67948

Cat.No: T71577

Cat.No: T68860

Biotin-PEG-azide (MW 2000)

Cat.No: T82868

Cat.No: T31657

Cat.No: T74120

Cy5.5-SE (DIPEA)

Cat.No: T75337

para-amino-Blebbistatin

Cat.No: T36400

Cat. No.	Product Name	Target	Signaling Pathways
T20597	Alginic acid Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine	Apoptosis; Autophagy; Histamine Receptor	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Alginic acid (Snow acid algin G) 是一种从褐海藻中提取的天然多糖，具有抗过敏和抗炎活性。 Alginic acid 抑制组胺释放，可用于食品工业。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
T81026	Tectorigenin sodium sulfonate
	Tectorigenin sodium sulfonate，一种经鸢尾黄素磺化并与饱和盐水混合得到的化合物，拥有高水溶性及优良抗氧化特性。
T82148	Hydrogenated soya phosphatidylcholines
	Hydrogenated soya phosphatidylcholines 是一种用于提升水溶性药物口服给药效果的天然产物，它能够增加药物负荷和溶解度，从而延长药物释放时间。
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。

天然产物

Cat.No: T20597

Synonym: Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine

Target: Apoptosis, Autophagy, Histamine Receptor

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated

Tectorigenin sodium sulfonate

Cat.No: T81026

Hydrogenated soya phosphatidylcholines

Cat.No: T82148

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

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