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Search Results for " virus fusion "

32

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T16276	NBD-556	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	NBD-556是一种 CD4 模拟物，识别 HIV-1 包膜蛋白 gp120 并诱导 gp120 重组，类似于 CD4 结合，可阻断 gp120-CD4 的相互作用。
TP2230	Fusion glycoprotein (92-106) [Human respiratory syncytial virus]	Others	Others
	Fusion glycoprotein (92-106) [Human respiratory syncytial virus] is a peptide with the sequence H2N-Glu-Leu-Gln-Leu-Leu-Met-Gln-Ser-Thr-Pro-Pro-Thr-Asn-Asn-Arg-OH, MW= 1741.96.
T0104	Umifenovir hydrochloride 盐酸阿比朵尔,Arbidol hydrochloride,Arbidol HCl,盐酸阿比多尔	SARS-CoV; Influenza Virus	Microbiology/Virology
	Umifenovir hydrochloride (Arbidol HCl) 是一种口服有效的广谱抗病毒药物，对多种包膜和非包膜病毒均有活性。它被用作抗流感病毒剂，可通过阻断病毒与宿主细胞膜的融合来抑制包膜病毒的细胞侵袭。它是一种 SARS-CoV-2 抑制剂，具有抗炎活性。
T13401	Ziresovir AK0529,RO-0529	RSV	Microbiology/Virology
	Ziresovir (RO-0529) 是一种呼吸道合胞病毒融合蛋白 (RSV F) 抑制剂，抑制 RSV 活性，可用于研究合胞病毒感。
T26914	BTA-9881 BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564	RSV	Microbiology/Virology
	BTA-9881 是一种具有口服活性的新型 RSV 融合抑制剂，具有抗病毒活性，可用于研究呼吸道合胞病毒感染。
T8793	CBS1117	Influenza Virus	Microbiology/Virology
	CBS1117 是一种病毒进入抑制剂，对甲型流感病毒 A/Puerto Rico/8/34 的 IC50为 70 nM。它干扰血凝素介导的融合过程。
T26914L	(R)-AZD 9639	Others	Others
	(R)-AZD 9639 是 AZD 9639 的 R型异构体。AZD 9639 是一种新型呼吸道合胞病毒（RSV）融合抑制剂，具有抗病毒活性。
T15621	Rilematovir JNJ-53718678,JNJ-678	EGFR; RSV	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Rilematovir (JNJ-678) 是一种融合蛋白抑制剂，具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
T30527	BMS-488043 CHEMBL238103,UNII-MKS21EJ435,BMS 043,BMS488043,BMS 488043	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS-488043 是一种新颖独特的口服小分子HIV融合抑制剂，可抑制人类免疫缺陷病毒 1 型（HIV-1）附着于 CD4（+）淋巴细胞。BMS-488043 可用于治疗免疫系统疾病、感染和泌尿生殖系统疾病，可用与研究HIV感染。
T17107	TMC353121	Others	Others
	TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).
T28604	RO5464466 RO 5464466,RO-5464466
	RO5464466 is an inhibitor of influenza A virus (H1N1) fusion.
T15625	JNJ4796	Others	Others
	JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).
T68413	CBS1194
	CBS1194 is a novel antiviral agent against influenza A virus (IAV), and is more specifically, a group 2 IAV fusion inhibitor. CBS1194 prevents membrane fusion of the virus through the inhibition of the conformational change of hemagglutinin (HA). CBS1194 causes steric hinderance that prevents the rearrangement of the HA that would normally be induced by low-pH, by fitting into the pocket by the fusion peptide.
T26848	BMS-433771 free base BMS-433771,BMS 433771,BMS433771
	BMS-433771, a novel inhibitor of respiratory syncytial virus (RSV), binds the RSV F glycoprotein and inhibits membrane fusion.
T27271	Enzaplatovir BTA-585,BTA 585,BTAC585,BTA585,BTA-C585
	Enzaplatovir is an inhibitor of Respiratory Syncytial Virus (RSV), can be used as a viral fusion protein inhibitor.
T28133	NB-64
	NB-64 is a HIV-1 entry inhibitor. NB-64 interferes the gp41 six-helix bundle formation and blocks virus fusion.
T68493	Umifenovir hydrochloride monohydrate
	Umifenovir hydrochloride monohydrate is an antiviral that inhibits membrane fusion by preventing contact between a virus and target host cells.
T13046	Syncytial Virus Inhibitor-1	Others	Others
	Syncytial Virus Inhibitor-1 is a potent and orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion(EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively).
T27983	MBX2546 MBX-2546,MBX 2546
	MBX2546 is an Influenza A Virus Fusion Inhibitor. MBX2546 binds to HA and inhibits HA-mediated membrane fusion. Both binding and stabilization of HA by MBX2546 are required for the inhibition of viral infection. Mutations in MBX2546-resistant influenza A/
T27668	JNJ-2408068 R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500
	JNJ-2408068 is an inhibitor of respiratory syncytial virus (RSV). JNJ-2408068 exhibited potent antiviral activity with EC50 of 2.1 nM. A similar inhibitory effect was observed in a RSV-mediated cell fusion assay (EC50= 0.9 nM). JNJ-2408068 interferes with
T40114	RSV-IN-2
	RSV-IN-2 is a powerful compound that acts as a dual inhibitor of both wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. It efficiently inhibits the activity of these proteins, with an EC50 value of 0.27 nM for the wild-type and 0.70 nM for the D486N-mutant protein.
T77094	Navivumab
	Navivumab (CT-P23)是针对甲型流感病毒(influenza A virus) HA血凝素的单克隆抗体。该药物通过结合HA2蛋白的茎融合结构域，能中和H1、H2、H5及H9型甲型流感病毒。
T79444	HA-IN-1	Influenza Virus	Microbiology/Virology
	HA-IN-1（compound 5g）是靶向血凝素（HA）胰蛋白酶切割位点的配体，表现出高亲和力。该化合物能够抑制HA介导的膜融合，并在体内有效降低肺部病毒滴度，展现其作为甲型流感病毒（IAV）抑制剂和抗流感药物的潜力。
T77158	Diridavumab
	Diridavumab为一种针对HA茎的单克隆抗体。它能稳定HA的融合前结构，阻断细胞膜与病毒膜在核内体内因pH变化引起的融合。此抗体主要用于H2流感病毒研究。
T7911	Arbidol
	Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-influenza virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的 SARS-CoV-2的抑制剂。
T75444	Peniterphenyl A
	Peniterphenyl A，一种源于深海青霉属植物的天然产物，能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用，干扰病毒的吸附和膜融合过程，进而有效阻断病毒感染。因此，Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。
T76292	Tifuvirtide
	Tifuvirtide (T-1249) 是一种肽类人类免疫缺陷病毒 1 型(HIV-1)融合抑制剂。Tifuvirtide 是一种合成设计的杂合逆转录病毒包膜多肽。Tifuvirtide 具有抗逆转录病毒活性。Tifuvirtide 可用于HIV 感染的研究。
T22800	Glycoprotein B (485-492)	Others	Others
	Glycoprotein B is a peptide with the sequence H2N-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH, MW= 922.04. glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus. The herpesvirus glycoprotein B is the most highly c
T63433	RSV-IN-5
	RSV-IN-5 是有效的野生型和突变呼吸道合胞病毒 (RSV) 融合蛋白的双重抑制剂。RSV-IN-5 能够作用于野生型 A2 F 蛋白及 D486N 突变 F 蛋白，他们的EC50值分别为2.0 nM、8.1 nM，表现出有效的抗 RSV 作用。
T77021	Gedivumab
	Gedivumab (MHAA4549A; RG7745)，一种高特异性人源单克隆抗体，靶向甲型流感病毒 (IAV)，通过与IAV血凝素蛋白的高度保守茎区结合，阻止其成熟并阻断核内体中的血凝素介导的膜融合，适用于IAV感染疾病研究。
T75102	COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
	COVID-19 Spike Protein mRNA 用于表达新型冠状病毒肺炎刺突蛋白，关键于 RNA 传递、翻译效率与细胞活力的检测。该蛋白定位于病毒膜表面，主导病毒与宿主细胞膜受体的结合及膜融合，促使 COVID-19 病毒入侵细胞。同时，它是宿主中和抗体作用的主要位点与疫苗开发的核心靶标。

化合物

Cat.No: T9231

Target: Antiviral

Cat.No: T16276

Target: HIV Protease

Fusion glycoprotein (92-106) [Human respiratory syncytial virus]

Cat.No: TP2230

Target: Others

Umifenovir hydrochloride

Cat.No: T0104

Synonym: 盐酸阿比朵尔,Arbidol hydrochloride,Arbidol HCl,盐酸阿比多尔

Target: SARS-CoV, Influenza Virus

Cat.No: T13401

Synonym: AK0529,RO-0529

Target: RSV

Cat.No: T26914

Synonym: BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564

Target: RSV

Cat.No: T8793

Target: Influenza Virus

Cat.No: T26914L

Target: Others

Cat.No: T15621

Synonym: JNJ-53718678,JNJ-678

Target: EGFR, RSV

Cat.No: T30527

Synonym: CHEMBL238103,UNII-MKS21EJ435,BMS 043,BMS488043,BMS 488043

Target: HIV Protease

Cat.No: T17107

Target: Others

Cat.No: T28604

Synonym: RO 5464466,RO-5464466

Cat.No: T15625

Target: Others

Cat.No: T68413

BMS-433771 free base

Cat.No: T26848

Synonym: BMS-433771,BMS 433771,BMS433771

Cat.No: T27271

Synonym: BTA-585,BTA 585,BTAC585,BTA585,BTA-C585

Cat.No: T28133

Umifenovir hydrochloride monohydrate

Cat.No: T68493

Syncytial Virus Inhibitor-1

Cat.No: T13046

Target: Others

Cat.No: T27983

Synonym: MBX-2546,MBX 2546

Cat.No: T27668

Synonym: R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500

Cat.No: T40114

Cat.No: T77094

Cat.No: T79444

Target: Influenza Virus

Cat.No: T77158

Cat.No: T7911

Peniterphenyl A

Cat.No: T75444

Cat.No: T76292

Glycoprotein B (485-492)

Cat.No: T22800

Target: Others

Cat.No: T63433

Cat.No: T77021

COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

Cat.No: T75102

Cat. No.	Product Name	Target	Signaling Pathways
T0884	1-Docosanol Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol	Antifection; HSV	Microbiology/Virology
	1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇，局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。

天然产物

Cat.No: T0884

Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Target: Antifection, HSV

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