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Search Results for " ubiquitin-proteasome system "

1213

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8745	PROTAC BRAF-V600E degrader-1 Compound 23	Raf	MAPK
	PROTAC BRAF-V600E degrader-1 (Compound 23) 选择性地诱导 BRAF-V600E 的降解，而不是野生型 BRAF。
T13554	Arimoclomol maleate BRX-220	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元，进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除
T13553	Arimoclomol 阿瑞洛莫,BRX-220 free base	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol (BRX-220 free base) 是热休克蛋白 (HSP) 的共诱导剂，可用于治疗肌萎缩侧索硬化症的研究。
T14450	Azido-PEG4-hydrazide	Others	Others
	Azido-PEG4-hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17753	DBCO-mPEG (MW 5kDa)	Others	Others
	DBCO-mPEG (MW 5kDa) 是一种基于 PEG 的 PROTAC 连接物，可用于合成 PROTAC。
T17014	TCO-NHS ester	Others; PROTAC Linker	Others; PROTAC
	TCO-NHS ester 是一种 PROTAC linker，属于 alkyl/ether 类。可用于合成 PROTAC 分子。
T17719	Cbz-NH-PEG12-C2-acid	Others; PROTAC Linker	Others; PROTAC
	Cbz-NH-PEG12-C2-acid 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17441	Amino-PEG9-alcohol 胺基-九聚乙二醇	Others; PROTAC Linker	Others; PROTAC
	Amino-PEG9-alcohol 是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。
T17978	Fmoc-PEG12-NHS ester	Others; PROTAC Linker	Others; PROTAC
	Fmoc-PEG12-NHS ester 是 PEG 类 PROTAC linker。可用于合成 PROTAC 分子。
T12579	RAMB4 PTP1B-IN-9	Proteasome	Proteases/Proteasome; Ubiquitination
	RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源，是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
T74793	USP28-IN-3	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP28-IN-3是一种高选择性 USP28 抑制剂，对USP28的IC50 值为 0.1 μM。USP28-IN-3 具有抗癌活性，抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-3 对人结直肠癌和肺鳞癌细胞具有细胞毒性，通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。
T74794	USP28-IN-4	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP28-IN-4 是一种高效的 USP28 抑制剂，对 USP28 的 IC50 值为 0.04 μM。USP28-IN-4 具有抗癌活性，抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-4 对人结直肠癌和肺鳞癌细胞具有细胞毒性，通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。
T15473	Heptaethylene glycol HO-PEG7-OH	Others	Others
	Heptaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16457	PEG3-methylamine	Others	Others
	PEG3-methylamine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40352	Dimethylamino-PEG3 Dimethylamino-PEG3
	Dimethylamino-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16459	PEG4-Ms	Others	Others
	PEG4-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16337	Nonaethylene glycol	Others	Others
	Nonaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38426	Benzyl-PEG4-THP Benzyl-PEG4-THP
	Benzyl-PEG4-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14182	Alkyne-ethyl-PEG1-Boc Alkyne-ethyl-PEG1-t-butyl ester	Others	Others
	Alkyne-ethyl-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17556	Biotin-PEG11-azide	Others	Others
	Biotin-PEG11-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17132	Tos-PEG4-CH2COOH	Others	Others
	Tos-PEG4-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18273	Mal-PEG12-DSPE	Others	Others
	Mal-PEG12-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17131	Tos-PEG4-CH2-Boc	Others	Others
	Tos-PEG4-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15764	Lipoamido-PEG4-acid	Others	Others
	Lipoamido-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38705	MS-PEG1-THP MS-PEG1-THP
	MS-PEG1-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18492	NH2-PEG5-C1-Boc	Others	Others
	NH2-PEG5-C1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14013	2-(Benzyloxy)ethanol	Others	Others
	2-(Benzyloxy)ethanol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39728	Amine-PEG3-Desthiobiotin Amine-PEG3-Desthiobiotin
	Amine-PEG3-Desthiobiotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38498	Azido-PEG12-alcohol Azido-PEG12-alcohol
	Azido-PEG12-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17516	Azido-PEG5-maleimide	Others	Others
	Azido-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15928	m-PEG8-azide	Others	Others
	m-PEG8-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14769	Br-PEG3-CH2COOH	Others	Others
	Br-PEG3-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14811	Bromo-PEG6-alcohol	Others	Others
	Bromo-PEG6-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40494	Bis-isopropyl-PEG1 Bis-isopropyl-PEG1
	Bis-isopropyl-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40198	Azido-PEG11-CH2COOH Azido-PEG11-CH2COOH
	Azido-PEG11-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18482	NH-bis(PEG3-acid)	Others	Others
	NH-bis(PEG3-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17467	Azide-PEG2-Ms	Others	Others
	Azide-PEG2-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18172	m-PEG24-SH	Others	Others
	m-PEG24-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17439	Amino-PEG6-Thalidomide	Others	Others
	Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17597	Biotin-PEG9-CH2CH2COOH	Others	Others
	Biotin-PEG9-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18576	Propargyl-PEG24-amine	Others	Others
	Propargyl-PEG24-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17426	Amino-PEG28-acid	Others	Others
	Amino-PEG28-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38520	Benzyl-PEG8-Ots Benzyl-PEG8-Ots
	Benzyl-PEG8-Ots is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18771	TCO-PEG36-acid	Others	Others
	TCO-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14274	Aminooxy-PEG4-CH2-Boc	Others	Others
	Aminooxy-PEG4-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15955	Mal-Amido-PEG4-Boc	Others	Others
	Mal-Amido-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15864	m-PEG3-S-Acetyl	Others	Others
	m-PEG3-S-Acetyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14414	Azido-PEG10-amine	Others	Others
	Azido-PEG10-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14405	Azido-PEG1-C2-acid	Others	Others
	Azido-PEG1-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17936	endo-BCN-PEG3-NH2	Others	Others
	endo-BCN-PEG3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

化合物

PROTAC BRAF-V600E degrader-1

Cat.No: T8745

Synonym: Compound 23

Target: Raf

Arimoclomol maleate

Cat.No: T13554

Synonym: BRX-220

Target: HSP

Cat.No: T13553

Synonym: 阿瑞洛莫,BRX-220 free base

Target: HSP

Azido-PEG4-hydrazide

Cat.No: T14450

Target: Others

DBCO-mPEG (MW 5kDa)

Cat.No: T17753

Target: Others

Cat.No: T17014

Target: Others, PROTAC Linker

Cbz-NH-PEG12-C2-acid

Cat.No: T17719

Target: Others, PROTAC Linker

Amino-PEG9-alcohol

Cat.No: T17441

Synonym: 胺基-九聚乙二醇

Target: Others, PROTAC Linker

Fmoc-PEG12-NHS ester

Cat.No: T17978

Target: Others, PROTAC Linker

Cat.No: T12579

Synonym: PTP1B-IN-9

Target: Proteasome

Cat.No: T74793

Target: DUB

Cat.No: T74794

Target: DUB

Heptaethylene glycol

Cat.No: T15473

Synonym: HO-PEG7-OH

Target: Others

PEG3-methylamine

Cat.No: T16457

Target: Others

Dimethylamino-PEG3

Cat.No: T40352

Synonym: Dimethylamino-PEG3

Cat.No: T16459

Target: Others

Nonaethylene glycol

Cat.No: T16337

Target: Others

Benzyl-PEG4-THP

Cat.No: T38426

Synonym: Benzyl-PEG4-THP

Alkyne-ethyl-PEG1-Boc

Cat.No: T14182

Synonym: Alkyne-ethyl-PEG1-t-butyl ester

Target: Others

Biotin-PEG11-azide

Cat.No: T17556

Target: Others

Tos-PEG4-CH2COOH

Cat.No: T17132

Target: Others

Cat.No: T18273

Target: Others

Tos-PEG4-CH2-Boc

Cat.No: T17131

Target: Others

Lipoamido-PEG4-acid

Cat.No: T15764

Target: Others

Cat.No: T38705

Synonym: MS-PEG1-THP

NH2-PEG5-C1-Boc

Cat.No: T18492

Target: Others

2-(Benzyloxy)ethanol

Cat.No: T14013

Target: Others

Amine-PEG3-Desthiobiotin

Cat.No: T39728

Synonym: Amine-PEG3-Desthiobiotin

Azido-PEG12-alcohol

Cat.No: T38498

Synonym: Azido-PEG12-alcohol

Azido-PEG5-maleimide

Cat.No: T17516

Target: Others

Cat.No: T15928

Target: Others

Br-PEG3-CH2COOH

Cat.No: T14769

Target: Others

Bromo-PEG6-alcohol

Cat.No: T14811

Target: Others

Bis-isopropyl-PEG1

Cat.No: T40494

Synonym: Bis-isopropyl-PEG1

Azido-PEG11-CH2COOH

Cat.No: T40198

Synonym: Azido-PEG11-CH2COOH

NH-bis(PEG3-acid)

Cat.No: T18482

Target: Others

Cat.No: T17467

Target: Others

Cat.No: T18172

Target: Others

Amino-PEG6-Thalidomide

Cat.No: T17439

Target: Others

Biotin-PEG9-CH2CH2COOH

Cat.No: T17597

Target: Others

Propargyl-PEG24-amine

Cat.No: T18576

Target: Others

Amino-PEG28-acid

Cat.No: T17426

Target: Others

Benzyl-PEG8-Ots

Cat.No: T38520

Synonym: Benzyl-PEG8-Ots

Cat.No: T18771

Target: Others

Aminooxy-PEG4-CH2-Boc

Cat.No: T14274

Target: Others

Mal-Amido-PEG4-Boc

Cat.No: T15955

Target: Others

m-PEG3-S-Acetyl

Cat.No: T15864

Target: Others

Azido-PEG10-amine

Cat.No: T14414

Target: Others

Azido-PEG1-C2-acid

Cat.No: T14405

Target: Others

endo-BCN-PEG3-NH2

Cat.No: T17936

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T75488	Leptosphaerodione
	Leptosphaerodione，可从 Remotididymellasp. 中分离得到，是一种有效的泛素-蛋白酶体系统 (UPS) 抑制剂。Leptosphaerodione 在 HeLa 细胞中具有细胞毒性，IC50为 3.2 μM。抗肿瘤剂。
T79941	Antimycin A2c	Apoptosis	Apoptosis
	Anticanceragent 141（compound AE）是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能，诱导caspase依赖性细胞凋亡，并激活ROS介导的泛素依赖性蛋白酶体系统，进而引起E6/E7癌蛋白的降解。

天然产物

Leptosphaerodione

Cat.No: T75488

Cat.No: T79941

Target: Apoptosis

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