Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7776 |
ADH-503
GB1275 |
Complement System | Immunology/Inflammation |
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。 | |||
T13379 |
(Z)-Leukadherin-1
ADH-503 free base |
Complement System | Immunology/Inflammation |
(Z)-Leukadherin-1 (ADH-503 free base) 是 CD11b 的变构激动剂。 | |||
T26699 |
AZ10397767
AZ 10397767,AZ-10397767 |
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AZ10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). AZ10397767 significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models. | |||
T71890 |
F5446
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F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape. | |||
T76410 |
Tyrosinase (206-214), human
|
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Tyrosinase(206-214), human (AFLPWHRLF),一种由9个氨基酸组成的肽,为酪氨酸酶的表位。可被HLA-A24限制性肿瘤浸润淋巴细胞(TIL)识别的Tyrosinase(206-214), human,具有重要生物医学意义。 | |||
T79528 | SWS1 | PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
SWS1为d-(+)-生物素缀合的PD-L1抑制剂(IC50: 1.8 nM),显示出抗癌潜力。该化合物能提高肿瘤浸润淋巴细胞数量,并在B16-F10小鼠模型中展现抗肿瘤效果(TGI=66.1%)。 | |||
T77090 | Mitazalimab | ||
Mitazalimab(ADC-1013; JNJ-64457107)是一种FcγR依赖性CD40激动剂,以肿瘤导向活性为特征。该化合物通过激活抗原呈递细胞(如树突状细胞[DC]),启动肿瘤反应性T细胞,进而诱导肿瘤特异性T细胞浸润并杀死肿瘤,有效重塑肿瘤浸润性骨髓微环境。 | |||
T70928 |
CB-1158-analog
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CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cell... | |||
T78053 |
PD-L1-IN-2
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PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
"PD-L1-IN-2是一种具有潜力的肿瘤免疫治疗剂,具有抑制PD-L1的活性。该化合物为Naamidine J的衍生物,可通过降低体内PD-L1的表达并增强肿瘤浸润性T细胞的免疫反应来发挥抗肿瘤效果。PD-L1-IN-2主要应用于结直肠癌的研究领域。" |