Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Z)-Leukadherin-1 (ADH-503 free base) 是 CD11b 的变构激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 269 | 5日内发货 | ||
5 mg | ¥ 455 | 5日内发货 | ||
10 mg | ¥ 747 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 493 | 5日内发货 |
(Z)-Leukadherin-1 的其他形式现货产品:
产品描述 | (Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
体外活性 | (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1]. |
体内活性 | (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. |
别名 | ADH-503 free base |
分子量 | 421.49 |
分子式 | C22H15NO4S2 |
CAS No. | 2055362-72-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (9.49 mM), ultrasonic and warming and heat to 60°C
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3725 mL | 11.8627 mL | 23.7254 mL | 59.3134 mL |
5 mM | 0.4745 mL | 2.3725 mL | 4.7451 mL | 11.8627 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(Z)-Leukadherin-1 2055362-72-4 Immunology/Inflammation Complement System orally macrophages ADH-503 repolarization ADH 503 ADH-503 free base dendritic allosteric CD11b tumorassociated ADH503 (Z)Leukadherin1 Inhibitor (Z) Leukadherin 1 tumor-infiltrating inhibit Leukadherin-1 immunosuppressive inhibitor