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Search Results for " tetrahydrofolate "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7598	Calcium N5-methyltetrahydrofolate 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328	Others; Antifolate	Cell Cycle/Checkpoint; Others
	Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐，用于治疗心血管疾病、乳腺癌和结肠直肠癌。
T29461	5-Methyltetrahydrofolate triglutamate 5-Me-Thf(glu)3
	5-Methyltetrahydrofolate triglutamate is a form of folic acid.
T8003	Methotrexate disodium	Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Methotrexate disodium 是一种叶酸类似物代谢抑制剂，具有免疫抑制剂和抗肿瘤特性，用于类风湿关节炎和研究多种癌症。
T11103	DS18561882	Others	Others
	DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063.
T20339	7-Hydroxymethotrexate NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962	Drug Metabolite	Metabolism
	7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用，抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。
T24985	5-Monobutyl methotrexate NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986
	5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component
T69177	Methotrexate di-n-butyl ester
	Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
T25374	Emofolin sodium NSC139490,MeTHHF disodium,NSC-139490,NSC 139490
	Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, deple
T69257	Methotrexate diethyl ester
	Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
T76131	Sarcosine oxidase
	Sarcosine oxidase(SAO)，即肌氨酸氧化酶，可以催化肌氨酸的氧化去甲基化生成甘氨酸，H2O2, 5,10-CH2-四氢叶酸，常用于生化反应。
T7730L	Aminopterin sodium NSC739,NSC 739 [as the base],NSC-739
	Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe
T37998	N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)
	N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)
T25980	Pralatrexate, (R)-
	Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr
T25079	Aminopterin N-hydroxysuccinimide ester Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
	Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof
T25981	Pralatrexate, (S)-
	Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr
T74009	1,1,3-Tribromoacetone
	1,1,3-Tribromoacetone 是甲氨蝶呤的杂质。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。
T32705	Levomefolate magnesium L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th

化合物

Calcium N5-methyltetrahydrofolate

Cat.No: T7598

Synonym: 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328

Target: Others, Antifolate

5-Methyltetrahydrofolate triglutamate

Cat.No: T29461

Synonym: 5-Me-Thf(glu)3

Methotrexate disodium

Cat.No: T8003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Cat.No: T11103

Target: Others

7-Hydroxymethotrexate

Cat.No: T20339

Synonym: NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962

Target: Drug Metabolite

5-Monobutyl methotrexate

Cat.No: T24985

Synonym: NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986

Methotrexate di-n-butyl ester

Cat.No: T69177

Emofolin sodium

Cat.No: T25374

Synonym: NSC139490,MeTHHF disodium,NSC-139490,NSC 139490

Methotrexate diethyl ester

Cat.No: T69257

Sarcosine oxidase

Cat.No: T76131

Aminopterin sodium

Cat.No: T7730L

Synonym: NSC739,NSC 739 [as the base],NSC-739

N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)

Cat.No: T37998

Pralatrexate, (R)-

Cat.No: T25980

Aminopterin N-hydroxysuccinimide ester

Cat.No: T25079

Synonym: Nhs-aminopterin,N-Hydroxysuccinimide aminopterin

Pralatrexate, (S)-

Cat.No: T25981

1,1,3-Tribromoacetone

Cat.No: T74009

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

Cat. No.	Product Name	Target	Signaling Pathways
T1153	Trimethoprim NIH 204,BW 56-72,甲氧苄啶,NSC-106568	DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Trimethoprim (NSC-106568) 是抑菌抗生素，也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性，可用于尿路感染，肺孢子菌肺炎和志贺氏菌病的研究。
T13516	5-Methyltetrahydrofolic acid 甲基叶酸盐,5-Methyl THF	Endogenous Metabolite	Metabolism
	5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物，具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。

天然产物

Cat.No: T1153

Synonym: NIH 204,BW 56-72,甲氧苄啶,NSC-106568

Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic

5-Methyltetrahydrofolic acid

Cat.No: T13516

Synonym: 甲基叶酸盐,5-Methyl THF

Target: Endogenous Metabolite

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