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Search Results for " squalene "

30

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81109	Squalene synthase-IN-1
	Squalene synthase-IN-1（compound 1）是一种通过抑制Squalene Synthase来发挥降血脂作用的有效药物。该化合物也展现了卓越的抗氧化和抗炎特性，能显著降低葡萄糖水平和氧化应激，且不引起毒性。
T4066	FIN56	Ferroptosis	Apoptosis
	FIN56 是一种铁死亡特异性诱导剂，能结合并激活角鲨烯合酶，可通过诱导 GPX4 降解来诱导铁死亡。
T1497	Liranaftate Piritetrate,利拉萘酯,M-732	Antifungal	Microbiology/Virology
	Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂，可研究皮肤癣菌。
T11321	FR194738 free base	Antifungal	Microbiology/Virology
	FR194738 free base 抑制 HepG2 细胞匀浆中的角鲨烯环氧酶活性，IC50 为 9.8 nM。
TQ0115	NB-598	Antifungal	Microbiology/Virology
	NB-598 是一种鲨烯环氧化酶竞争性抑制剂，可以阻碍甘油三酯的生物合成。
T1217	Butenafine hydrochloride KP363 (Hydrochloride),Butenafine HCl,KP-363,盐酸布替萘芬	Antibiotic; Antifungal	Microbiology/Virology
	Butenafine hydrochloride (KP363 Hydrochloride) 通过抑制鲨烯环氧酶阻断甾醇的合成，具有抗真菌活性。
T1543	Naftifine hydrochloride Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Stem Cells
	Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性，对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
T83658	SQLE-IN-1	Antifungal	Microbiology/Virology
	SQLE-IN-1 是一种角鲨烯环氧化酶 (SQLE) 抑制剂，具有抗肿瘤活性，可抑制肝癌细胞系 Huh7 的增殖和迁移能力，抑制细胞胆固醇的生成，增加抑癌基因PTEN的表达，抑制PI3K和AKT的蛋白表达。
T12765	RPR107393 free base	Others	Others
	RPR107393 free base is a selective inhibitor of squalene synthase(rat liver microsomal squalene synthase, with an IC50 of 0.8 nM).
T24826	Squalestatin 3
	Squalestatin 3 is an inhibitor of squalene synthase.
T24825	Squalestatin 2
	Squalestatin 2 is an inhibitor of squalene synthase.
T26345	YM-53601 YM53601
	YM-53601 is a squalene synthase activity inhibitor that acts by lowering cholesterol as well as triglycerides.
T27646	J-104118 J 104118
	J-104118 potentially inhibits squalene synthase.
T27231	E5700 E 5700,E-5700
	E5700 is a novel squalene synthase inhibitor with oral activity.
T12199	NB-598 Maleate	Others	Others
	NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.
T29189	YM-75440 YM75440
	YM-75440 is an squalene synthase inhibitor with oral activity.
T70435	BMS-187745
	BMS-187745 is a squalene synthase inhibitor.
T30499	BMS-188494 UNII-F4W2579G7P
	BMS-188494 is a squalene synthase inhibitor used as an anti-cholesterol drug.
T12199L	NB-598 hydrochloride	Antifungal	Microbiology/Virology
	NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.
T25317	DF-461 DF 461
	DF-461 is an inhibitor of squalene synthase.
T15709	Lapaquistat acetate TAK-475	Others	Others
	Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholester
T24710	Zaragozic acid C L697350,L-697,350,L 697,350,L 697350,L-697350
	Zaragozic acid C is an effective inhibitor of squalene synthase.
T23767	WC-9 WC 9
	WC-9 is a squalene synthase inhibitor. It acts by binding to TcSQS and HsSQS.
T26348	Zaragozic acid D(2)
	Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T13371	YM-53601 free base	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
T26347	Zaragozic acid D
	Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T6702L	Terbinafine lactate DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
	Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.
T21365	Butenafine KP363,KP 363,Mentax,KP-363,Butop
	Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to leak out.
T11320	FR194738	Antifungal	Microbiology/Virology
	FR194738 是一种角鲨烯环氧酶抑制剂，在 HepG2 细胞匀浆中的 IC50 为 9.8 nM。
T35503	(±)-5,7-Dimethyltocol
	(±)-5,7-Dimethyltocol is a form of tocopherol. It has similar antioxidant activity to α-tocol, but lower activity than γ-tocol, in antioxidant assays using menhaden oil or squalene as substrates. It also increases microviscosity of rat liver liposomes containing phosphatidylcholine (PC) by 70.6% when used at a molar ratio of 0.2 to PC. (±)-Dimethyltocol has been used as an internal standard for the quantification of 5,7-tocol, α- and γ-tocopherol, and α- and γ-tocopheryl quinone by HPLC.

化合物

Squalene synthase-IN-1

Cat.No: T81109

Cat.No: T4066

Target: Ferroptosis

Cat.No: T1497

Synonym: Piritetrate,利拉萘酯,M-732

Target: Antifungal

FR194738 free base

Cat.No: T11321

Target: Antifungal

Cat.No: TQ0115

Target: Antifungal

Butenafine hydrochloride

Cat.No: T1217

Synonym: KP363 (Hydrochloride),Butenafine HCl,KP-363,盐酸布替萘芬

Target: Antibiotic, Antifungal

Naftifine hydrochloride

Cat.No: T1543

Synonym: Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil

Target: Hedgehog/Smoothened, Antibiotic, Antifungal

Cat.No: T83658

Target: Antifungal

RPR107393 free base

Cat.No: T12765

Target: Others

Cat.No: T24826

Cat.No: T24825

Cat.No: T26345

Synonym: YM53601

Cat.No: T27646

Synonym: J 104118

Cat.No: T27231

Synonym: E 5700,E-5700

Cat.No: T12199

Target: Others

Cat.No: T29189

Synonym: YM75440

Cat.No: T70435

Cat.No: T30499

Synonym: UNII-F4W2579G7P

NB-598 hydrochloride

Cat.No: T12199L

Target: Antifungal

Cat.No: T25317

Synonym: DF 461

Lapaquistat acetate

Cat.No: T15709

Synonym: TAK-475

Target: Others

Zaragozic acid C

Cat.No: T24710

Synonym: L697350,L-697,350,L 697,350,L 697350,L-697350

Cat.No: T23767

Synonym: WC 9

Zaragozic acid D(2)

Cat.No: T26348

YM-53601 free base

Cat.No: T13371

Target: AMPK

Zaragozic acid D

Cat.No: T26347

Terbinafine lactate

Cat.No: T6702L

Synonym: DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT

Cat.No: T21365

Synonym: KP363,KP 363,Mentax,KP-363,Butop

Cat.No: T11320

Target: Antifungal

(±)-5,7-Dimethyltocol

Cat.No: T35503

Cat. No.	Product Name	Target	Signaling Pathways
T4749	Squalene 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species; Endogenous Metabolite; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Squalene (AddaVax) 是胆固醇合成的中间产物，具有降血脂、保肝、心脏保护、抗氧化和抗毒活性等多种药理特性。它还具有抗真菌活性，可用于毛癣菌治疗的相关研究。
T75636	(E/Z)-Squalene (E/Z)-Super Squalene,(E/Z)-AddaVax
	(E/Z)-Squalen 调节细胞内活性氧化物质 (ROS) 的产生，并呈浓度和时间依赖性引起细胞凋亡和坏死。(E/Z)-Squalene ((E/Z)-AddaVax) 在肝脏中积累并降低肝脏胆固醇和甘油三酯。
TN5051	Squalene-2,3-diol	Others	Others
	Squalene-2,3-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5051，CAS号为 14031-37-9。
TN1576	Diallyl disulfide	IL Receptor; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Diallyl disulfide 能够抑制人角鲨烯单加氧酶，抑制角鲨烯环氧化的 IC50为 400 μM。它也具有抗肿瘤作用，同miR-200b 和miR-22联合使用可增强该作用。
T5613	Squalane 角鲨烷,Dodecahydrosqualene,Perhydrosqualene	Others	Others
	Squalane (Perhydrosqualene) 是某些鱼油 (尤其是鲨鱼肝油) 和某些植物油中存在的脂质。它具有抗癌，抗氧化作用，可用作皮肤保湿和润肤剂。
T6702	Terbinafine Terbinex,特比萘芬,SF 86-327,Lamisil,TDT 067	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Terbinafine (TDT 067) 是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂，Ki 值为 30 nM。它具有抗真菌感染活性。
T1411	Terbinafine hydrochloride KWD 2019,盐酸特比萘芬,Terbinafine HCl,TDT 067 hydrochloride	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Terbinafine hydrochloride (KWD 2019) 具有抗真菌感染活性。它是念珠菌属的角鲨烯环氧化酶的非竞争性抑制剂，Ki 值为 30 nM。它还对某些革兰氏阳性和革兰氏阴性细菌具有抗菌活性。
TN5134	Tetrahydroxysqualene	Antifection	Microbiology/Virology
	Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.
T31520	Diplopterol
	Diplopterol is biosynthetic of squalene for use in acetobacter pasteurii in a cell-free system. It is a hopanoid and can be used as a substitute for sterols.

天然产物

Cat.No: T4749

Synonym: 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene

Target: Reactive Oxygen Species, Endogenous Metabolite, Antifungal

(E/Z)-Squalene

Cat.No: T75636

Synonym: (E/Z)-Super Squalene,(E/Z)-AddaVax

Squalene-2,3-diol

Cat.No: TN5051

Target: Others

Diallyl disulfide

Cat.No: TN1576

Target: IL Receptor, NOS, NF-κB

Cat.No: T5613

Synonym: 角鲨烷,Dodecahydrosqualene,Perhydrosqualene

Target: Others

Cat.No: T6702

Synonym: Terbinex,特比萘芬,SF 86-327,Lamisil,TDT 067

Target: Antibacterial, Antibiotic, Antifungal

Terbinafine hydrochloride

Cat.No: T1411

Synonym: KWD 2019,盐酸特比萘芬,Terbinafine HCl,TDT 067 hydrochloride

Target: Antibacterial, Antibiotic, Antifungal

Tetrahydroxysqualene

Cat.No: TN5134

Target: Antifection

Cat.No: T31520

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