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15

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19914	Chlorothalonil DAC 2787,Daconil,Daconil M,百菌清	Antifungal	Microbiology/Virology
	Chlorothalonil (DAC 2787) 是一种高效低毒广谱的杀菌剂，广泛用于防治果树、蔬菜菜叶等多种害虫，对水稻、小麦、棉花等多种病害，也具有较好的防治效果。
T124276	4-Deacetylneosolaniol
	4-Deacetylneosolaniol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124276，CAS号为 74833-39-9。
T77656	LW3	Antifungal	Microbiology/Virology
	LW3 是一种有效的广谱抗真菌化合物。 LW3 具有抗真菌活性，对 B. cinerea、R. solani、S. sclerotiorum 和 F. graminearum 具有抑制作用， EC50 值分别为 0.54、0.09、1.52 和 2.65 mg/L。
T7592	Trifloxystrobin CGA 279202,肟菌酯	Antifungal	Microbiology/Virology
	Trifloxystrobin (CGA 279202) 是一种杀菌剂，可抑制从甜菜作物中分离出的立枯病菌的生长。对大型水蚤新生儿和胚胎的 EC50 分别为 23.0 μg/L 和 1.7 μg/L。
T68907	Flutolanil
	Flutolanil is a benzanilide fungicide. It is active against a panel of 241 field isolates of the plant pathogenic fungus R. solani when grown in flutolanil-enriched growth media. Flutolanil inhibits R. solani hyphal growth and infection cushion formation on rice plant leaf sheaths. It is toxic to zebrafish embryos, larvae, and adults. Formulations containing flutolanil have been used to control fungal infections on rice crops.
T61234	Stemphyperylenol
	Stemphyperylenol exhibits potent antifungal activity against Alternaria solani, a plant pathogen, with a minimum inhibitory concentration (MIC) value of 1.57 μM.
T78931	SDH-IN-5
	SDH-IN-5（化合物7d）是一种琥珀酸脱氢酶（SDH）抑制剂，IC50为3.293 μM。该化合物同时展现出对R. solani具有EC50值为0.046 μg/mL的抗真菌活性，并对水稻叶片中的茄病菌表现出显著的保护和治疗效果。
T40124	Antifungal agent 20
	Antifungal agent 20 demonstrates significant antifungal efficacy against a range of fungal pathogens including Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.
T75473	Eucalyptacid A
	Eucalyptacid A，一种抗真菌代谢产物，在防治番茄早疫病菌方面展现出了活性，其最小抑制浓度（MIC）范围为6.25至50 μM。
T79759	Antifungal agent 74
	Antifungalagent 74 (compound 3c) 是一种高效抗真菌化合物，展现出对C. arachidicola和R. solani的显著杀菌效果。其机制主要通过破坏真核生物的类固醇生物合成及核糖体生物发生来实现。
T78727	SDH-IN-4
	SDH-IN-4 (compound B6) 为琥珀酸脱氢酶 (succinate dehydrogenase (SDH)) 抑制剂，IC50为0.28 μg/mL。该化合物展现出高效广谱的真菌抑制活性，对R. solani的EC50值为0.23 μg/mL。
T36025	Deoxyviolacein
	Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/ml) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentr...
T38353	Pyrenocine A
	Pyrenocine A is a fungal metabolite that has been found inP. terrestrisand has diverse biological activities.1It inhibits the asexual spore germination of the plant pathogenic fungiF. oxysporum,F. solani,M. hiemalis, andR. stolonifer(EC50s = 14, 20, 20, and 25 μg/ml, respectively). Pyrenocine A is active againstB. subtilis,S. aureus, andE. coli(IC50s = 30, 45, and 200 μg/ml, respectively). It inhibits onion seedling elongation (EC50= 4 μg/ml). Pyrenocine A is also a phytotoxin that inhibits lett...
T60949	Complex III-IN-2
	Complex III-IN-2 (Compd 4d-2) 是complex III 的抑制剂，具有抗真菌活性，其对植物病菌立枯病菌和核盘菌的EC50值分别为29.31 mg/L 和 29.98 mg/L。
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...

化合物

Cat.No: T19914

Synonym: DAC 2787,Daconil,Daconil M,百菌清

Target: Antifungal

4-Deacetylneosolaniol

Cat.No: T124276

Cat.No: T77656

Target: Antifungal

Trifloxystrobin

Cat.No: T7592

Synonym: CGA 279202,肟菌酯

Target: Antifungal

Cat.No: T68907

Stemphyperylenol

Cat.No: T61234

Cat.No: T78931

Antifungal agent 20

Cat.No: T40124

Cat.No: T75473

Antifungal agent 74

Cat.No: T79759

Cat.No: T78727

Cat.No: T36025

Cat.No: T38353

Complex III-IN-2

Cat.No: T60949

Cat.No: T37052

Cat. No.	Product Name	Target	Signaling Pathways
Fr13883	3-Methoxyphenylacetic acid	Others	Others
	3-Methoxyphenylacetic acid 是 m-hydroxyphenylacetic (m-OHPAA) 的衍生物，茄形假丝酵母中的一种植物毒素。它可用于针对介氧菌根腐烂的毒素介导的生物测定法的开发。
T12971	Solanidine	Others	Others
	Solanidine 是一种从马铃薯物种中分离出来的胆甾烷生物碱，具有抗肿瘤作用。 Solanidine 具有抑制增殖的作用。
TN1376	α-Solanine alpha-Solanine,A-茄碱	MMP; Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
T13895	Solanidiene 茄次烯碱,Solanthrene	Others	Others
	Solanidiene (Solanthrene) is isolated from the leaves of S. tuberosum .
T16285	Neosolaniol	Potassium Channel	Membrane transporter/Ion channel
	Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.
T2S0491	Isoeugenol acetate 乙酸异丁香酚酯,Isoeugenyl acetate,Acetisoeugenol,Acetylisoeugenol,乙酸异丁香酚酯，乙酰基异丁香酚;2-甲氧基-4-丙烯基苯基乙酸酯	AChE; Antifungal	Microbiology/Virology; Neuroscience
	Isoeugenol acetate (Acetylisoeugenol) 是肉豆蔻，丁香和肉桂的精油成分，对某些代谢酶如乙酰胆碱酯酶，能够抑制α-糖苷酶和 α-淀粉酶。它用于医疗和化妆品工业，具有抗氧化，抗癌，抗菌和抗炎作用。
T82433	Eugenitol 7-Noreugenitin
	Eugenitol (Compound 3) 为从Diaporthe eucalyptorum分离出的抗真菌代谢产物，可抑制四种植物病原真菌（Alternaria solani, Botrytis cinerea, Fusarium solani及Gibberella saubinettii）。
T75474	Cytosporone C
	Cytosporone C 是一种来自 Melia azedarach 相关真菌 Diaporthe eucalyptorum 的抗真菌代谢物。Cytosporone C 具有抗真菌活性，可对抗 Alternaria solani。
TN5039	Sorokinianin	Antifection	Microbiology/Virology
	Sorokinianin is a phytotoxin, it has antifungal activity, it is highly effective in suppressing spore germination of F. solani (75%) at 100 ug/ml concentration.
T73874	Kievitone
	Kievitone 是一种异黄酮，是可以从Rhizoctonia solani Kühn 感染Phaseolus vulgaris L.的下胚轴中分离出来。Kievitone 具有抗真菌活性和抗肿瘤活性。
TN1063	Calycanthine 蜡梅碱,腊梅碱	Antifection	Microbiology/Virology
	D-calycanthine has antifungal activity, it shows significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium.
T37712	Fumiquinazoline D
	Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 μg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 μg/ml, respectively).
T60702	Globosuxanthone A
	Globosuxanthone A 是一种具有抗癌活性的二氢黄嘌呤酮。Globosuxanthone A 对禾谷镰刀菌、茄镰刀菌和灰霉病菌表现出显著的抗真菌活性，MIC 值分别为 4、8 和 16 μg/mL。。
T75476	Monaschromone
	Monaschromone 是一种聚酮代谢物，可显著抑制灰霉病菌、茄病菌、稻瘟病菌和索比内蒂菌的生长，MIC 值在 6.25 至 12.5 μM 之间。
T75475	Chaetosemin J
	Chaetosemin J，一种对植物病原真菌（如灰霉病菌、番茄交链孢菌、稻瘟病菌和赤霉素）具有抑制活性的抗真菌代谢产物，MIC值在12.5-25 μM范围内。
T38268	Validamycin A
	Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM; IC50 = 0.7 μM). It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi. This compound has also been used to study trehalase activity and trehalose biosynthesis.
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...

天然产物

3-Methoxyphenylacetic acid

Cat.No: Fr13883

Target: Others

Cat.No: T12971

Target: Others

Cat.No: TN1376

Synonym: alpha-Solanine,A-茄碱

Target: MMP, Akt, PI3K

Cat.No: T13895

Synonym: 茄次烯碱,Solanthrene

Target: Others

Cat.No: T16285

Target: Potassium Channel

Isoeugenol acetate

Cat.No: T2S0491

Synonym: 乙酸异丁香酚酯,Isoeugenyl acetate,Acetisoeugenol,Acetylisoeugenol,乙酸异丁香酚酯，乙酰基异丁香酚;2-甲氧基-4-丙烯基苯基乙酸酯

Target: AChE, Antifungal

Cat.No: T82433

Synonym: 7-Noreugenitin

Cat.No: T75474

Cat.No: TN5039

Target: Antifection

Cat.No: T73874

Cat.No: TN1063

Synonym: 蜡梅碱,腊梅碱

Target: Antifection

Fumiquinazoline D

Cat.No: T37712

Globosuxanthone A

Cat.No: T60702

Cat.No: T75476

Cat.No: T75475

Cat.No: T38268

Cat.No: T35741

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