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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T5421 KDU691

Parasite; PI4K Microbiology/Virology; PI3K/Akt/mTOR signaling
KDU691 是一种咪唑吡嗪类药物,对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性,它是 PI4K 抑制剂,选择性抑制双氢青蒿素预处理的恶性疟原虫。
T0850 Primaquine diphosphate

Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹

Antibiotic; Parasite Microbiology/Virology
Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物,具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。
T70507 KAI-407

KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compou...

化合物

KDU691
Cat.No: T5421
Synonym:
Target: Parasite, PI4K
Primaquine diphosphate
Cat.No: T0850
Synonym: Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹
Target: Antibiotic, Parasite
KAI-407
Cat.No: T70507
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN4683 Nyasol

ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly

天然产物

Nyasol
Cat.No: TN4683
Synonym:
Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection
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