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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8930 |
CID44216842
KUC103479N-02 |
CDK; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。 | |||
T68051 |
Delequamine
RS 15385-197 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Delequamine (RS 15385-197) 是一种有效的选择性 α2-肾上腺素受体拮抗剂。 | |||
T77660 |
TINK-IN-1
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
TINK-IN-1 是一种具有选择性和高效性的 TNIK 抑制剂(IC50:8 nM)。TINK-IN-1 抑制结直肠癌细胞活力,可用于研究智力发育障碍。 | |||
T39800 |
S2116
|
||
S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4763 |
trans-Cyclohexane-1,2-diol
trans-1,2-Cyclohexanediol,反式-1,2-环己二醇 |
Others; Endogenous Metabolite | Metabolism; Others |
trans-Cyclohexane-1,2-diol (trans-1,2-Cyclohexanediol) 是内源性代谢产物的一种。 | |||
T5295 |
1-Hydroxyoctadecane
硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol |
Others; Endogenous Metabolite | Metabolism; Others |
1-Hydroxyoctadecane (OctadecanolOctadecanol) 是内源性代谢产物的一种。 | |||
T13797 |
Nivalenol
|
Caspase | Apoptosis; Proteases/Proteasome |
Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡,从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。 |