Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7833 |
TLX agonist 1
|
Others | Others |
TLX agonist 1 是一种孤核受体tailless (TLX, NR2E1)调节剂 (EC50=1 μM;Kd= 650 nM)。它能够提高 TLX 转录抑制活性。 | |||
T13974 |
ZL0580
|
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。 | |||
T29231 |
ZLD1039
ZLD-1039,ZLD 1039 |
Histone Methyltransferase | Chromatin/Epigenetic |
ZLD1039 是一种口服有效的、高选择性 EZH2 抑制剂。ZLD1039 高效抑制 EZH2 野生型及 Y641F 和 A677G 突变型,IC50 分别为 5.6、15 和 4.0 nM。ZLD1039 抑制乳腺肿瘤的生长和转移。 | |||
T17002 |
Tazemetostat hydrobromide
E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide |
Histone Methyltransferase | Chromatin/Epigenetic |
Tazemetostat hydrobromide (E-7438 hydrobromide) 是口服的EZH2选择性抑制剂。它抑制含有 PRC2 复合体的野生型 EZH2 的活性,Ki 为 2.5 nM。它还抑制 EZH1,IC50为 392 nM。 | |||
T13954 |
UNC6852
|
Histone Methyltransferase; Ligands for Target Protein for PROTAC; PROTACs | Chromatin/Epigenetic; PROTAC |
UNC6852 包含一个 EED 配体 (IC50 = 247 nM) 和一个 von Hippel-Lindau 配体,是一种基于 PROTAC 的特异性多梳抑制复合物 2 (PRC2) 降解剂。 | |||
T10205 |
A-395
|
Histone Methyltransferase | Chromatin/Epigenetic |
A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂,可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12),IC50为 18 nM。 | |||
T12554 |
PROTAC EED degrader-2
|
Others; PROTACs | Others; PROTAC |
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11. | |||
T61825 | EED ligand 1 | ||
EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase. | |||
T12553 |
PROTAC EED degrader-1
|
Others; PROTACs | Others; PROTAC |
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17. | |||
T36627 |
Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
|
||
Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protei... |