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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8657 |
KYP-2047
|
Others | Others |
KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。 | |||
T9855 |
BR102910
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- |
Others | Others |
BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) 是一种选择性的成纤维细胞活化蛋白(FAP)的抑制剂。 | |||
T61622 |
PREP inhibitor-1
|
Others | Others |
PREP inhibitor-1 是一种 prolyl oligopeptidase (PREP) 抑制剂,可用于研究阿尔茨海默症。 | |||
T21011 |
Buspirone
Buspirone free base,Ansial,丁螺环酮 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Buspirone (Buspirone free base) 是一种azaspiro 化合物,具有抗焦虑药、镇静剂、血清素能激动剂和EC 3.4.21.26(脯氨酸寡肽酶)抑制剂的作用。 | |||
T7890 |
SP-13786
UAMC-1110,(S)-N-[2-(2-氰基-4,4-二氟-1-吡咯烷基)-2-氧代乙基]喹啉-4-甲酰胺 |
Others | Others |
SP-13786 (UAMC-1110) 是成纤维细胞活化蛋白 (FAP) 的抑制剂 (IC50 : 3.2 nM);还抑制脯氨酰寡肽酶 (PREP) ( IC50 : 1.8 μM)。 | |||
T78619 |
Z-Pro-Pro-CHO
|
Prolyl Endopeptidase (PREP) | Metabolism; Proteases/Proteasome |
Z-Pro-Pro-CHO为一种有效的脯氨酰寡肽酶抑制剂,其具有针对人类及曼氏血吸虫脯氨酰寡肽酶的较低半抑制浓度(IC50),分别为0.16 μM和0.01 μM。 | |||
T62534 | POP-IN-2 | ||
POP-IN-2 (Compound 7k) 是一种有效的、共价结合的 prolyl oligopeptidase (POP) 抑制剂 (Ki: 6 nM)。POP-IN-2 能够用于神经退行性疾病和癌症的研究。 | |||
T61995 |
Y-29794
|
||
Y-29794 (Compound 2) 是一种有效的、共价的prolyl oligopeptidase (POP)抑制剂(Ki= 0.95 nM)。Y-29794 在神经退行性疾病和癌症中具有研究价值。 | |||
T69603 |
BR103354
|
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BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (DPP)-related enzymes and prolyl oligopeptidase (PREP). BR103354 exhibited good pharmacokinetic properties as evidenced by oral bioavailability of 48.4% and minimal hERG inhibition. Single co-administration of BR103354 with hFGF21 reduced nonfasting blood glucose concentrations, i... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4442 |
Linderene acetate
|
Prolyl Endopeptidase (PREP) | Metabolism; Proteases/Proteasome |
Linderene acetate 是一种脯氨酸肽链内切酶抑制剂,分离自Lindera strychnifolia 中。 | |||
T2717 |
Salidroside
红景天苷,Rhodioloside |
Apoptosis; mTOR | Apoptosis; PI3K/Akt/mTOR signaling |
Salidroside (Rhodioloside) 是一种从红景天中分离出来的具有生物活性的酚苷化合物,是一种脯氨酰内肽酶抑制剂。它能通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状,还能通过增强 PINK1/Parkin 介导的线粒体自噬来保护多巴胺能神经元。 | |||
T3891 |
Oroxylin A-7-O-glucuronide
Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide |
Others | Others |
Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) 是一种类黄酮葡糖苷酸,提取自 Scutellaria baicalensis 干燥的根中,具有脯氨酰寡肽酶(POP)抑制作用。 | |||
T2S0618 |
β-Elemonic Acid
3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid |
Apoptosis; Reactive Oxygen Species; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜,具有抗癌和抗炎作用。它抑制脯氨酰内肽酶,诱导细胞凋亡,活性氧和COX-2表达。 | |||
TN3714 |
(-)-Corypalmine
Corypalmine |
Antifection | Microbiology/Virology |
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi. | |||
TN4426 |
Leojaponin
|
AChR | Neuroscience |
Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm. |