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35

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5002	Methyl Aminolevulinate Hydrochloride 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride	Others	Others
	Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) 是增敏剂，可用于光动力疗法。Methyl aminolevulinate 是一种前药，可代谢为原卟啉 IX。
T73590	8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY
	8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY 可用于光动力疗法。
T15501	HPPH 光克洛,Photochlor	Others	Others
	HPPH (Photochlor) 是第二代的光敏剂，可用于光动力疗法 (PDT)。
T17035	Temoporfin 替莫卟吩,替莫泊芬	Others	Others
	Temoporfin 能够用于头颈部鳞状细胞癌的光动力学研究。
T7105	Zinc phthalocyanine 酞菁锌,ZnPc	Others	Others
	Zinc phthalocyanine (ZnPc) 可用于环己烷的光氧化，广泛应用于工业 (催化剂、光导体)和生物医学(光动力疗法、PDT)。
TP1535L	GPLGIAGQ acetate GPLGIAGQ acetate(109053-09-0 Free base)	MMP	Proteases/Proteasome
	GPLGIAGQ acetate 是一种 MMP2 可切割的多肽。GPLGIAGQ acetate 可用作脂质体和胶束纳米载体中的刺激敏感接头，以在光动力治疗中合成独特的 MMP2 靶向光敏剂。
T15790	Lucifer Yellow CH dilithium salt
	Lucifer Yellow CH dilithium salt 是一种荧光染料，可常用于选择性染色和研究光动力破坏真核细胞和亚细胞结构。
T3112	Verteporfin 维替泊芬,BPD-MA,CL 318952	Apoptosis; YAP; VDA; Autophagy	Angiogenesis; Apoptosis; Autophagy; Stem Cells
	Verteporfin (BPD-MA) 是一种 YAP 抑制，抑制 YAP-TEAD 相互作用。Verteporfin 也是一种光敏剂，用于光动力疗法。Verteporfin 还可以诱导细胞凋亡，抑制自噬。
T41141	Fullerene-C60 Fullerene-C60
	Fullerene-C60, a carbon nanocompound, is considered a potential agent for photodynamic therapy owing to its distinctive physicochemical properties. It investigates the dynamics of intramolecular electron and energy transfer.
T33761	NT2 Purpurin Purpurin NT 2,NT-2 Purpurin
	NT2 Purpurin is used in photodynamic therapy of induced tumors.
T83486	[Ru(DIP)2TAP]Cl2
	[Ru(DIP)2TAP]Cl2，一种钌(II)聚吡啶基化合物，作为光敏剂，应用于光动力疗法(PDT)的相关研究。
T81028	TBTDC
	TBTDC为具备聚集诱导发射性质的高效多功能有机光敏剂，适用于体内生物成像及光动力学研究。
T16978	Talaporfin sodium ME2906,他拉泊芬钠,NPe6,Mono-L-aspartyl chlorin e6	Others	Others
	Talaporfin is a photosensitizer used in photodynamic therapy.
T34833	TH9402 TH 9402,TH-9402,Xanthylium
	TH9402 is a dibrominated rhodamine derivative and potent photosensitizer and useful in photodynamic therapy. TH9402 eradicates multiple myeloma (MM) and BC cell lines, while sparing more than 50% of normal pluripotential blood stem cells from healthy volu
T19525	PPA-904	Others	Others
	PPA-904 is a specific phenothiazine photosensitizer,and used in photodynamic therapy.
T82998	Antitumor photosensitizer-1
	Antitumor photosensitizer-1（Compound 8）是一种高效的光敏化合物，展现出显著的光动力治疗肿瘤能力，且没有显著的皮肤光毒性反应，是一个潜在的光动力疗法新候选药物。
T40435	Chlorin e6 trimethyl ester 二氢卟吩 e6 三甲酯
	Chlorin e6 trimethyl ester, a derivative of methyl pheophorbide-a, is an effective photosensitizer for photodynamic therapy (PDT).
T40575	ADPM06
	ADPM06, an azadipyrromethene compound, is a new nonporphyrin photodynamic therapeutic (PDT) agent with potential as a lead candidate. It demonstrates significant IC50 values in the micro-molar range in human tumor cells, as well as inducing apoptosis.
T19421	Methyl aminolevulinate	Others	Others
	Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX. Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT).
T80961	TPPC
	TPPC为卟啉胆固醇缀合物，能够提高癌细胞对ICI的敏感性，并增强肺癌光动力免疫治疗效果。
T82997	Antitumor photosensitizer-2
	Antitumor photosensitizer-2（Compound 11）是一款高效光敏剂，表现出显著的光动力学抗肿瘤活性，并且不具有明显的皮肤光毒性，是光动力学治疗领域新药开发的候选物。
T34278	Redaporfin F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11
	Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg
T34053	Phthalocyanine
	Phthalocyanine is an intensely blue-green-coloured aromatic macrocyclic compound that is widely used in dyeing. Phthalocyanine can be used as an agent for Photodynamic Therapy and Imaging. Phthalocyanines form coordination complexes with most elements of
T29922	Aluminum phthalocyanine disulfonate disodium AlPcS2,AlPcS(2a),Disulfonated aluminum phthalocyanine,ClAlPcS2. Clalpcs,AlS2Pc
	Aluminum phthalocyanine disulfonate sodium, also known as AlPcS2 disodium or AlS2Pc or AlPcS(2a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum phthalocyanine disulfonate is
T39127	meso-CF3-BODIPY 2 CF3-substituted Tetramethyl BODIPY,meso-CF3-BODIPY 2
	meso-CF3-BODIPY 2, also known as CF3-substituted Tetramethyl BODIPY, is a fluorescent dye that has an absorption wavelength (λ abs ) of 553 nm and an emission wavelength (λ em ) of 622 nm. This compound is commonly utilized as a labeling reagent and in photodynamic therapy.
T29890	AlPcS4 Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine
	AlPcS4 , also known as aluminum phthalocyanine tetrasulfonate Chloroaluminum tetrasulfophthalocyanine; or AlS4Pc, AlPcS4(a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum pht
T80963	TPEQM-DMA
	TPEQM-DMA为近红外二区光敏剂，能在癌性线粒体中积累，抑制癌细胞生长。其显著I型光疗效果，有助于克服光动力疗法(PDT)治疗低氧肿瘤的限制。
T76055	GPLGIAGQ TFA
	GPLGIAGQ TFA 是一种MMP2可降解 (cleavable) 的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于MMP2触发的肿瘤靶向研究。GPLGIAGQ 可用于合成光动力疗法 (PDT) 中独特的MMP2靶向光敏剂。
T75000	Mal-Pc	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Mal-Pc为基于酞菁和马来酰亚胺设计的多功能分子光敏剂。它能在癌细胞内与GSH反应，耗减GSH并抑制其聚集，进而增强ROS介导的PDT效果。
T34112	Porfimer Sodium DHE,dihematoporphyrin ether,CL184116,CL-184116,CL 184116,Porfimer
	Porfimer sodium is t he sodium salt of a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units with photodynamic activity. Absorbed selectively by tumor cells, porfimer produces oxygen radicals after activation by 630 nm w
T79290	SRE-II	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SRE-II是一种可激活的光敏剂，具有降低的荧光和光敏能力，适用于光动力癌症研究。经羧酸酯酶催化的酰胺键断裂，SRE-II能转化为活性光敏剂SDU Red。在光照射下，SRE-II能诱发DNA损伤和促进细胞凋亡，是治疗三阴性乳腺癌的有希望的诊断试剂。
T34686	Sonoflora 1 SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1
	Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had v
T74962	GLUT1-IN-1
	GLUT1-IN-1 是一种GLUT1 (葡萄糖转运蛋白 1) 抑制剂，显著特异性地失活GLUT1。该化合物对HeLa、A549 及HepG2 细胞线呈现浓度依赖性的细胞毒性，其IC50 值分别为5.49 μM、11.14 μM 与8.73 μM。GLUT1-IN-1 主要应用于光动力疗法（PDT）与癌症研究领域。
T77235	Methylene Violet 3RAX
	Methylene Violet 3RAX 是一种吩嗪染料，用于染色细胞的线粒体。Methylene Violet 3RAX 可以改变DNA 的分子结构，破坏DNA 的模块，诱导活性单线态氧的产生。Methylene Violet 3RAX 对人红细胞AChE 和人血浆BChE 具有抑制作用，Kis 分别为 1.58 和 0.51 μM。Methylene Violet 3RAX 具有研究PDT (光动力疗法) 中线粒体靶向作用的潜在光敏剂的潜力。
T80988	Thymolphthalexon tetrasodium
	Thymolphthalexon (tetrasodium) 是一款应用于生化测定的有机试剂，归属于噻吨酮衍生物，展现出显著的抗氧化特性。该化合物在研究自由基反应、氧化应激以及衰老过程中被广泛应用，并作为光动力疗法的光敏剂，助力癌症与其他疾病治疗。

化合物

Methyl Aminolevulinate Hydrochloride

Cat.No: T5002

Synonym: 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride

Target: Others

8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY

Cat.No: T73590

Cat.No: T15501

Synonym: 光克洛,Photochlor

Target: Others

Cat.No: T17035

Synonym: 替莫卟吩,替莫泊芬

Target: Others

Zinc phthalocyanine

Cat.No: T7105

Synonym: 酞菁锌,ZnPc

Target: Others

GPLGIAGQ acetate

Cat.No: TP1535L

Synonym: GPLGIAGQ acetate(109053-09-0 Free base)

Target: MMP

Lucifer Yellow CH dilithium salt

Cat.No: T15790

Cat.No: T3112

Synonym: 维替泊芬,BPD-MA,CL 318952

Target: Apoptosis, YAP, VDA, Autophagy

Cat.No: T41141

Synonym: Fullerene-C60

Cat.No: T33761

Synonym: Purpurin NT 2,NT-2 Purpurin

[Ru(DIP)2TAP]Cl2

Cat.No: T83486

Cat.No: T81028

Talaporfin sodium

Cat.No: T16978

Synonym: ME2906,他拉泊芬钠,NPe6,Mono-L-aspartyl chlorin e6

Target: Others

Cat.No: T34833

Synonym: TH 9402,TH-9402,Xanthylium

Cat.No: T19525

Target: Others

Antitumor photosensitizer-1

Cat.No: T82998

Chlorin e6 trimethyl ester

Cat.No: T40435

Synonym: 二氢卟吩 e6 三甲酯

Cat.No: T40575

Methyl aminolevulinate

Cat.No: T19421

Target: Others

Cat.No: T80961

Antitumor photosensitizer-2

Cat.No: T82997

Cat.No: T34278

Synonym: F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11

Cat.No: T34053

Aluminum phthalocyanine disulfonate disodium

Cat.No: T29922

Synonym: AlPcS2,AlPcS(2a),Disulfonated aluminum phthalocyanine,ClAlPcS2. Clalpcs,AlS2Pc

meso-CF3-BODIPY 2

Cat.No: T39127

Synonym: CF3-substituted Tetramethyl BODIPY,meso-CF3-BODIPY 2

Cat.No: T29890

Synonym: Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine

Cat.No: T80963

Cat.No: T76055

Cat.No: T75000

Target: Reactive Oxygen Species

Porfimer Sodium

Cat.No: T34112

Synonym: DHE,dihematoporphyrin ether,CL184116,CL-184116,CL 184116,Porfimer

Cat.No: T79290

Target: DNA/RNA Synthesis

Cat.No: T34686

Synonym: SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1

Cat.No: T74962

Methylene Violet 3RAX

Cat.No: T77235

Thymolphthalexon tetrasodium

Cat.No: T80988

Cat. No.	Product Name	Target	Signaling Pathways
T19535	Pyropheophorbide-a Ppa,焦脱镁叶绿酸-ALPHA	Others	Others
	Pyropheophorbide-a (Ppa) 是一种可用于肿瘤光动力疗法 (PDT) 的光敏剂。
T81346	Purpurin 18 methyl ester
	Purpurin 18 methyl ester，一种叶绿素 a 的衍生物，作为光动力疗法(PDT)中的光敏剂，能够诱导癌细胞凋亡。该化合物展现了光动力学活性。
T36430	Pheophorbide a
	Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 μg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells. It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 μg/ml.

天然产物

Pyropheophorbide-a

Cat.No: T19535

Synonym: Ppa,焦脱镁叶绿酸-ALPHA

Target: Others

Purpurin 18 methyl ester

Cat.No: T81346

Cat.No: T36430

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