19
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T25492 |
Hepln-13
Hepln 13,Hepln13 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Hepln-13 是具有口服活性的Hepsin 抑制剂(IC50:0.33 µM)。它可用于研究转移性前列腺癌。 | |||
T17228 |
Sabizabulin
ABI-231,VERU-111 |
Microtubule Associated | Cytoskeletal Signaling |
Sabizabulin (ABI-231) 是一种有效且具有口服生物利用度的 α 和 β 微管蛋白抑制剂,可对抗黑色素瘤和前列腺癌细胞系。 Sabizabulin 通过靶向 HPV E6 和 E7 抑制宫颈癌细胞的肿瘤生长和转移表型。 Sabizabulin 显示出抗增殖活性,可用于前列腺癌研究。 | |||
T73552 |
BPDA2
|
||
BPDA2为高选择性竞争性SHP2活性位点抑制剂,SHP2的IC50为92.0 nM, 对SHP1及SHP1B的IC50则分别为33.39 μM与40.71 μM。该化合物降低了有丝分裂促进因子、细胞存活信号以及RTK的表达,并抑制了SHP2介导的信号传导,影响乳腺癌细胞表型。 | |||
T28138 |
NCDM-32B
NCDM 32B,NCDM32B |
||
NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer. | |||
T34706 |
SRI-29132
SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11 |
||
SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons. | |||
T40950 | A3334 | ||
A3051, is a robust and orally active inhibitor of CXXC5-DVL with an IC 50 of 63.06 nM. Its applications include research into phenotypes associated with obesity, diabetes, and NASH that are induced by high fat diet (HFD) and methionine-choline deficient diet (MCD). | |||
T39586 |
Cantrixil
TRX-E-002-1 |
||
Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes. | |||
T71845 |
Lockdown
|
||
Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F knockout cells. Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F | |||
T70138 | AZ0108 | ||
AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. AZ0108 is more selective in its enzyme inhibition profile and effects on cellular pathways and phenotypes. Specifically, AZ0108 inhibits PARPs 1, 2, and 6 with approxi... | |||
T10607 |
BRD5631
|
Autophagy | Autophagy |
BRD5631 是一种自噬 (autophagy) 增强剂,通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型,包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。BRD5631可以作为一种有价值的工具,用于研究自噬在细胞稳态和疾病中的作用。 | |||
T37745 |
N-pentadecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37737 |
N-cis-octadec-9Z-enoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene... | |||
T37336 |
N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37738 |
N-cis-tetradec-9Z-enoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene... | |||
T37878 |
N-tridecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37879 |
N-undecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37743 |
N-octadecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11219 |
Equisetin
|
Others | Others |
Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and... |