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Cat. No.	Product Name	Target	Signaling Pathways
T15545	ICA-27243	Potassium Channel	Membrane transporter/Ion channel
	ICA-27243 是选择性的，口服有效的 KCNQ2/Q3钾通道开放剂，EC50为 0.38 μM。对 KCNQ4 和 KCNQ3/Q5 的激活效果较差。它具有抗惊厥和抗癫痫作用。
T26086	Rilmakalim	Sodium Channel	Membrane transporter/Ion channel
	Rilmakalim 是一种钾通道开放剂。 Rilmakalim 显示抗血管收缩作用。
T90604	PCO 400
	PCO 400 是一种 comakalim 类似物，可作为一种选择性强的 ATP 敏感型 K+ 通道开放剂。
T7612	ICA 110381	Potassium Channel	Membrane transporter/Ion channel
	ICA 110381 是一种KCNQ2/Q3钾通道开放剂，有潜力用于癫痫的研究。ICA 110381 是KCNQ2/Q3激动剂 (EC50=0.38 μM) 以及KCNQ1拮抗剂 (IC50=15 μM)。
T24786	SG-209
	SG 209是nicorandil的类似物，可作为K+通道开放剂和无硝酸盐的冠状血管扩张剂。
T23563	ZM 226600	Potassium Channel	Membrane transporter/Ion channel
	ZM 226600是一种 ATP 敏感的钾通道开启剂，EC50值是500 nM。ZM226600 对膀胱自发活动有抑制作用。
T4294	NS 11021 NS11021	Potassium Channel	Membrane transporter/Ion channel
	NS 11021 (NS11021) 是特异性 Ca2+激活的大电导 K+(KCa1.1)通道激活剂。当浓度高于0.3 μM 时，它通过平行移动通道激活曲线产生更多负电位，以浓度依赖的方式激活 KCa1.1。
T26086L	1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one	Others	Others
	1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one 是 Rilmakalim 的异构体，Rilmakalim 是一种钾通道打开剂 (PCO)，可以激活心脏或其它组织中 ATP-敏感 K+ 通道
T6504	Flupirtine maleate Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂，可用于缓解疼痛的研究，具有神经保护特性。
T27624	Iptakalim Hydrochloride	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Iptakalim hydrochloride 是一种亲脂性的对氨基化合物，是 ATP 敏感的钾通道的开放剂，也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂，可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。
T16267	Naminidil BMS 234303-01	Others	Others
	Naminidil is an opener of cyanoguanidine KATP.
T17269	Y-27152	Others	Others
	Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763 and is a long-acting K+ channel opener.
T35311	ZM 260384 ZM260384,ZM-260384
	ZM 260384 is a potassium channel opener.
T25102	Aprikalim RP52891,RP-52891,RP 52891
	Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.
T28583	Ro 31-7837 Ro-31-7837,Ro 317837
	Ro 31-7837 is an opener of potassium channel.
T28134	NC00075159 NC 00075159,NC-00075159
	NC00075159 is an opener of human KCNQ4 (Kv7.4) potassium channel.
T13949	U89232	Others	Others
	U-89232 is an opener of the cardioselective KATP channel.
T17094	Tifenazoxide NN414	Others	Others
	Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.
T28195	NS004 NS 004,NS-004
	NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells.
T27718	KCO-912
	KCO-912 is a potent and selective opener of ATP-dependent potassium (K ATP) channels. KCO-912 suppresses airways hyperreactivity at doses devoid of cardiovascular effects.
T30487	BMS 180448 BMS-180448,BMS180448
	BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
T17268	Y-26763	Others	Others
	Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator.
T15667	KRN4884	Others	Others
	KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM).
T28483	QO-58 QO58,QO 58
	QO-58 is a Kv7 channel opener with EC50 values of 7.0, 1.0, 5.2, 0.6 μM for Kv7.1, Kv7.2, Kv7.3/7.5, Kv7.4 respectively. QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo.
T60705	Flupirtine
	Flupirtine(D 9998)是神经元钾通道的选择性开放剂，并且具有NMDA 受体拮抗剂的特性。
T75084	Foslevcromakalim
	Foslevcromakalim (QLS-101 ) 是一种ATP 敏感的钾通道开启剂。Foslevcromakalim 是用于降眼压作用的前体。
T73713	Flupirtine-d4 hydrochloride
	Flupirtine-d4 (D 9998-d4) hydrochloride，Flupirtine (D 9998) hydrochloride的氘代物，为神经元钾通道开放剂，具有拮抗NMDA受体的作用。
T70896	PF05020182
	PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in cont...
T69422	Flupirtine HCl
	Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA re...
T11606	ICA-105665 PF-04895162	Others	Others
	ICA-105665 (PF-04895162) 是一种有效的口服活性的神经元 Kv7.2/7.3和 Kv7.3/7.5钾通道激动剂。ICA-105665 在人肝细胞中具有低细胞毒性潜力，但抑制肝线粒体功能和胆盐输出蛋白 (BSEP) 转运 (IC50为 311 μM)。ICA-105665 可穿透中枢神经系统 (CNS)并具有抗癫痫作用。
T37296	GI-530159
	TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro. Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID...

化合物

Cat.No: T15545

Target: Potassium Channel

Cat.No: T26086

Target: Sodium Channel

Cat.No: T90604

Cat.No: T7612

Target: Potassium Channel

Cat.No: T24786

Cat.No: T23563

Target: Potassium Channel

Cat.No: T4294

Synonym: NS11021

Target: Potassium Channel

1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one

Cat.No: T26086L

Target: Others

Flupirtine maleate

Cat.No: T6504

Synonym: Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀

Target: Potassium Channel, NMDAR, iGluR

Iptakalim Hydrochloride

Cat.No: T27624

Target: Potassium Channel, AChR

Cat.No: T16267

Synonym: BMS 234303-01

Target: Others

Cat.No: T17269

Target: Others

Cat.No: T35311

Synonym: ZM260384,ZM-260384

Cat.No: T25102

Synonym: RP52891,RP-52891,RP 52891

Cat.No: T28583

Synonym: Ro-31-7837,Ro 317837

Cat.No: T28134

Synonym: NC 00075159,NC-00075159

Cat.No: T13949

Target: Others

Cat.No: T17094

Synonym: NN414

Target: Others

Cat.No: T28195

Synonym: NS 004,NS-004

Cat.No: T27718

Cat.No: T30487

Synonym: BMS-180448,BMS180448

Cat.No: T17268

Target: Others

Cat.No: T15667

Target: Others

Cat.No: T28483

Synonym: QO58,QO 58

Cat.No: T60705

Foslevcromakalim

Cat.No: T75084

Flupirtine-d4 hydrochloride

Cat.No: T73713

Cat.No: T70896

Cat.No: T69422

Cat.No: T11606

Synonym: PF-04895162

Target: Others

Cat.No: T37296

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