首页工具

登录

搜索结果

Search Results for " oligomer "

20

抑制剂 & 化合物

10

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T5447	Anle138b	Beta Amyloid; Others	Neuroscience; Others
	Anle138b 是一种毒性低，口服生物利用度高，血脑屏障通透性好的低聚物聚集抑调节剂，可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。
T22012	7BIO	FLT; DYRK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	7BIO 是靛玉红的衍生物，抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。
T6909	NSC348884 N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺	Apoptosis; p53	Apoptosis
	NSC348884 是一种核磷蛋白抑制剂，可破坏寡聚体形成并诱导细胞凋亡，在不同的癌细胞系中以 IC50 为 1.7-4.0 μM 抑制细胞增殖。
T10789	Chitosan oligosaccharide COS,壳聚糖低聚乳酸酯	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chitosan oligosaccharide (COS) 是 β-(1→4)-连接的 D-氨基葡萄糖的寡聚体，Chitosan oligosaccharide可激活 AMPK ，抑制NF-κB 和 MAPK在内的炎症信号通路。
T12532	PQM130	Beta Amyloid	Neuroscience
	PQM130是一种魏罗酮-多奈哌齐杂化化合物，能透过大脑。PQM130是多靶点的候选药物，可用于Aβ1-42低聚物引起的神经毒性，还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。
T14199	ALZ-801 Valiltramiprosate	Beta Amyloid	Neuroscience
	ALZ-801 是一种可口服的小分子 β-淀粉样蛋白抗寡聚体和聚集抑制剂，是曲米酸的缬氨酸偶联前药，与母体化合物相比，具有显著改善的 PK 特性和胃肠道耐受性。它是治疗阿尔茨海默病的先进且显著改善的候选药物。
T38860	Golodirsen Golodirsen,SRP-4053
	Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) designed to selectively bind and target exon 53 of dystrophin pre-mRNA, with applications in the investigation of Duchenne muscular dystrophy (DMD).
T24779	SEN-1269
	SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo.
T34418	RS-0406 RS0406,Phenol
	RS-0406 is a new type of β-flakes blocker, which can reverse amyloid β-induced cytotoxicity and long-term enhanced damage in vitro, and inhibit amyloid-oligomer-induced behavior deterioration in vivo.
T21097	Decamethyltetrasiloxane Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780
	Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to other organic compounds.
T38859	Casimersen SRP-4045
	Casimersen (SRP-4045) is an antisense oligonucleotide, specifically belonging to the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, effectively restoring the open-reading frame by skipping exon 45. This action ultimately leads to the production of a functional dystrophin protein, albeit internally truncated. Casimersen finds utility in Duchenne muscular dystrophy (DMD) research.
T83173	Activated T Subunit
	Activated T Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。该寡聚物偶联物与人类抗肌萎缩蛋白基因中选定靶位点互补，适用于肌肉萎缩症研究。
T83175	Activated DPG Subunit
	Activated DPG Subunit 用于合成可诱导外显子 51 跳跃的外显子跳跃寡聚物偶联物。这些偶联物与人抗肌萎缩蛋白基因中选定的靶位点互补，有助于肌肉萎缩症的研究。
T81912	LSP-GR3	iGluR	Membrane transporter/Ion channel; Neuroscience
	LSP-GR3为一种新型化学修饰RNA寡核苷酸，亦即剪接调控寡聚体(SMOs)，可特异性调控中枢神经系统内GluR的选择性剪接及GluR3-flip表达。
T81693	NCP2 Anchor
	NCP2 Anchor用于合成外显子跳跃寡聚物偶联物。它的偶联物与人抗肌萎缩蛋白基因特定靶位点配对互补，从而诱导外显子52的跳跃。该偶联物常应用于肌肉萎缩症的科学研究。
T71855	Z640
	Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from amyloid‑β (Aβ) oligomer‑induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose‑dependent manner and shift amyloid precursor protein processing towards the non‑amyloid pathway
T83176	Activated C Subunit
	Activated C Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。所得寡聚物偶联物与人类抗肌萎缩蛋白基因特定靶位点互补，有助于研究肌肉萎缩症。
T76395	(Met(O)35)-Amyloid β-Protein (1-42)
	'(Met(O)35)-Amyloid β-Protein (1-42)，Aβ42的一种氧化形态，位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体，适用于阿尔茨海默病（AD）研究。'
T83177	Activated A Subunit
	Activated A Subunit 适用于合成促进外显子跳跃的寡聚物偶联体。所合成的偶联体与人类抗肌萎缩蛋白基因内特定的序列配对互补，能够有效促进外显子51的跳跃，为肌萎缩疾病研究提供了一种工具。
T83174	Activated EG3 Tail
	Activated EG3 Tail 适用于合成外显子跳跃寡聚物偶联物。该寡聚物偶联物能与人类抗肌萎缩蛋白基因特定的靶位点匹配，进而诱导外显子 51 的跳跃。此类偶联物对于肌肉萎缩症研究具有重要价值。

化合物

Cat.No: T5447

Target: Beta Amyloid, Others

Cat.No: T22012

Target: FLT, DYRK, Aurora Kinase

Cat.No: T6909

Synonym: N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺

Target: Apoptosis, p53

Chitosan oligosaccharide

Cat.No: T10789

Synonym: COS,壳聚糖低聚乳酸酯

Target: AMPK

Cat.No: T12532

Target: Beta Amyloid

Cat.No: T14199

Synonym: Valiltramiprosate

Target: Beta Amyloid

Cat.No: T38860

Synonym: Golodirsen,SRP-4053

Cat.No: T24779

Cat.No: T34418

Synonym: RS0406,Phenol

Decamethyltetrasiloxane

Cat.No: T21097

Synonym: Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780

Cat.No: T38859

Synonym: SRP-4045

Activated T Subunit

Cat.No: T83173

Activated DPG Subunit

Cat.No: T83175

Cat.No: T81912

Target: iGluR

Cat.No: T81693

Cat.No: T71855

Activated C Subunit

Cat.No: T83176

(Met(O)35)-Amyloid β-Protein (1-42)

Cat.No: T76395

Activated A Subunit

Cat.No: T83177

Activated EG3 Tail

Cat.No: T83174

Cat. No.	Product Name	Target	Signaling Pathways
T5650	2,2':5',2''-Terthiophene alpha-三联噻吩,α-Terthienyl,Trithiophene	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	2,2':5',2''-Terthiophene (Trithiophene) 是杂环噻吩的低聚物，可用作有机合成的砌块。
T2S0633	Raspberry ketone Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮	PPAR	DNA Damage/DNA Repair; Metabolism
	Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物，主要用作化妆品的香料和食品增味剂，也可作 PPAR-α激动剂。
T38555	Chitotetraose tetrahydrochloride
	Chitotetraose tetrahydrochloride is a short-chain chitin oligomer derived from arbuscular mycorrhizal (AM) fungi. This compound effectively activates the conserved symbiosis signaling pathway (CSSP) in actinorhizal plant species.
T40967	D-Octamannuronic acid
	D-Octamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram-negative bacteria. It is research-oriented for the study of pain and vascular dementia [4].
T38981	D-Tetramannuronic acid
	D-Tetramannuronic acid, an alginate oligomer, is derived from marine brown algae and certain Gram negative bacteria. It serves as a valuable compound for pain and vascular dementia research[4].
T39277	D-Hexamannuronic acid
	D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4].
T39276	D-Pentamannuronic acid
	D-Pentamannuronic acid is an alginate oligomer, synthesized by marine brown algae and a select group of Gram-negative bacteria. This chemical compound is valuable for research related to pain and vascular dementia[4].
T40966	D-Heptamannuronic acid
	D-Heptamannuronic acid, an alginate oligomer, is derived from marine brown algae and a select group of Gram-negative bacteria. This compound serves as a valuable research tool in the study of pain and vascular dementia[4].
T35614	D-Trimannuronic acid
	D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].
T82535	D-Nonamannuronic acid
	D-Nonamannuronic acid 是海洋褐藻及部分革兰氏阴性细菌产生的藻酸盐低聚物。该化合物用于疼痛与血管性痴呆的研究应用。

天然产物

2,2':5',2''-Terthiophene

Cat.No: T5650

Synonym: alpha-三联噻吩,α-Terthienyl,Trithiophene

Target: Others, Antibacterial, Antibiotic

Raspberry ketone

Cat.No: T2S0633

Synonym: Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮

Target: PPAR

Chitotetraose tetrahydrochloride

Cat.No: T38555

D-Octamannuronic acid

Cat.No: T40967

D-Tetramannuronic acid

Cat.No: T38981

D-Hexamannuronic acid

Cat.No: T39277

D-Pentamannuronic acid

Cat.No: T39276

D-Heptamannuronic acid

Cat.No: T40966

D-Trimannuronic acid

Cat.No: T35614

D-Nonamannuronic acid

Cat.No: T82535

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼