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30

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14049	5-FAM SE	Others	Others
	5-FAM SE 是单一异构体，是用于标记肽、蛋白质和核苷酸的荧光标记试剂。它能够与胺反应，产生稳定的胺结合物。
T7092	NADPH tetrasodium salt	Others; Ferroptosis; Endogenous Metabolite	Apoptosis; Metabolism; Others
	NADPH tetrasodium salt 是电子受体烟酰胺腺嘌呤二核苷酸磷酸的还原形式，在各种生物反应中充当电子供体。NADPH tetrasodium salt 也是一种内源性铁死亡抑制剂。
T18901	6-FAM SE 6-羧基荧光素琥珀酰亚胺醚,6-Carboxyfluorescein N-succinimidyl ester	Others	Others
	6-FAM SE (6-Carboxyfluorescein N-succinimidyl ester) 是羧基荧光素的同分异构体，常用于核酸测序和标记核苷酸。
T4057	Hoechst 33258 trihydrochloride Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258	Parasite	Microbiology/Virology
	Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。
T10509	Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-1是一种有效的黄嘌呤氧化酶抑制剂(IC50值:6.5 nM),是一种利用核酸和核苷酸介质降解产生的生物活性核苷酸在嘌呤分解代谢中起核心作用的化合物，
T77194L	D-Ribose 5-phosphate disodium dihydrate
	D-Ribose 5-phosphate disodium dihydrate 是戊糖磷酸途径 (PPP) 氧化分支的中间产物，是 PPP 非氧化分支的终产物。D-Ribose 5-phosphate 用于核苷酸和核酸的合成。
T40192	dGTP 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dGTP（2'-Deoxyguanosine-5'-triphosphate）作为脱氧核糖核酸（DNA）合成的基本单元，属于鸟苷核苷酸，对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T61860	Enpp-1-IN-9
	Enpp-1-IN-9, a powerful inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1), exhibits wide substrate specificity, capable of cleaving various bonds such as phosphodiester bonds of nucleotides and nucleotide sugars, as well as pyrophosphate bonds of nucleotides and nucleotide sugars. Its potential application lies in the fields of cancer and infectious disease research[1].
T25324	Dichloromethotrexate NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630
	Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver.
T62085	Enpp-1-IN-5
	Enpp-1-IN-5 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。ENPP 1 显示出广泛的特异性，能够切割多种底物（包括核苷酸和核苷酸糖的磷酸二酯键、核苷酸和核苷酸糖的焦磷酸键）。 Enpp-1-IN-5 具有潜力进行癌症和传染病的研究。
T62368	Enpp-1-IN-7
	Enpp-1-IN-7 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。ENPP 1 具有广泛的特异性，能够切割多种底物（包括核苷酸和核苷酸糖的磷酸二酯键以及核苷酸和核苷酸糖的焦磷酸键）。 Enpp-1-IN-7 具有潜力进行癌症和传染病的研究。
T37895	4-Nitrophenyl Phenylphosphonate
	4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterases. It is a more preferable substrate to 5'-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.
TD0075	7-Hydroxy-4-methylcoumarin-3-acetic acid
	7-Hydroxy-4-methylcoumarin-3-acetic acid is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. This coumarin is increasingly used to label peptides, nucleotides and carbohydrates.
TD0074	N-Succinimidyl 7-hydroxycoumarin-3-carboxylate 7-羟基-3-羧基香豆素琥珀酰亚胺酯,7-Hydroxycoumarin-3-carboxylic acid, succinimidyl ester
	7-Hydroxycoumarin-3-carboxylic acid, SE is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. This coumarin is also increasingly used to label peptides, nucleotides and carbohydrates.
TNU1204	3’-Azido-2’,3’-dideoxyuridine 5’-phosphate diammonium salt
	Nucleoside Derivatives - Phosphorus-containing nucleotides, Azido-nucleosides, 2’,3’-Dideoxy-nucleosides
TD0031	Cy3 diacid 脂性Cy3双酸
	Cy3 diacid is often used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.They are widely used in polypeptides, proteins, nucleotides and so on.
TD0032	Cy3 diacid, SE 脂性Cy3双酸-N-羟基琥珀酰亚胺酯
	Cy3 diacid, SE is often used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.They are widely used in polypeptides, proteins, nucleotides and so on.
T76214	5′-Nucleotidase
	5′-Nucleotidase (CD73) 是一种作为胞外酶存在的内在膜糖蛋白。5′-Nucleotidase 催化 5-核苷酸水解成相应的核苷。
T35703	2-hydroxy Stearic Acid methyl ester
	2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
T38472	Phosphoribosyl pyrophosphate pentasodium PRPPpentasodium,磷酸核糖焦磷酸
	Phosphoribosyl pyrophosphate (PRPP) pentasodium is a vital metabolite essential for the biosynthesis of purine and pyrimidine nucleotides, as well as the amino acids histidine and tryptophan. It also acts as a precursor for the important cofactors NAD and NADP.
T40753	Cytidine-5'-triphosphate Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP
	Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is synthesized through the catalytic action of cytidine triphosphate synthase, which converts uridine 5'-triphosphate (UTP) to cytidine 5'-triphosphate. Cytidine 5'-triphosphate is an essential biomolecule in T. gondii's de novo pyrimidine biosynthetic pathway.
T76138	Phosphodiesterase
	Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶，常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根据其对环核苷酸的特异性也可以分别不同类型，如 PDE1-PDE11，在多种疾病方面也具有一定的潜力。
T62459	Enpp-1-IN-8
	Enpp-1-IN-8 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。其中 ENPP 1 具有广泛特异性，能够切割多种底物（包括核苷酸和核苷酸糖的磷酸二酯键以及核苷酸和核苷酸糖的焦磷酸键）。 Enpp-1-IN-8 具有潜力进行癌症和传染病的研究。
T73930	(-)-Eseroline fumarate
	(-)-Eseroline fumarate 是一种 AChE 抑制剂 Physostigmine 的代谢产物。(-)-Eseroline fumarate 引起癌细胞的乳酸脱氢酶 (LDH) 泄漏。(-)-Eseroline fumarate 还诱导神经元细胞释放腺嘌呤核苷酸和5-羟色胺 (5-HT)，从而诱导细胞死亡。(-)-Eseroline fumarate 抑制小鼠输精管和豚鼠回肠的电诱发抽搐。
T63246	BMS-566419
	BMS-566419 是基于吖啶酮的肌苷 5'-一磷酸脱氢酶 (IMPDH) 抑制剂。其中肌苷一磷酸脱氢酶 (IMPDH) 是一种鸟苷核苷酸从头合成的关键酶。BMS-566419 在临床上具有研究移植排斥的实用性。
T74693	CDN-A
	CDN-A为一种环二核苷酸，主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂，环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成，在人体内通过促进干扰素基因表达激活先天免疫系统。
T63985	Trimetrexate glucuronate
	Trimetrexate glucuronate (NSC 352122) 是一种叶酸拮抗剂，能够抑制二氢叶酸还原酶 (dihydrofolate reductase)，进而阻断嘌呤核苷酸和胸苷酸的合成，影响 DNA 和 RNA 合成，表现出潜在的抗肿瘤效果。
T35575	Aldehyde Reactive Probe (trifluoroacetate salt)
	DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-...
T35572	Adenosine 3',5'-diphosphate sodium salt 3'-Phosphoadenosine 5'-phosphate	Endogenous Metabolite	Metabolism
	Adenosine 3',5'-diphosphate sodium salt 是一种羟类固醇磺基转移酶 (hydroxysteroid sulfotransferases) 抑制剂，是一种腺嘌呤核苷酸，在戊糖核糖的 3'和 5'位置含有一个磷酸基团。Adenosine 3',5'-diphosphate (sodium salt)是 3'-phosphoadenosine 5'-phosphosulfonate (PAPS) 的产物，是磺基转移酶（SULTs）的辅助因子，已被用于研究 SULTs 的动力学特性和结构。
T35573	Adenosine 5’-methylenediphosphate (hydrate)
	Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ...

化合物

Cat.No: T14049

Target: Others

NADPH tetrasodium salt

Cat.No: T7092

Target: Others, Ferroptosis, Endogenous Metabolite

Cat.No: T18901

Synonym: 6-羧基荧光素琥珀酰亚胺醚,6-Carboxyfluorescein N-succinimidyl ester

Target: Others

Hoechst 33258 trihydrochloride

Cat.No: T4057

Synonym: Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258

Target: Parasite

Xanthine oxidase-IN-1

Cat.No: T10509

Synonym: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid

Target: Xanthine Oxidase

D-Ribose 5-phosphate disodium dihydrate

Cat.No: T77194L

Cat.No: T40192

Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T61860

Dichloromethotrexate

Cat.No: T25324

Synonym: NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630

Cat.No: T62085

Cat.No: T62368

4-Nitrophenyl Phenylphosphonate

Cat.No: T37895

7-Hydroxy-4-methylcoumarin-3-acetic acid

Cat.No: TD0075

N-Succinimidyl 7-hydroxycoumarin-3-carboxylate

Cat.No: TD0074

Synonym: 7-羟基-3-羧基香豆素琥珀酰亚胺酯,7-Hydroxycoumarin-3-carboxylic acid, succinimidyl ester

3’-Azido-2’,3’-dideoxyuridine 5’-phosphate diammonium salt

Cat.No: TNU1204

Cat.No: TD0031

Synonym: 脂性Cy3双酸

Cat.No: TD0032

Synonym: 脂性Cy3双酸-N-羟基琥珀酰亚胺酯

5′-Nucleotidase

Cat.No: T76214

2-hydroxy Stearic Acid methyl ester

Cat.No: T35703

Phosphoribosyl pyrophosphate pentasodium

Cat.No: T38472

Synonym: PRPPpentasodium,磷酸核糖焦磷酸

Cytidine-5'-triphosphate

Cat.No: T40753

Synonym: Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP

Phosphodiesterase

Cat.No: T76138

Cat.No: T62459

(-)-Eseroline fumarate

Cat.No: T73930

Cat.No: T63246

Cat.No: T74693

Trimetrexate glucuronate

Cat.No: T63985

Aldehyde Reactive Probe (trifluoroacetate salt)

Cat.No: T35575

Adenosine 3',5'-diphosphate sodium salt

Cat.No: T35572

Synonym: 3'-Phosphoadenosine 5'-phosphate

Target: Endogenous Metabolite

Adenosine 5’-methylenediphosphate (hydrate)

Cat.No: T35573

Cat. No.	Product Name	Target	Signaling Pathways
T0746	Orotic acid 乳清酸,Vitamin B13,6-Carboxyuracil	Nucleoside Antimetabolite/Analog; Dehydrogenase; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Orotic acid (Vitamin B13) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
T3271	Orotic acid zinc 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate	Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Orotic acid zinc (Zinc Orotate) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
T2A2537	Guanine 鸟嘌呤;2-氨基次黄嘌呤;2-氨基-6-羟基嘌呤;鸟便嘌呤;鸟粪素;海鸟粪碱;鸟粪环;亚氨基二氧化嘌呤,Pearl essence,Mearlmaid,鸟嘌呤,2-Aminohypoxanthine	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Guanine (2-Aminohypoxanthine) 是一种嘌呤碱基，是核酸中核苷酸的组成部分，由具有共轭双键的稠合嘧啶 - 咪唑环系统组成。
T3S0156	Atractyloside potassium salt Atractyloside Dipotassium Salt,苍术苷钾盐,苍术苷二钾盐	Others	Others
	Atractyloside potassium salt (Atractyloside Dipotassium Salt) 是一种从苍术果实中分离出得到的二萜苷类化合物，具有毒性。它能抑制大鼠心脏线粒体膜的氯离子通道。它是高效、特异性的线粒体 ADP/ATP 转运 (ADP/ATP transport) 抑制剂。
TMA2440	Uridine 5'-monophosphate disodium salt 尿苷-5'-单磷酸二钠盐,Disodium UMP,尿苷酸二钠盐,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate	Others	Others
	Uridine 5'-monophosphate disodium salt (Disodium UMP) 是合成 RNA 的一种重要成分。
T1705	5-Amino-3H-imidazole-4-Carboxamide 4-Amino-5-imidazolecarboxamide,AICA,4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide	Endogenous Metabolite	Metabolism
	5-Amino-3H-imidazole-4-Carboxamide (AICA) 是一种合成嘌呤（尤其是核碱基腺嘌呤和鸟嘌呤）的重要前体。
T2O2731	L-Aspartic acid L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Aspartic acid (Aspatofort) 是一种氨基酸，是结肠特异性药物输送的前体药物。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。
T4758	2'-Deoxycytidine Cytosine deoxyribonucleoside,2'-Deoxycytidine monohydrate,2(1H)-Pyrimidinone,Cytosine deoxyriboside,Deoxyribose cytidine,Deoxycytidine,2'-脱氧胞嘧啶核苷一水合物	Endogenous Metabolite	Metabolism
	2'-Deoxycytidine (Deoxyribose cytidine) 是由胞嘧啶和脱氧核糖组成的DNA的主要核苷之一。核苷仅由与嘌呤或嘧啶碱相连的戊糖组成，没有磷酸基团。当N1与脱氧核糖的C1连接时，由胞嘧啶和脱氧核糖形成脱氧核苷和核苷酸；脱氧胞苷单磷酸(dCMP)，脱氧胞苷二磷酸(dCDP)，脱氧胞苷三磷酸(dCTP)。CTP是RNA(核糖核酸)中胞苷的来源，脱氧胞苷三磷酸(dCTP)是DNA(脱氧核糖核酸)中脱氧胞苷的来源。
T19267	D-Ribose 5-phosphate	Others	Others
	Ribose 5-phosphate is the intermediate product of the oxidative branch of the pentose phosphate pathway (PPP) and the final product of the non-oxidative branch of PPP. Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.

天然产物

Cat.No: T0746

Synonym: 乳清酸,Vitamin B13,6-Carboxyuracil

Target: Nucleoside Antimetabolite/Analog, Dehydrogenase, Endogenous Metabolite

Orotic acid zinc

Cat.No: T3271

Synonym: 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Cat.No: T2A2537

Synonym: 鸟嘌呤;2-氨基次黄嘌呤;2-氨基-6-羟基嘌呤;鸟便嘌呤;鸟粪素;海鸟粪碱;鸟粪环;亚氨基二氧化嘌呤,Pearl essence,Mearlmaid,鸟嘌呤,2-Aminohypoxanthine

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Atractyloside potassium salt

Cat.No: T3S0156

Synonym: Atractyloside Dipotassium Salt,苍术苷钾盐,苍术苷二钾盐

Target: Others

Uridine 5'-monophosphate disodium salt

Cat.No: TMA2440

Synonym: 尿苷-5'-单磷酸二钠盐,Disodium UMP,尿苷酸二钠盐,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate

Target: Others

5-Amino-3H-imidazole-4-Carboxamide

Cat.No: T1705

Synonym: 4-Amino-5-imidazolecarboxamide,AICA,4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide

Target: Endogenous Metabolite

L-Aspartic acid

Cat.No: T2O2731

Synonym: L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid

Target: Others, Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

2'-Deoxycytidine

Cat.No: T4758

Synonym: Cytosine deoxyribonucleoside,2'-Deoxycytidine monohydrate,2(1H)-Pyrimidinone,Cytosine deoxyriboside,Deoxyribose cytidine,Deoxycytidine,2'-脱氧胞嘧啶核苷一水合物

Target: Endogenous Metabolite

D-Ribose 5-phosphate

Cat.No: T19267

Target: Others

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