首页工具

登录

搜索结果

Search Results for " neuronal nicotinic receptors "

21

抑制剂 & 化合物

3

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9787	suvn-911	AChR	Neuroscience
	SUVN-911 是高选择性的，大脑通透性的和口服有效的神经元烟碱乙酰胆碱 α4β2 受体拮抗剂，Ki 为 1.5 nM。SUVN-911显示出抗抑郁作用。
T60080	TMPH 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR	Neuroscience
	TMPH 是一种 nAChR 抑制剂，可抑制缺乏 α5、α6 或 β3 亚基的 nAChR。 TMPH 可用于关于 nAChR 功能障碍或神经系统疾病的研究。
T2285	Encenicline hydrochloride (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐,EVP-6124 (hydrochloride),EVP-6124 hydrochloride	AChR	Neuroscience
	Encenicline hydrochloride (EVP-6124 hydrochloride) 是一种新型的α7神经元烟碱乙酰胆碱受体激动剂。
T7884	NS 1738 NSC 213859	AChR	Neuroscience
	NS 1738 (NSC-213859) 是含有 α7 的神经元烟碱乙酰胆碱受体 (nAChRs) 的正变构调节剂。在卵母细胞实验中，正调节 α7nAChR，EC50为 3.4 μM。
TP2063	α-Conotoxin MII	AChR	Neuroscience
	α-Conotoxin MII 是可从僧袍芋螺中分离得到的一种天然产物，有效抑制 nAChR 受体的α3β2亚基，IC50值为 0.5 nM。它还可有效抑制 β3-containing 神经尼古丁受体。
T22735	DMAB-anabaseine dihydrochloride N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride	AChR	Neuroscience
	DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) 是一种含有 α7 的神经元烟碱受体部分激动剂和 α4β2 和其他烟碱受体的拮抗剂。
TP2063L	α-Conotoxin MII acetate α-Conotoxin MII acetate (175735-93-0 Free base)	AChR	Neuroscience
	α-Conotoxin MII acetate 是一种来自海洋蜗牛 Conus magus 毒液的 16 个氨基酸肽。它有效阻断由 α3β2 亚基组成的烟碱型乙酰胆碱受体，IC50 为 0.5 nM。它可有效阻断含 β3 的神经元烟碱乙酰胆碱受体。
T29916	Altinicline
	Altinicline can bine with neuronal nicotinic acetylcholine receptors; SIB-1765F - fumarate.
T16281	Nelonicline ABT-126	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Nelonicline is a selective agonist of neuronal nicotinic receptors.
T23462	TMPH hydrochloride	Others	Others
	neuronal nicotinic ACh receptors (nAChRs) antagonist
T12738L	Rivanicline RJR-2403,(E)-Metanicotine	Others	Others
	Rivanicline is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). It show > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM and IC50 : 26 nM).
T22401	PNU-282987 S enantiomer hydrochloride (S)-PNU-282987 HCl	Others	Others
	(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible activity against α1β1γδ and α3β4 nAC
T23235	RJR-2403 hemioxalate	Others	Others
	RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). RJR-2403 hemioxalate > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).
T80466	κ-Bungarotoxin κ-Bgt
	κ-Bungarotoxin (κ-Bgt) 是高效、特异性且缓慢可逆性α3β2神经元烟碱型乙酰胆碱受体(nAChR)拮抗剂，其IC50值为 2.30 nM。
T75927	α-Conotoxin MII TFA
	α-Conotoxin MII TFA (α-CTxMII TFA) 是可从海螺 Conus magus 中分离得到，有效抑制 nAChR 受体的α3β2亚基，其 IC50值为 0.5 nM。α-Conotoxin MII TFA (α-CTxMII TFA) 可有效抑制 β3-containing 神经尼古丁受体。
T80481	α-Conotoxin Bt1.8
	α-Conotoxin Bt1.8是针对α6/α3β2β3和α3β2nAChRs的高效抑制剂，其对大鼠α6/α3β2β3和α3β2的IC50值分别为2.1nM和9.4nM。
T3694L	Tebanicline tosylate
	Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent analgesic activity against neuropat
T80338	RVG Rabies Virus Glycoprotein-29,RVG29,RDP
	RVG (RVG29) 是从狂犬病病毒糖蛋白衍生的肽，它能够结合到神经元细胞的烟碱乙酰胆碱受体 (AchR) α-7 亚基上。此外，RVG 促进了结核分枝杆菌抗原向抗原呈递细胞的递送效率。
T80482	α-Conotoxin EIIB Alpha-conotoxin EIIB
	α-Conotoxin EIIB（Alpha-conotoxin EIIB）是从芋螺（Conus ermineus）毒液中提取的一种肽类毒素，具有与nAChR结合的能力（Ki=2.2 nM）。该毒素肽在神经性疾病（包括精神分裂症、药物成瘾、阿尔茨海默病以及帕金森病）的研究中有应用。
T37202	CC4 CC4
	High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 ...
T12738	Rivanicline hemioxalate RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate	Others	Others
	Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性(Ki= 26 nM)，比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。

化合物

Cat.No: T9787

Target: AChR

Cat.No: T60080

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Target: AChR

Encenicline hydrochloride

Cat.No: T2285

Synonym: (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐,EVP-6124 (hydrochloride),EVP-6124 hydrochloride

Target: AChR

Cat.No: T7884

Synonym: NSC 213859

Target: AChR

α-Conotoxin MII

Cat.No: TP2063

Target: AChR

DMAB-anabaseine dihydrochloride

Cat.No: T22735

Synonym: N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride

Target: AChR

α-Conotoxin MII acetate

Cat.No: TP2063L

Synonym: α-Conotoxin MII acetate (175735-93-0 Free base)

Target: AChR

Cat.No: T29916

Cat.No: T16281

Synonym: ABT-126

Target: Adenosine Receptor

TMPH hydrochloride

Cat.No: T23462

Target: Others

Cat.No: T12738L

Synonym: RJR-2403,(E)-Metanicotine

Target: Others

PNU-282987 S enantiomer hydrochloride

Cat.No: T22401

Synonym: (S)-PNU-282987 HCl

Target: Others

RJR-2403 hemioxalate

Cat.No: T23235

Target: Others

κ-Bungarotoxin

Cat.No: T80466

Synonym: κ-Bgt

α-Conotoxin MII TFA

Cat.No: T75927

α-Conotoxin Bt1.8

Cat.No: T80481

Tebanicline tosylate

Cat.No: T3694L

Cat.No: T80338

Synonym: Rabies Virus Glycoprotein-29,RVG29,RDP

α-Conotoxin EIIB

Cat.No: T80482

Synonym: Alpha-conotoxin EIIB

Cat.No: T37202

Synonym: CC4

Rivanicline hemioxalate

Cat.No: T12738

Synonym: RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T9076	Spinosad	Others	Others
	Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂，是大环内酯多杀菌素 A 和多杀菌素 D 的混合物，可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征，以及杀灭幼虫的活性。
T0086	Galanthamine hydrobromide Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏	AChR; AChE	Neuroscience
	Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂，IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂，IC50值为 0.35 µM，可用于阿尔茨海默症的研究。
T11041	Dihydro-β-erythroidine hydrobromide DHβE hydrobromide	Others	Others
	Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAChR, with IC50 of 0.19 and 0.37 μM,

天然产物

Cat.No: T9076

Target: Others

Galanthamine hydrobromide

Cat.No: T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏

Target: AChR, AChE

Dihydro-β-erythroidine hydrobromide

Cat.No: T11041

Synonym: DHβE hydrobromide

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼