Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T25859 |
Necrostatin-7
Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 |
Apoptosis | Apoptosis |
Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂,具有心脏保护作用,可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。 | |||
T1847 |
Necrostatin-1
Nec-1,Necrostatin 1 |
Indoleamine 2,3-Dioxygenase (IDO); Ferroptosis; Autophagy; RIP kinase | Apoptosis; Autophagy; Metabolism; NF-κB |
Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂,具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。 | |||
T7504 |
Necrostatin 2 racemate
5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate |
RIP kinase | Apoptosis; NF-κB |
Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂,是一种稳定型 Nec-1。 | |||
T9095 |
Necrostatin-34
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
RIP kinase | Apoptosis; NF-κB |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂,通过在激酶结构域中占据一个独特的结合口袋,将 RIPK1 激酶稳定在非活性构象中。 | |||
T37558 |
Necrostatin-5
Nec-5 |
RIP kinase; Necroptosis | Apoptosis; NF-κB |
Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂,也是一种细胞坏死抑制剂,可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡,EC50值为240 nM。 | |||
T12203L |
Necrostatin 2
|
Others | Others |
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. | |||
T68520 |
Cl-Necrostatin-1
|
||
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity. | |||
T12203 | Necrostatin 2 S enantiomer | Others | Others |
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 | |||
T8468 |
CIL62
|
Caspase | Apoptosis; Proteases/Proteasome |
CIL62 是一种不依赖 caspase-3/7 的细胞死亡诱导剂。CIL62的作用机制是 Necrostatin-1 依赖性细胞死亡。 | |||
T9305 |
Necroptosis-IN-1
|
RIP kinase | Apoptosis; NF-κB |
Necroptosis-IN-1 是一种 RIPK1 坏死性凋亡抑制剂。 它是 Necrostatin-1 的类似物。 | |||
T73521 | Nec-3a | ||
Nec-3a,一种Necrostatin-3类似物,作为RIP1抑制剂(IC50: 0.44 μM),能够抑制RIP1激酶结构域的自磷酸化活性。 |