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Search Results for " mycobacteria "

24

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14830	Bromperidol 溴哌利多,R-11333	5-HT Receptor	GPCR/G Protein; Neuroscience
	Bromperidol (R-11333) 是一种苯丁酮衍生物，是一种强效长效精神安定药。它被用作治疗精神分裂症的抗精神病药。
T0972	Isoniazid INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide	Mitophagy; Dehydrogenase; CAT; Antibacterial; Autophagy	Autophagy; Metabolism; Microbiology/Virology; oxidation-reduction
	Isoniazid (Isonicotinic hydrazide) 是一种必须被细菌过氧化氢酶 KatG 激活的前药，具有抗菌活性。它对快速分裂的分枝杆菌具有杀菌作用。
T60073	Antimycobacterial agent-4 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide	Antibacterial	Microbiology/Virology
	Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) 对结核分枝杆菌具有抗菌活性。
T63865	Antimycobacterial agent-3
	Antimycobacterial agent-3 是一种抗分枝杆菌 (antimycobacterial) 剂，细胞毒性较低。Antimycobacterial agent-3 能够有效作用于药敏的 MTB 菌株 H37Rv 和耐药的临床分离株 (MIC< 0.029-0.110 μM)。
T61853	Antimycobacterial agent-1
	Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial agent-1 exhibits low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells [1].
T72306	Mycobacterial Zmp1-IN-1
	Mycobacterial Zmp1-IN-1 是一种分枝杆菌锌金属蛋白酶-1(Zmp1)抑制剂。Mycobacterial Zmp1-IN-1 对 MtbH37Ra 具有剂量依赖性抑制的抗分枝杆菌活性。Mycobacterial Zmp1-IN-1 可用于结核病 (TB) 的研究。
T79281	Antimycobacterial agent-6
	Antimycobacterial agent-6 (compound 25) 是抗结核药物，针对野生型及氟喹诺酮耐药的结核分枝杆菌 (Mtb) 株有效。此化合物对 Mtb DprE1-C387S 突变具有抑制作用，其最小抑菌浓度（MIC90）对 H37Rv 和 MoxR 株均为 0.9 μM，对 DprE1-P116S 株为 0.5 μM。
T63420	Antimycobacterial agent-2
	Antimycobacterial agent-2 是有效的抗分枝杆菌剂，对结核分枝杆菌 (M.tb) H37Rv 的MIC99为 0.8 μM。Antimycobacterial agent-2 具有出细胞毒作用，能够作用于 CHO 细胞 (IC50: 48.1 μM)。
T0377	Clofazimine NSC-141046,氯法齐明,氯苯吩嗪	DNA; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Clofazimine (NSC-141046) 是一种具有显著的抗炎效果的亚氨基酚嗪类染料，与其它抗分支杆菌药物联用来治疗AIDS 和克罗恩病。
T21023	Bedaquiline fumarate TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline fumarate (TMC207) 是二芳基喹啉抗生素，作用于 ATP 合成酶，常用于结核杆菌感染的研究。
T7518	Deoxycytidine triphosphate trisodium salt 2'-脱氧胞苷-5'-三磷酸三钠盐,2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) 是可用于 DNA 合成的核苷三磷酸，可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。
T23979	Deoxypheganomycin D
	Deoxypheganomycin D is a specific mycobacteria inhibitor.
T26189	Setomimycin AM 2947,Antibiotic A 39183B,AM2947,AM-2947
	Setomimycin is an antibiotic against Gram positive bacteria, including mycobacteria.
T60486	Mycobactin-IN-1
	Mycobactin-IN-1 (compound 44) 是一种吡唑啉类似物。Mycobactin-IN-1 与分支菌素生物合成途径中的关键酶，水杨酸-AMP 连接酶 (MbtA) 结合。Mycobactin-IN-1 是分支菌素生物合成的抑制剂，具有抗分枝杆菌的作用。
T33537	Mycobactin P
	Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors.
T25955	Picromycin Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin
	Picromycin is a 14-membered macrolide antibiotic and Prolyl endopeptidase (PREP) inhibitor. Pikromycin shows activity against gram-positive bacteria including mycobacteria.
T62840	Bromperidol hydrochloride
	Bromperidol hydrochloride (R-11333 hydrochloride) 具有抗精神病作用，能够较好的亲和中枢多巴胺受体 D2 (dopamine receptors D2)。Bromperidol hydrochloride 与 Spectinomycin 能够协同杀灭分枝杆菌 (mycobacteria)。
T16749	Rifalazil 利福拉齐,KRM-1648,ABI-1648	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis (MIC: 0.00025 to 0.0025 μg/ml).
T40520	Thiophene-2 Thiophene-2,TP2
	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
T73271	MMV688845 (R)-GSK1729177A
	MMV688845 是一种作用于非结核分枝杆菌的 RNA 聚合酶抑制剂，可有效杀灭脓肿分枝杆菌，并展现出对结核病的治疗潜力。
T75313	Methdilazine
	Methdilazine hydrochloride，一种口服活性抗生素（组胺拮抗剂），在体外和体内均能有效抑制多种分枝杆菌的活性。其最小抑菌浓度（MIC）值介于5-15 μg/mL之间，适用于传染病相关研究。
T63786	WX-081
	WX-081 是抗结核剂 (anti-tuberculosis)，对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果，并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml)，对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。
T83940	sCy5DL-amide
	sCy5DL-amide是一种荧光D-氨基酸，适用于标记多种细菌的肽聚糖，包括革兰氏阳性菌、革兰氏阴性菌和分枝杆菌。特别适合于革兰氏阳性的B.subtilis的标记。使用sCy5DL-amide标记的细菌可通过单分子定位显微镜技术(SMLM；也称为PALM或STORM)进行成像。激发/发射最大值为646/666 nm。
T83939	sCy5DA
	sCy5DA是一种荧光D-氨基酸，适用于标记活细菌中的肽聚糖。它能高效地整合进各种细菌的肽聚糖中，包括革兰氏阳性菌、革兰氏阴性菌和分枝杆菌，尤其在革兰氏阴性的C. crescentus中整合效果显著。使用sCy5DA标记的细菌可以通过单分子定位显微镜(SMLM；也称为PALM或STORM)进行成像。激发/发射峰值=646/665 nm。

化合物

Cat.No: T14830

Synonym: 溴哌利多,R-11333

Target: 5-HT Receptor

Cat.No: T0972

Synonym: INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide

Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy

Antimycobacterial agent-4

Cat.No: T60073

Synonym: 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide

Target: Antibacterial

Antimycobacterial agent-3

Cat.No: T63865

Antimycobacterial agent-1

Cat.No: T61853

Mycobacterial Zmp1-IN-1

Cat.No: T72306

Antimycobacterial agent-6

Cat.No: T79281

Antimycobacterial agent-2

Cat.No: T63420

Cat.No: T0377

Synonym: NSC-141046,氯法齐明,氯苯吩嗪

Target: DNA, Antibacterial, Antibiotic

Bedaquiline fumarate

Cat.No: T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323

Target: Antibacterial, Antibiotic

Deoxycytidine triphosphate trisodium salt

Cat.No: T7518

Synonym: 2'-脱氧胞苷-5'-三磷酸三钠盐,2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Antibiotic

Deoxypheganomycin D

Cat.No: T23979

Cat.No: T26189

Synonym: AM 2947,Antibiotic A 39183B,AM2947,AM-2947

Mycobactin-IN-1

Cat.No: T60486

Cat.No: T33537

Cat.No: T25955

Synonym: Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin

Bromperidol hydrochloride

Cat.No: T62840

Cat.No: T16749

Synonym: 利福拉齐,KRM-1648,ABI-1648

Target: DNA/RNA Synthesis

Cat.No: T40520

Synonym: Thiophene-2,TP2

Cat.No: T73271

Synonym: (R)-GSK1729177A

Cat.No: T75313

Cat.No: T63786

Cat.No: T83940

Cat.No: T83939

Cat. No.	Product Name	Target	Signaling Pathways
T0793	Kanamycin sulfate 硫酸卡那霉素,Kanamycin monosulfate,Kanamycin A monosulfate,Ophtalmokalixan	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Kanamycin sulfate (Kanamycin monosulfate) 是氨基糖苷类杀菌抗生素，它通过与细菌30S 核糖体结合起作用。
TN6057	1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.

天然产物

Kanamycin sulfate

Cat.No: T0793

Synonym: 硫酸卡那霉素,Kanamycin monosulfate,Kanamycin A monosulfate,Ophtalmokalixan

Target: ribosome, Antibacterial, Antibiotic

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone

Cat.No: TN6057

Synonym: (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one

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