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Cat. No. | Product Name | Target | Signaling Pathways |
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T19940 |
Sulfoxaflor
GF 2372,氟啶虫胺腈,GF 2032,XDE 208 |
AChR | Neuroscience |
Sulfoxaflor (GF 2032) 是 nAChR1 和 nAChR2 亚型的激动剂,是一种作用于昆虫中枢神经系统的内吸性杀虫剂。 Sulfoxaflor 用于防治吸食汁液的昆虫,如褐飞虱、烟粉虱、桃蚜和棉蚜。 | |||
TQ0291 |
Firategrast
SB 683699 |
Integrin | Cytoskeletal Signaling |
Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。 | |||
T15472 |
Hepsulfam
NCI 329680,ZINC01574758 |
Others | Others |
Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors). | |||
T71182 |
N 0745
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N 0745 inhibits 2-[125I]-iodomelatonin binding to median eminence/pars tuberalis membranes with an affinity similar to that of melatonin. | |||
T71774 |
Territrem B
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Territrem B is a mycotoxin that irreversibly inhibits acetylcholinesterase (AChE). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg. | |||
T80185 |
Huwentoxin I
HWTX-I |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Huwentoxin I (HWTX-I)为一种肽毒素,针对电压门控钠通道和N型钙通道具有抑制作用。该化合物对大鼠海马神经元和蟑螂DUM神经元的钠离子通道展现出抑制能力,其IC50值分别为66.1 nM和4.80 nM。 | |||
T69821 |
AMP423
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AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive. | |||
T74614 | PROTAC Hemagglutinin Degrader-1 | ||
PROTACHemagglutinin Degrader-1 (Compound V3) 是一种有效的 PROTAC 流感病毒血凝素 (influenza hemagglutinin(HA)) 降解剂,降解中值浓度为 1.44 μM。PROTACHemagglutinin Degrader-1 具有广谱抗流感病毒活性。 | |||
T28494 |
R-82913
NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib |
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R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold | |||
T79067 |
PROTAC BTK Degrader-3
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PROTACs | PROTAC |
PROTACBTK Degrader-3为BTKPROTAC降解剂,具有效力,其在Mino细胞中BTK降解的DC50值为10.9 nM。该降解剂具有应用于研究B细胞恶性肿瘤潜力,包括慢性淋巴细胞恶性肿瘤。 | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... | |||
T38193 |
β-Endorphin (1-27) (human) (trifluoroacetate salt)
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β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. Intracerebroventricular administration of β-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2S2169 |
Naringenin trimethyl ether
柚皮素三甲醚,5,7,4'-Trimethoxyflavanone |
Others | Others |
Naringenin trimethyl ether (5,7,4'-Trimethoxyflavanone) 是四季米仔兰枝、叶的成分。它具有明显的杀螺作用,对 P. canaliculata 作用的 LC50值为 3.9 μg/ mL。 | |||
TN1343 |
8-Geranyloxypsoralen
8-香叶草氧基补骨脂素 |
Anti-infection; P450; BACE | Metabolism; Microbiology/Virology; Neuroscience |
8-Geranyloxypsoralen 是一种呋喃香豆素,分离自葡萄柚,是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。 | |||
TN4084 |
Fumitremorgin B
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Antifection | Microbiology/Virology |
Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic |